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Novel bacillus preparation for veterinary use and preparation method of novel bacillus preparation

A new technology of Bacillus, which is applied in the field of veterinary drugs, can solve problems such as excreted with feces, non-reproduction of spores, and discounted use effects, and achieve the effects of shortening recovery time, ensuring recovery rate, and low production cost

Pending Publication Date: 2019-09-27
李会芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The spores do not reproduce and do not metabolize. They can only play a role after they are taken orally into the intestinal tract and transformed into propagules under the incubation of the intestinal liquid environment. However, it usually takes more than 4 hours for the spores to completely transform into propagules. For animals Generally speaking, it takes 4 to 6 hours for the feed to enter the mouth and form feces to be excreted. In this way, when the spores used orally are transformed into propagules, they have basically passed through the small intestine and reached the colon or rectum, and some have even passed through the colon or rectum. Excreted with the feces, the propagule cannot play an important role in the intestinal tract, resulting in a greatly reduced use effect

Method used

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  • Novel bacillus preparation for veterinary use and preparation method of novel bacillus preparation
  • Novel bacillus preparation for veterinary use and preparation method of novel bacillus preparation

Examples

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Embodiment 1-10

[0031] In order to make the description concise, the weight composition of a new veterinary Bacillus preparation described in Examples 1-10 is given in the form of a table below, as shown in Table 1 for details.

[0032] The weight composition of table 1 embodiment 1-10 (total 100g)

[0033]

[0034]

[0035] A kind of preparation method of the novel preparation of veterinary bacillus described in embodiment 1, comprises the following steps:

[0036] (a) At room temperature, add 0.5g of aluminum stearate to 15.0g of glyceryl diacetate, heat the system, and stir while heating. When the temperature reaches 95°C, keep it for 30 minutes, and the system will change from turbid to clear. After cooling to 50°C, the system returned to turbidity, and System 1 was obtained;

[0037] (b) Add 7.5g of polyethylene glycol 800, 17.5g of polyethylene glycol 1000 and 3.0g of polyethylene glycol 1500 into system 1, stir while adding, and maintain the temperature at 50°C to obtain system ...

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Abstract

The invention discloses a novel bacillus preparation for veterinary use. Every 100 g of the drug contains, 5.0-10.0 g of polyethylene glycol 800, 10.0-25.0 g of polyethylene glycol 1000, 1.0-5.0 g of polyethylene glycol 1500, 10.0-20.0 g of glycerol diacetate, 0.01-1.0 g of aluminum stearate, 0.01-3.0 g of bacillus powder, 0.7-1.0 g of sodium chloride, 0.1-4.0 g of anhydrous dextrose and the balance of deionized water. The prepared bacillus preparation is a solid at the normal temperature, is favorable for long-time storage of probiotics, can be converted into a liquid through slight heating during use and is favorable for recovery of bacillus. During drinking use, probiotics can be suspended in water for a long time and cannot sink into the bottom of water, uniform oral medication is guaranteed, waterlines cannot be blocked, and the preparation is convenient to use and remarkable in curative effect. Meanwhile, the invention also discloses a preparation of the novel preparation. The preparation method is high in operability and is favorable for production conversion.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to a novel preparation of veterinary bacillus and a preparation method thereof. Background technique [0002] As a commonly used probiotic preparation, Bacillus is widely used in the fields of medicine and aquaculture. Bacillus species commonly used in animal feeding include Bacillus subtilis, Bacillus licheniformis, etc. After oral administration, it can balance the intestinal microecological flora, promote feed digestion, stimulate mucosal immunity and improve production performance. After the feed added with Bacillus was eaten by animals, the incidence of enteritis was significantly reduced, the diarrhea was improved, and the feces were formed. After the sows eat, the milk secretion increases, the constipation situation is improved, the feces are not smelly, the air quality in the pig house is improved, and the respiratory diseases are reduced. After th...

Claims

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Application Information

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IPC IPC(8): A61K35/742A61K9/06A61K47/10A61K47/12A61K47/14A61K47/26A61K47/02A61P1/00A61P1/14
CPCA61K35/742A61K9/06A61K47/10A61K47/12A61K47/14A61K47/26A61K47/02A61P1/00A61P1/14
Inventor 金福源孙何云段凤娟曹伟伟温书香刘丹郭良夏爽刘苗苗李会芳
Owner 李会芳
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