Anti-alpha-synuclein monoclonal antibody and application thereof

A technology of synuclein and monoclonal antibody, applied in application, antibody, anti-animal/human immunoglobulin, etc., can solve the problem of undetermined efficacy of antibody
CN110172098AActive Publication Date: 2019-08-27CHANGCHUN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHANGCHUN UNIV OF TECH
Publication Date
2019-08-27

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Abstract

The invention relates to the technical field of antibody drugs, and specifically relates to an anti-alpha-synuclein monoclonal antibody and application thereof. The anti-alpha-synuclein monoclonal antibody provided by the invention can specifically bind to monomers and aggregates of alpha-synuclein, has high affinity to monomers and aggregates of a human alpha-synuclein, has no affinity to beta-synuclein and gamma-synuclein, can effectively inhibit the polymerization of the monomers of alpha-synuclein, promote microglial cells to clear formed alpha-synuclein aggregates, and protect neuronal cells from the toxicity of the alpha-synuclein aggregates, and can be used to prevent, treat and diagnose alpha-synuclein-related diseases and conditions such as Parkinson's disease, Lewy body dementia,Alzheimer's disease with Parkinson's disease, pure autonomic failure, and multiple system atrophy.
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Description

technical field

[0001] The invention relates to the technical field of antibody medicines, in particular to monoclonal antibodies against α-synuclein and applications thereof. Background technique

[0002] 1. α-synuclein (α-synuclein)

[0003] α-synuclein (α-synuclein) is a member of the synuclein family, which consists of a group of proteins with a molecular weight of about 14KD, including β-synuclein and γ-synuclein in addition to α-synuclein. Human α-synuclein is encoded by the SNCA gene located on the fourth chromosome. It contains 140 amino acids and is divided into three structural domains, which are the N-terminal KTKEGV repeat region (1-60aa), the middle NAC region (61-95aa) and the C Proline-rich region (96-140aa) at the end. α-synuclein is widely expressed in brain tissue, accounting for about 1% of the total cytoplasmic protein in brain cells, especially highly expressed in neocortex, hippocampus, substantia nigra, thalamus and cerebellum, and also expressed in ...

Claims

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