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Composition containing cannabidiol for treating nerve tinnitus and preparation method of composition

The technology of cannabidiol and composition is applied in the field of composition containing cannabidiol and its preparation, which can solve the problems of large side effects and poor curative effect, and achieves repair of auditory nerve, regulation of blood supply, promotion of aerobic metabolism and energy effect of supply

Inactive Publication Date: 2019-09-06
李卫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems of poor curative effect and large side effects of existing drugs for treating nervous tinnitus, the present invention provides a composition containing cannabidiol for treating nervous tinnitus and a preparation method thereof

Method used

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  • Composition containing cannabidiol for treating nerve tinnitus and preparation method of composition

Examples

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Effect test

Embodiment 1

[0035] This example provides a composition containing cannabidiol for treating nervous tinnitus, including the following components by mass: 1 to 5 parts of cannabidiol, 1 to 3 parts of puerarin, and 1 to 3 parts of total tanshinone 1-2 parts, 1-2 parts of trichozine phosphate, 20-80 parts of lecithin, 30-100 parts of soybean oil, 20-60 parts of Tween 8020, 1-10 parts of polylysine, 100-800 parts of glycerin and deionized water 1 to 200 copies.

[0036] In this example, cannabidiol has antioxidant effect and is a natural neuroprotective agent, which can reduce oxidative stress, prevent auditory nerve degeneration, and reduce the risk of ischemic injury; puerarin expands inner ear blood vessels, regulates blood flow, Promote cell metabolism, improve inner ear blood circulation, thereby helping to restore the function of inner ear cells; total tanshinone can improve microcirculation blood flow velocity, increase cochlear blood flow, dilate blood vessels, reduce blood viscosity, ...

Embodiment 2

[0038] This embodiment provides a composition containing cannabidiol for the treatment of nervous tinnitus, including the following components by mass: 3 parts of cannabidiol, 2 parts of puerarin, 2 parts of total tanshinone, and phosphonate 1 part, 55 parts of lecithin, 70 parts of soybean oil, 8060 parts of Tween, 7 parts of polylysine, 700 parts of glycerin and 100 parts of deionized water.

[0039] The mass concentration of cannabidiol in the composition obtained in this embodiment is 0.3%, the mass concentration of puerarin is 0.2%, the mass concentration of total tanshinone is 0.2%, and the mass concentration of ligustrazine phosphate is 0.1%.

Embodiment 3

[0041] This example provides a composition containing cannabidiol for the treatment of nervous tinnitus, including the following components by mass: 5 parts of cannabidiol, 3 parts of puerarin, 3 parts of total tanshinone, and phosphonate 2 parts, 20 parts of lecithin, 30 parts of soybean oil, 8020 parts of Tween, 1 part of polylysine, 100 parts of glycerin and 16 parts of deionized water.

[0042] The mass concentration of cannabidiol in the composition obtained in this example is 2.5%, the mass concentration of puerarin is 1.5%, the mass concentration of total tanshinone is 1.5%, and the mass concentration of ligustrazine phosphate is 1.0%.

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Abstract

The invention relates to a composition containing cannabidiol for treating nerve tinnitus and a preparation method of the composition, and belongs to the technical field of pharmaceutical compositions. The invention aims to solve the problems of poor curative effect and large side effect of an existing medicine for treating neurogenic tinnitus. The invention provides the composition containing thecannabidiol for treating the nerve tinnitus. Effective medicinal components including the cannabidiol, puerarin, total tanshinone and ligustrazine phosphate are organically combined, an effect of recovering normal functions of auditory nerves of inner ears is achieved, a phospholipid complex is formed by the composition and lecithin, an oil phase component is formed by the phospholipid complex, soybean oil and Tween 80, an oil-in-water stable emulsion is formed by the oil phase component, glycerol and water under high shear and homogenization effect, and the average particle size of liquid drops reaches nanoscale. When the composition is used as the ear drops, transdermal absorption can be quickly realized, the composition enters ear capillaries and directly acts on the focus, and the composition can be used for treating neurogenic tinnitus and has treatment effects of low dosage, high drug effect, quick response and no toxic or side effect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical compositions, and in particular relates to a composition containing cannabidiol for treating nervous tinnitus and a preparation method thereof. Background technique [0002] Nervous tinnitus refers to the abnormal sound sensation produced under the condition of no external sound source, mostly high-frequency cicadas or harsh and sharp sounds. Nervous tinnitus is divided into sensory tinnitus, peripheral nervous tinnitus and central nervous tinnitus. Sensory tinnitus originates from the cochlea, and cochlear blood microcirculation disorder causes hair cell damage on the cochlear basement membrane due to ischemia and hypoxia; peripheral nervous tinnitus originates from auditory nerve cell damage; central nervous tinnitus originates from auditory nerve center damage or paralysis. [0003] Modern people's long-term stress, mental stress and fatigue, anger, getting angry and cold, otitis media...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K36/60A61K47/44A61K47/24A61P27/16C07C39/23C07C37/68A61K31/05A61K31/352A61K31/4965
CPCA61K31/05A61K31/352A61K31/4965A61K36/537A61K36/60A61K47/24A61K47/44A61P27/16C07C37/004A61K2300/00C07C39/23
Inventor 孟庆刚秦博宇李宝林李卫
Owner 李卫
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