Platinum-based compound based on nucleolar stress

A technology of nucleolus stress and compounds, applied in platinum anti-tumor compounds to overcome clinical platinum drug resistance and achieve excellent anti-tumor activity
CN110128477AInactive Publication Date: 2019-08-16TIANJIN MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN MEDICAL UNIV
Publication Date
2019-08-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a platinum-based compound based on nucleolar stress, wherein the platinum-based compound is a platinum-based antitumor compound formed by carrying out a nitrile-secondary amineClick reaction on cis-monochloro mononitrile diamino platinum and a primary amine-containing RNA polymerase I inhibitor. According to the present invention, the platinum-based antitumor compound hasgood RNA polymerase I inhibitory activity and good tumor selectivity, such that the platinum-based compound has antitumor activity suprior to classical platinum-based drugs, and can reduce toxic-sideeffects and overcome the drug resistance of clinical platinum-based drugs.
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Description

technical field

[0001] The invention belongs to the technical field of platinum compounds, and more specifically relates to a class of platinum anti-tumor compounds based on nucleolus stress and the research on anti-tumor effect, reduction of toxic and side effects and overcoming clinical platinum drug resistance. Background technique

[0002] Cancer is a major killer that threatens human beings all the time in today's world, and the research on cancer treatment has very far-reaching practical significance. Platinum antineoplastic drugs are an important class of metal chemotherapeutic drugs, which are used in more than half of chemotherapy methods. The representative drug, cisplatin, has a broad anti-tumor spectrum and strong effect, and has synergistic effects with many anti-tumor drugs without cross-resistance. It has remarkable curative effect on ovarian cancer and testicular cancer. cure rate. However, severe adverse reactions (such as myelosuppression, leukopenia, oto...

Claims

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