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Valganciclovir combined tablets and preparation method thereof

A technology of valganciclovir hydrochloride and combination tablets, which is applied in the field of valganciclovir combination tablets and its preparation, can solve the problems of insufficient curative effect and high cost, and achieve reduction of infection, low price, and improvement of immunity The effect of the function

Inactive Publication Date: 2019-08-02
南京瑄宇医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the existing valganciclovir oral medicines only contain valganciclovir, a main active substance that exerts the curative effect against CMV virus, which can only inhibit the amplification of CMV virus, and the curative effect is insufficient; and the cost is relatively high. high

Method used

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  • Valganciclovir combined tablets and preparation method thereof
  • Valganciclovir combined tablets and preparation method thereof
  • Valganciclovir combined tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A valganciclovir combination tablet, comprising the following components in parts by mass:

[0053] Valganciclovir hydrochloride 10 parts;

[0054] Resveratrol 25 parts;

[0055] 8 parts propolis powder;

[0056] 30 parts of cornstarch;

[0057] Filling agent 20 parts;

[0058] Lubricant 0.3 parts.

[0059] Specifically, the filler is pregelatinized starch;

[0060] Described lubricant is magnesium stearate.

[0061] The preparation method of above-mentioned valganciclovir combination tablet, comprises the steps:

[0062] (1) After mixing valganciclovir hydrochloride and resveratrol, pulverize and pass through an 80-mesh sieve to obtain the main drug powder; other component materials are respectively pulverized and passed through a 60-mesh sieve, and are separately equipped for use;

[0063] (2) Add 1 / 4 of the total volume of each component in a clean container, then add the main drug powder obtained in step (1), propolis powder and cornstarch obtained in step (1...

Embodiment 2

[0066] A valganciclovir combination tablet, comprising the following components in parts by mass:

[0067] Valganciclovir hydrochloride 12 parts;

[0068] Resveratrol 20 parts;

[0069] 7 parts propolis powder;

[0070] 35 parts of cornstarch;

[0071] 22 parts of filler;

[0072] Lubricant 0.4 parts.

[0073] Specifically, the filler is a combination of microcrystalline cellulose and sodium alginate, and their mass ratio is 1:1.

[0074] Described lubricant is talcum powder.

[0075] The preparation method of above-mentioned valganciclovir combination tablet, comprises the steps:

[0076] (1) After mixing valganciclovir hydrochloride and resveratrol, pulverize and pass through an 80-mesh sieve to obtain the main drug powder; other component materials are respectively pulverized and passed through a 60-mesh sieve, and are separately equipped for use;

[0077] (2) Add deionized water of one-third of the total volume of each component in a clean container, then add the ma...

Embodiment 3

[0080] A valganciclovir combination tablet, comprising the following components in parts by mass:

[0081] Valganciclovir hydrochloride 15 parts;

[0082] Resveratrol 15 parts;

[0083] 5 parts propolis powder;

[0084] 40 parts of cornstarch;

[0085] Filling agent 25 parts;

[0086] Lubricant 0.5 part.

[0087] Specifically, the filler is a composition of pregelatinized starch, microcrystalline cellulose and sodium alginate, and their mass ratio is 2:1:1.

[0088] Described lubricant is magnesium stearate.

[0089] The preparation method of above-mentioned valganciclovir combination tablet, comprises the steps:

[0090] (1) After mixing valganciclovir hydrochloride and resveratrol, pulverize and pass through an 80-mesh sieve to obtain the main drug powder; other component materials are respectively pulverized and passed through a 60-mesh sieve, and are separately equipped for use;

[0091] (2) Add 1 / 4 of the total volume of each component in a clean container, then ad...

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Abstract

The invention discloses valganciclovir combined tablets and a preparation method thereof, and belongs to the technical field of pharmacy. The valganciclovir combined tablets comprise the following components in parts by mass: 10-15 parts of valganciclovir hydrochloride, 15-25 parts of resveratrol, 5-8 parts of propolis powder, 30-40 parts of corn starch, 20-25 parts of filler and 0.3-0.5 part of alubricant. The preparation method of the valganciclovir combined tablets comprises the steps of firstly, mixing, crushing and sieving the valganciclovir hydrochloride and the resveratrol to prepare main medicine powder, and crushing and sieving the other components respectively for use; adding the main medicine powder, the propolis powder, the corn starch and the filler into deionized water in sequence to prepare a soft material, then conducting extrusion granulation, drying and granule straightening, and conducting mixing and tabletting on granules and the lubricant to prepare the valganciclovir combined tablets. The anti-CMV efficacy of the combined tablets is improved, and the pharmacy cost is low; and the uniform degree of specifications of the medicines prepared according to the preparation method is high, and the preparation efficiency is high.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a valganciclovir combination tablet and a preparation method thereof. Background technique [0002] Cytomegalovirus (CMV) belongs to the herpes virus family. The virus is in a resting state in individuals with normal immune function, but when the immune function is impaired (such as AIDS patients, organ transplantation and bone marrow transplantation, receiving immunosuppressive patients, etc.), the virus can cause serious illness. CMV infection occurs through direct contact with infected tissue or bodily fluids (such as saliva, blood, or urine). The routes of transmission are very extensive, and the most common ones are intrauterine, cervical secretion or breast milk transmission, close contact with young children in the intensive care unit, and sexual contact. The most common condition of CMV in AIDS patients is CMV retinitis, an eye infection that can lead to blindness. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/10A61K31/522A61K31/05A61K35/644A61K47/36
CPCA61J3/10A61K31/05A61K31/522A61K35/644A61K47/36
Inventor 方纯汪善和
Owner 南京瑄宇医药科技有限公司
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