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Barium titanate piezoelectric ceramic support for bone tissue engineering and preparation method thereof

A technology of bone tissue engineering and piezoelectric ceramics, applied in the field of materials science, can solve problems such as the inability to precisely control the internal structure and pore connectivity of the scaffold, and achieve improved biological performance, good biological activity and piezoelectricity, and molding process simple effect

Active Publication Date: 2021-11-26
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of these methods can precisely control the internal structure and pore connectivity of scaffolds.

Method used

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  • Barium titanate piezoelectric ceramic support for bone tissue engineering and preparation method thereof
  • Barium titanate piezoelectric ceramic support for bone tissue engineering and preparation method thereof
  • Barium titanate piezoelectric ceramic support for bone tissue engineering and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A barium titanate piezoelectric ceramic support for bone tissue engineering, the specific steps are:

[0031] Step 1: Disperse 20g of barium titanate nanoparticles with a particle size of ≤1 micron in 100mL of ethanol, add 5mL of acetic acid with a molar concentration of 17.5mol / L to activate, stir for 30min, and after ultrasonic treatment for 30min, add 8g of Tetraethyl silicate, add ammonia water with a molar concentration of 14.8mol / L to adjust the pH value to 9, stir, then add 2g of calcium nitrate tetrahydrate, stir at 40°C for 4h, collect the solid by centrifugation and wash until neutral, bake at 60°C dry to obtain barium titanate powder coated with bioactive glass (BTO@BG), the bioactive glass is evenly coated on the surface of barium titanate, and the mass ratio of barium titanate and bioactive glass is 100:15.

[0032] Step 2: Mix 70wt% of barium titanate powder coated with bioactive glass, 20wt% ethanol, and 10wt% of binder polyvinylpyrrolidone (K60), stir qu...

Embodiment 2

[0037] A barium titanate piezoelectric ceramic support for bone tissue engineering, the specific steps are:

[0038] Step 1: Disperse 20g of barium titanate nanoparticles with a particle size of ≤1 micron in 100mL of ethanol, add 5mL of acetic acid with a molar concentration of 17.5mol / L to activate, stir for 30min, and after ultrasonic treatment for 30min, add 5g of normal Tetraethyl silicate, add ammonia water with a molar concentration of 14.8mol / L to adjust the pH value to 9.5, stir, then add 1.5g calcium nitrate tetrahydrate, stir at 40°C for 4h, collect the solid by centrifugation and wash until neutral, bake at 60°C dry to obtain barium titanate powder coated with bioactive glass (BTO@BG), the bioactive glass is uniformly coated on the surface of barium titanate, and the mass ratio of barium titanate and bioactive glass is 100:10.

[0039]Step 2: Mix 75wt% of barium titanate powder coated with bioactive glass, 10wt% ethanol, and 15wt% of binder polyvinylpyrrolidone (K60...

Embodiment 3

[0044] A barium titanate piezoelectric ceramic support for bone tissue engineering, the specific steps are:

[0045] Step 1: Disperse 20g of barium titanate nanoparticles with a particle size of ≤1 micron in 100mL of ethanol, add 5mL of acetic acid with a molar concentration of 17.5mol / L to activate, stir for 30min, and after ultrasonic treatment for 30min, add 3g of normal Tetraethyl silicate, add ammonia water with a molar concentration of 14.8mol / L to adjust the pH value to 8.5, stir, then add 0.8g calcium nitrate tetrahydrate, stir at 40°C for 4h, collect the solid by centrifugation and wash until neutral, bake at 60°C dry to obtain barium titanate powder coated with bioactive glass (BTO@BG), the bioactive glass is uniformly coated on the surface of barium titanate, and the mass ratio of barium titanate and bioactive glass is 100:20.

[0046] Step 2: Mix 60wt% of barium titanate powder coated with bioactive glass, 15wt% ethanol, and 25wt% of binder polyvinylpyrrolidone (K3...

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Abstract

The invention provides a barium titanate piezoelectric ceramic support for bone tissue engineering, which is characterized in that it comprises: 60-80wt% barium titanate powder coated with bioactive glass, 10-20wt% ethanol, 5 ‑15wt% binder polyvinylpyrrolidone is mixed and stirred to obtain printing ink; use 3D modeling software to design a porous model with a porosity of 50%‑90%, and perform 3D printing to obtain a porous stent green body; the porous stent green body Sintering in a tube furnace to obtain a barium titanate piezoelectric ceramic scaffold for bone tissue engineering. The invention uses barium titanate coated with bioactive glass as a raw material, and adopts three-dimensional printing technology to prepare a porous composite ceramic support, which has good biological activity and piezoelectricity, can accurately control the internal structure of the support, and has a simple forming process.

Description

technical field [0001] The invention belongs to the field of materials science, and specifically relates to a barium titanate piezoelectric ceramic support for bone tissue engineering and a preparation method thereof. Background technique [0002] As the most promising method in the field of bone defect repair, bone tissue engineering has been widely recognized. Its proposal and development have changed the traditional treatment mode of bone defect repair. Bone tissue engineering includes three basic elements—cells, scaffold materials, and signaling molecules. Scaffold materials, as the most basic carrier materials for constructing bone tissue engineering, play a very important role in bone tissue engineering. In addition, studies have shown that physical stimuli such as ultrasonic stimulation, pulse electrical stimulation, and direct current stimulation can also promote the repair of bone defects. Their mechanism of action is to promote the expression of genes related to os...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10A61L27/50C04B35/468C04B35/622C04B35/628C04B35/63C04B38/00C04B41/00B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/10A61L27/50B33Y10/00B33Y70/00B33Y80/00C04B35/468C04B35/622C04B35/62802C04B35/6303C04B38/0041C04B41/00C04B41/009C04B2235/3208C04B2235/36C04B2235/6026C04B2235/656C04B2235/6562
Inventor 朱敏何鑫
Owner UNIV OF SHANGHAI FOR SCI & TECH
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