Colloidal pectin bismuth capsule and preparation process thereof
A preparation technology of colloidal bismuth pectin, applied in the direction of capsule delivery, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc. Good, not conducive to labor protection and other issues, to achieve the effect of easy product quality control, easy swallowing, rapid disintegration and uniform dispersion
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[0032] Example 1
[0033]
[0034] Preparation Process:
[0035] (1) Airflow pulverized colloidal bismuth pectin and croscarmellose sodium, mix them evenly according to the prescription, and set aside;
[0036] (2) Add low-substituted hydroxypropyl cellulose LH-31 into a centrifugal granulator, and slowly spray purified water into a blank pellet core;
[0037] (3) Sprinkle the mixed powder prepared in (1) into the blank pellet core prepared in (2) at a fixed rate, while slowly spraying in purified water. After the powder is added, stop spraying the purified water and continue spheronizing for 10 minutes ;
[0038] (4) Put the pellets prepared in (3) in a fluidized bed to dry, and fill the capsules to obtain it.
Example Embodiment
[0039] Example 2
[0040]
[0041] Preparation Process:
[0042] (1) Airflow pulverized colloidal bismuth pectin and croscarmellose sodium, mix them evenly according to the prescription, and set aside;
[0043] (2) Add low-substituted hydroxypropyl cellulose LH-31 into a centrifugal granulator, and slowly spray purified water into a blank pellet core;
[0044] (3) Sprinkle the mixed powder prepared in (1) into the blank pellet core prepared in (2) at a fixed rate, while slowly spraying in purified water. After the powder is added, stop spraying the purified water and continue spheronizing for 20 minutes ;
[0045] (4) Put the pellets prepared in (3) in a fluidized bed to dry, and fill the capsules to obtain it.
Example Embodiment
[0046] Example 3
[0047]
[0048] Preparation Process:
[0049] (1) Airflow pulverized colloidal bismuth pectin and croscarmellose sodium, mix them evenly according to the prescription, and set aside;
[0050] (2) Add low-substituted hydroxypropyl cellulose LH-31 into a centrifugal granulator, and slowly spray purified water into a blank pellet core;
[0051] (3) Sprinkle the mixed powder prepared in (1) into the blank pellet core prepared in (2) at a fixed rate while slowly spraying purified water into it. After the powder mixture is added, stop spraying the purified water and continue spheronizing for 30 minutes ;
[0052] (4) Put the pellets prepared in (3) in a fluidized bed to dry, and fill the capsules to obtain it.
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