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Double-component self-adhering gastric mucosa protective glue for gastroscope to be sprayed to surface of injured gastric mucosa and application thereof

A gastroscope and gastric mucosal technology, applied in the field of two-component self-adhesive gastric mucosal protective glue, can solve problems such as easy to fall off, cannot fully exert the protective effect of gastric mucosa, and achieve the effect of promoting regeneration and repair

Active Publication Date: 2019-08-02
HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent only uses purely physical principles to protect the gastric mucosa. The cross-linking agent used is acid-soluble calcium, which is insoluble in neutral solutions and is in a granular state. It is suitable for oral use and is not suitable for injection through syringes. This product cannot adhere well to the wound surface of the gastric mucosa, it is very easy to fall off, and cannot fully exert the protective effect of the gastric mucosa

Method used

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  • Double-component self-adhering gastric mucosa protective glue for gastroscope to be sprayed to surface of injured gastric mucosa and application thereof
  • Double-component self-adhering gastric mucosa protective glue for gastroscope to be sprayed to surface of injured gastric mucosa and application thereof
  • Double-component self-adhering gastric mucosa protective glue for gastroscope to be sprayed to surface of injured gastric mucosa and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A two-component self-adhesive gastric mucosa protective glue suitable for spraying on the surface of gastric injury mucosa by gastroscope, the composition is as follows, and the raw materials are all commercially available products.

[0025] Adhesive Layer Components:

[0026] Mussel mucin 25g,

[0027] Sodium chloride 0.9g,

[0028] The above ingredients are dissolved in 100ml of distilled water, adjusted to pH=5.0 with acetic acid, packaged in 2.0ml bottles, and sterilized by irradiation.

[0029] Protective layer components:

[0030] Sodium Alginate 7.5g,

[0031] Calcium chloride 0.5g,

[0032] Sodium citrate 2.5g,

[0033] Dissolve the above ingredients in distilled water, adjust the pH to 8.5 with sodium hydroxide, and prepare a solution with a mass concentration of 3.0%, then add 1g of glycerin per 100ml of the solution, pack in 5ml per bottle, and sterilize by high-temperature steam.

Embodiment 2

[0035] A two-component self-adhesive gastric mucosa protective glue suitable for spraying gastroscope on the surface of gastric injury mucosa, its composition is as follows, and the raw materials are all commercially available products:

[0036] Adhesive layer components

[0037] Mussel Mucin 5g,

[0038] Sodium chloride 0.9g,

[0039] The above ingredients are dissolved in 100ml of distilled water, adjusted to pH=5.0 with citric acid, packaged in 2.0ml bottles, and sterilized by irradiation.

[0040] Protective layer components

[0041]

[0042] Dissolve the above ingredients in distilled water, adjust the pH to 8.5 with sodium hydroxide, configure it to a mass concentration of 2.5%, add 5g of polyvinyl alcohol per 100ml, pack in 5ml bottles, and store in high-temperature steam sterilization.

Embodiment 3

[0044] A two-component self-adhesive gastric mucosa protective glue suitable for spraying gastroscope on the surface of gastric injury mucosa, its composition is as follows, and the raw materials are all commercially available products:

[0045] Adhesive layer components

[0046] Mussel mucin 10g,

[0047] Sodium chloride 0.9g,

[0048] The above ingredients are dissolved in 100ml of distilled water, adjusted to pH=5.0 with acetic acid, packaged in 2.0ml bottles, and sterilized by irradiation.

[0049] Protective layer components

[0050] Sodium alginate 10g,

[0051] Calcium Gluconate 3g,

[0052] Sodium citrate: 2.5g,

[0053] Sodium hydroxide (pH regulator): adjust the pH to 8.0,

[0054] During the preparation process, keep the pH as weakly alkaline. The above ingredients are dissolved in distilled water, configured so that the mass concentration is 3.5%, and 0.15 g of mannitol and 0.15 g of sorbitol are added per 100 ml, packaged in 5 ml per bottle, and stored in h...

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Abstract

The invention belongs to the technical field of biomedicine, and particularly relates to a double-component self-adhering gastric mucosa protective glue for gastroscope to be sprayed to surface of injured gastric mucosa and application thereof. The double-component self-adhering gastric mucosa protective glue consists of an adhering layer component and a protective layer component, wherein the adhering layer component is a water solution containing mussel adhesive protein, and the protective layer component is a water solution containing gluing substance, water-soluble calcium and calcium complexing agent. The double-component self-adhering gastric mucosa protective glue has the advantage that by utilizing the self-adhering characteristic of the adhering layer containing the mussel adhesive protein, the injured gastric mucosa and the gastric mucosa protective glue are tightly connected together.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a two-component self-adhesive gastric mucosa protective glue suitable for spraying a gastroscope on the surface of gastric damaged mucosa and its application. Background technique [0002] Endoscopic gastric mucosal resection and gastric mucosal dissection are minimally invasive surgeries for the resection of early gastric cancer and benign gastric tumors. They can not only achieve the goal of radically curing early gastric cancer, but also have the advantages of less trauma and less impact on the quality of life of patients. Gradually replace some traditional surgery. However, at present, the postoperative wound is only treated with hemostasis, and there is no good wound protection measure. Under the action of gastric acid and pepsin, exposed wounds go through the stages of ulcer activity, healing and scarring, and the healing time of wounds is also longer. Clinical resear...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/08A61L24/00A61K38/17A61K9/00A61K47/36A61P1/04
CPCA61L24/108A61L24/08A61L24/0015A61K38/1767A61P1/04A61K9/0065A61K47/36A61L2300/252A61L2300/412
Inventor 戴建英
Owner HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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