A kind of phosphodiesterase-4 inhibitor pharmaceutical composition for treating oral ulcer and preparation method thereof
A technology for phosphodiesterase and oral ulcers, which is applied in drug combination, drug delivery, and pharmaceutical formulations. Good effect
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Embodiment 1
[0027] Table 1 Composition of lyotropic liquid crystal drug carrier 1
[0028] prescription composition %(w / w) Apst 0.5 Glyceryl dioleate 15 Lecithin 30 Ethanol 15 Propylene Glycol 15 Tween 80 20 Menthol 4.5
[0029] Preparation Process:
[0030] a) adding glyceryl dioleate to the stainless steel container, adding propylene glycol and stirring continuously with a screw mixer, mixing evenly, for subsequent use;
[0031] b) slowly adding the apremilast crude drug to the ethanol, and adding Tween 80 to fully dissolve the crude drug, then adding citric acid while stirring, mixing uniformly, for subsequent use;
[0032] c) adding the dissolved bulk drug to lecithin, and after stirring, slowly add the mixture of glycerol dioleate and propylene glycol, and stir evenly;
[0033] d) Put the above mixture in a water bath, the water bath temperature is 40-60°C, and the water bath time is 0.5-1h;
[0034] e) The mixture after th...
Embodiment 2
[0036] Table 2 Composition of lyotropic liquid crystal drug carrier 2
[0037] prescription composition %(w / w) Apst 3 Ethyl oleate 20 Lecithin 40 DMSO 6 glycerin 20 distilled water 5 citric acid 6
[0038] Preparation Process:
[0039] a) Add ethyl oleate into a stainless steel container, add glycerin and stir continuously with a screw mixer, mix well, and set aside;
[0040] b) dissolving apremilast drug substance in DMSO, fully dissolving;
[0041] c) adding the dissolved bulk drug to lecithin, stirring evenly, slowly adding a mixture of ethyl oleate and glycerol, placing it in a water bath at 50-70°C, then adding distilled water to the above mixture, stirring and mixing well;
[0042]d) The mixed mixture is centrifuged for 10-20 minutes to remove air bubbles, and then placed at 25-37° C. for a week to equilibrate to obtain a stable lyotropic liquid crystal drug carrier.
Embodiment 3
[0044] Table 3 Oral Gel Composition 1
[0045] prescription composition Proportion in prescription (%) Apst 0.5 DMSO 2 Poloxamer 70 Triethanolamine 3 glycerin 20 peppermint 4.5
[0046] Preparation Process:
[0047] a) dissolve the poloxamer in water to make it fully swollen, then adjust the pH to neutrality with a pH adjuster, add glycerin and grind sufficiently to make it wet;
[0048] b) after dissolving apremilast in DMSO, slowly add it to a), grind while adding, and add an appropriate amount of distilled water to make it a gelling agent with suitable viscosity;
[0049] c) Add peppermint oil, and triethanolamine to b), grind to make it appear as a transparent gel, and smell fragrant.
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