Bone defect repairing device and preparing method thereof and slow release drug composition

Abstract

The invention provides a bone defect repairing device and a preparing method thereof and a slow release drug composition. The bone defect repairing device comprises multiple support layers and multiple drug slow releasing layers, and the support layers and the drug slow releasing layers are alternatively distributed from top to bottom; each support layer comprises multiple parallel support convexridges, each drug slow releasing layer comprises multiple parallel drug slow releasing convex ridges, and the support convex ridges and the drug slow releasing convex ridges in the adjacent support layers and drug slow releasing layers cross. The bone defect repairing device comprises the support layers and the drug slow releasing layers, and the support layers and the drug slow releasing layers are alternatively distributed from top to bottom; the bone defect repairing device is prepared through a 3D printing technology, the appearance is completely matched with a bone defect region, and thebone defect repairing device has a hole diameter facilitating bone ingrowth and good connectivity; preferably, the materials of the drug slow releasing layers include zoledronic acid and tricalcium phosphate, and thus the bone defect repairing device has good drug slow releasing performance, and can regulate the functions of osteoblasts and osteoclasts bidirectionally and promote repairing of osteoporotic bone defects.

Description

technical field [0001] The invention belongs to the technical field of bone repair, and in particular relates to a bone defect repair device, a preparation method thereof and a slow-release pharmaceutical composition. Background technique [0002] Osteoporosis is a systemic skeletal disease characterized by reduced bone mass and destruction of bone microarchitecture. The most serious hazard of osteoporosis is concurrent osteoporotic fracture. Osteoporotic fractures are mostly comminuted fractures, and there are often bone defects after fracture reduction. After fixation, the stability of the fracture area is poor, and fracture displacement, internal fixation loosening, and fixation plate pullout are prone to occur, resulting in complete failure of internal fixation. Ultimately lead to delayed union or nonunion of fractures, seriously affecting the quality of life of patients and increasing mortality. At present, the "gold standard" for clinical bone defect repair is autolo...

AI Technical Summary

Problems solved by technology

Natural polymer materials such as chitosan, hyaluronic acid, collagen, etc., have high biological activity, are conducive to cell growth and adhesion, and promote the repair of bone defect areas, but their mechanical strength is insufficient, unable to bear or only partially bear weight, and prone to defect areas Collapse, affecting the repair of osteoporotic bone defect areas, severely limiting its application range

Synthetic polymer materials (tricalcium phosphate, polylactic acid, polyglycolic acid, polylactic acid polyglycolic acid, etc.) have high mechanical strength and are easy to produce, but have low biological activity

More importantly, none of the above materials can specifically regulate osteogenesis and osteoclasts in the osteoporotic bone defect area, and promote the repair of the defect area.

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