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A surface acoustic wave droplet excitation device and a method for fixed-point release of tumor single cells

A surface acoustic wave and tumor cell technology, applied in the field of micro-total analysis system, achieves the effect of wide application, controllable size and high integration

Active Publication Date: 2021-07-16
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are no related reports on the combination of surface acoustic wave droplet excitation and three-dimensional nano-substrates to capture and release tumor cells at a fixed point to solve the problem of tumor heterogeneity in clinical research

Method used

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  • A surface acoustic wave droplet excitation device and a method for fixed-point release of tumor single cells
  • A surface acoustic wave droplet excitation device and a method for fixed-point release of tumor single cells
  • A surface acoustic wave droplet excitation device and a method for fixed-point release of tumor single cells

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Embodiment 1

[0050] A surface acoustic wave liquid drop excitation device includes a surface acoustic wave liquid drop excitation chip, an XYZ three-dimensional mobile platform 8, a particle capture base plate 4, a signal generator and a power amplifier. Its overall structure is as figure 1 shown.

[0051] figure 2 The structure of the surface acoustic wave droplet excitation chip is shown, which is composed of a piezoelectric material substrate 5 , arc-shaped interdigitated electrodes 6 and an annular water tank 7 . The piezoelectric material substrate 5 is a 128°Y-X lithium niobate single crystal. The arc-shaped interdigitated electrodes 6 are obtained by soft lithography on the piezoelectric material, the electrode arc angle is 40°, and the wavelength is 100 μm. The annular water tank 7 is an annular groove, which is made by soft photolithography on the piezoelectric material substrate 5, and the photoresist is SU8 2100; the height of the water tank is 200 μm, and the diameter is 2 ...

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Abstract

The invention provides a surface acoustic wave droplet excitation device and a method for fixed-point release of tumor single cells. The device includes a surface acoustic wave droplet excitation chip, an XYZ three-dimensional mobile platform, a particle capture substrate, a signal generator and a power amplifier; the surface acoustic wave droplet excitation chip is driven by a signal generator and a power amplifier, and fixed on the XYZ three-dimensional On the mobile platform; the particle capture substrate plate is placed under the surface acoustic wave droplet excitation chip. The device can be used for targeted release of tumor single cells and other rare cells or biological particles. The present invention has the following advantages: convenient operation, high single-cell release efficiency, and miniaturization of the acoustic chip; in addition, it has wide applicability and can be used in other material systems for capturing and releasing rare cells to achieve fixed-point release of rare cells. It has considerable application potential in the field of research.

Description

technical field [0001] The invention belongs to the field of micro-total analysis systems, and in particular relates to a method for exciting surface acoustic wave droplets and releasing tumor single cells at fixed points. Background technique [0002] Circulating tumor cells refer to the cells that fall off the primary tumor lesion and enter the peripheral blood circulation system. They play an important role in cancer metastasis and recurrence. They can be used as clinical detection markers to measure the development status of cancer and the prognosis of cancer patients after treatment. Effect. In recent years, circulating tumor cell detection technology is becoming a fast, reliable, non-invasive, reproducible and low-cost new cancer diagnosis technology, which is called real-time tumor liquid biopsy technology. As this field of research continues to grow, further downstream analysis of captured circulating tumor cells, including quantitative PCR, FISH, and whole-genome a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M1/00C12M1/42C03C17/28C12N5/09C12N13/00
CPCC03C17/28C03C2218/111C12M25/06C12M35/04C12N5/0693C12N13/00
Inventor 国世上陈柯坷魏小云
Owner WUHAN UNIV
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