Multi-functional liposome having oxidation-reduction responsiveness and capable of reinforcing tissue permeation

A liposome and responsive technology, which is applied in the field of multifunctional liposome and its preparation, can solve problems such as difficult to achieve therapeutic effect, and achieve the effect of enhancing synergistic anti-tumor effect, increasing oxygen concentration, and enhancing tissue penetration
CN110179754AInactive Publication Date: 2019-08-30FUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FUZHOU UNIV
Publication Date
2019-08-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a multi-functional liposome having oxidation-reduction responsiveness and capable of reinforcing tissue permeation, and a preparation method and application of the multi-functional liposome. A disulfide bond mediated oxidation-reduction responsiveness DSPE-S-S-chemotherapeutic drug prodrug is modified on the surface of the liposome, a hydrophobic photosensitizer is loaded on a phospholipid bimolecular layer, and a hydrophilic drug capable of reinforcing tissue permeability is entrapped in a water phase in the liposome. The liposome prepared by the preparation method disclosed by the invention can release chemotherapeutic drugs in a manner of oxidation-reduction responsiveness, permeation of the liposome in tumor tissue and infiltration of the liposome in peripheraloxygen are reinforced, the liposome can be used as a pharmaceutical preparation capable of resisting breast cancer, resisting liver cancer, resisting lung cancer or resisting cervical cancer for treating tumors, and the effect of synergistically resisting the tumor with chemotherapy / photodynamic therapy is increased.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a multifunctional liposome which has redox responsiveness and can enhance tissue penetration, a preparation method and application thereof. Background technique

[0002] It is usually difficult to achieve a satisfactory therapeutic effect with a single mode of tumor therapy, and multimodal combination therapy can use different mechanisms of action to achieve synergistic anti-tumor effects and improve efficacy. Photodynamic therapy (PDT) is an emerging non-invasive tumor treatment method. Its principle is to use photosensitizers to convert surrounding oxygen molecules into cytotoxic singlet oxygen ( 1 o 2 ), so as to achieve the purpose of killing tumor cells. Chemotherapy is one of the main methods for the treatment of malignant tumors. Combining PDT with chemotherapy can significantly enhance the antitumor effect. At the same time, drugs that enhance ...

Claims

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