Nuclear-shell nanogold composite material and preparation method and application

A composite material and nano-gold technology, which is applied in the field of core-shell nano-gold composite materials and preparation, can solve problems such as poor stability and poor biocompatibility, and achieve the effects of large loading capacity, simple preparation method, and wide application range

Active Publication Date: 2019-09-27
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the deficiencies in the prior art, the invention discloses a core-shell nano-gold composite material and its preparation method and application. The material improves the photothermal performance of gold nanorods and solves the problem of poor biocompatibility , poor stability, and the gold nanorod carrier has fluorescence characteristics, which has good application potential in photothermal therapy and bioimaging

Method used

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  • Nuclear-shell nanogold composite material and preparation method and application
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preparation example Construction

[0046] A preparation method of a core-shell type nano-gold composite material, comprising the steps of:

[0047] 1) Preparation of gold nanorod solution (AuNRs) by seed-free method:

[0048]Dissolve CTAB in ultrapure water, add chloroauric acid solution, silver nitrate solution, ascorbic acid solution, and sodium borohydride solution in sequence, then stir for 10-30s in a water bath at 30-40 degrees, and let it stand for 4-8 hours. Centrifuge at a speed of more than 10,000 rpm, remove the supernatant to obtain the lower colloidal solution, wash with deionized water, remove excess CTAB solution, and remove the lower colloidal solution to obtain the gold nanorod solution;

[0049] The molar ratio of each reaction component is CTAB: chloroauric acid: silver nitrate: ascorbic acid: sodium borohydride=80000:40-50:100-150:500-600:1-2.

[0050] Preferably, the molar ratio of each reaction component is CTAB: chloroauric acid: silver nitrate: ascorbic acid: sodium borohydride = 80000:...

Embodiment 1

[0076] 1) Preparation of gold nanorod solution (AuNRs) by seed-free method:

[0077] Synthesize gold nanorods by seedless method, first weigh 1.8218g CTAB powder and dissolve it in 50ml ultrapure water, and dissolve it by ultrasonic;

[0078] Take the dissolved CTAB 10ml 0.1M and put it into the Erlenmeyer flask, add 208ul 0.024M chloroauric acid solution, 100ul 0.01M silver nitrate solution, 60ul 0.1M ascorbic acid solution successively under stirring in a 37 degree water bath. Then add 16ul 1mM sodium borohydride solution and stir for 25s. After the solution was allowed to stand for 6 hours, it was centrifuged with ultrapure water to remove excess CTAB to obtain a gold nanorod solution.

[0079] The sodium borohydride solution is prepared from ice water.

[0080] 2) Preparation of gold nanorods wrapped in mesoporous silica,

[0081] After sonicating the prepared gold nanorods for 15 minutes, take 10ml and add it to the Erlenmeyer flask, stir in a 30-degree water bath and ...

Embodiment 2

[0101] 1) Preparation of gold nanorod solution

[0102] Utilize the seedless method to synthesize gold nanorods, first weigh 1.8218g CTAB powder and dissolve it in 50ml ultrapure water, and dissolve it by ultrasonic; take the dissolved CTAB 10ml 0.1M and add it to the Erlenmeyer flask, and add 208 μl of it successively under stirring in a 37-degree water bath. .024M chloroauric acid solution, 100ul 0.01M silver nitrate solution, 60ul 0.1M ascorbic acid solution. Then add 16ul 1mM sodium borohydride solution (prepared with ice water), and stir for 25s. After the solution was allowed to stand for 6 hours, it was centrifuged with ultrapure water to remove excess CTAB to obtain a gold nanorod solution.

[0103] 2) Preparation of gold nanorods wrapped in mesoporous silica, after ultrasonication of the prepared gold nanorods for 15 minutes, take 10ml into the conical flask, stir in a 30-degree water bath, add 100ul 0.1M NaOH to react for 30min, and then add in three times 40ul TEO...

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Abstract

The invention provides a nuclear-shell nanogold composite material and a preparation method and application. The preparation method comprises the following steps: CTAB, a chloroauric acid solution, a silver nitrate solution, an ascorbic acid solution and a sodium borohydride solution are mixed to obtain a gold nanorod solution; a TEOS methanol solution is dripped after ultrasonic processing of the gold nanorod solution for the reaction to prepare a mesoporous silicon dioxide gold nanorod solution; an APTES methanol solution is added for an amination reaction to obtain an aminated mesoporous silicon dioxide gold nanorod solution; and a gold nanocluster solution is fed in the aminated mesoporous silicon dioxide gold nanorod solution for a reaction to obtain the nuclear-shell nanogold composite material. The material improves the photothermal performance of gold nanorods, enables gold nanorod carriers to achieve fluorescence characteristics, and achieves excellent application potential on photothermal therapy and biological imaging. The preparation method solves the problems of weak biocompatibility and weak stability of the gold nanorods.

Description

technical field [0001] The invention discloses a core-shell nano-gold composite material, a preparation method and an application thereof, and belongs to the technical field of nanometer materials and special materials. Background technique [0002] Gold nanorods have attracted extensive attention due to their unique physicochemical properties and their potential biophotonics applications, such as photothermal therapy, biosensing, molecular imaging, etc. Like spherical gold nanoparticles, gold nanorods themselves have specific surface plasmon resonance properties. By controlling their aspect ratio, longitudinal surface plasmon resonance properties from the visible to the near-infrared range can be obtained. In addition, the LP of gold nanorods is tunable in the near-infrared region. When irradiated by a near-infrared light source, the gold nanorods will quickly become a highly concentrated local heat source due to the plasmon resonance characteristics, and the heat generat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B82Y40/00B82Y30/00B22F1/02B22F1/00A61K49/00A61K47/02A61K41/00A61P35/00
CPCB22F9/24B82Y40/00B82Y30/00A61K49/0019A61K47/02A61K41/0052A61P35/00B22F1/145B22F1/16
Inventor 段倩倩杨敏桑胜波张强张博叶王晓圆
Owner TAIYUAN UNIV OF TECH
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