Titanium-based active bone implant and preparation method thereof
A bone implantation and active technology, applied in the direction of prosthesis, coating, tissue regeneration, etc., can solve problems such as limitations, and achieve the effect of promoting bone-related cell osteogenic differentiation and good ability
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[0032] Example 1
[0033] Preparation of titanium-based active bone implant
[0034] (1) Dissolve 0.47 g of p-nitrobenzoic acid ester in 15 mL of tetrahydrofuran, and fill with nitrogen at 0°C to obtain solution I;
[0035] (2) Dissolve 0.5g 4-(hydroxymethyl)phenylboronic acid pinacol ester, 0.04g 4-dimethylaminopyridine and 0.6mL triethylamine in 5mL tetrahydrofuran to obtain solution II;
[0036] (3) Under ice bath conditions, add solution I in step (1) dropwise to solution II in step (2) under stirring for 10 minutes, then stir and react at room temperature at 600r / min for 3h, spin dry Then dissolve the spin-dried product with dichloromethane to obtain a yellow solution, wash with 1M HCl, saturated NaCl solution, and then NaHCO 3 The solution was washed until the color of the yellow solution became light yellow, and finally passed through a silica gel column, followed by a mixture of petroleum ether and dichloromethane in a volume ratio of 1:4, and petroleum ether and dichlorometha...
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[0041] Example 2
[0042] Preparation of titanium-based active bone implant
[0043] (1) Dissolve 0.47 g of p-nitrobenzoic acid ester in 15 mL of tetrahydrofuran, and fill with nitrogen at 0°C to obtain solution I;
[0044] (2) Dissolve 0.5g 4-(hydroxymethyl)phenylboronic acid pinacol ester, 0.04g 4-dimethylaminopyridine and 0.6mL triethylamine in 5mL tetrahydrofuran to obtain solution II;
[0045] (3) Under ice bath conditions, add solution I in step (1) dropwise to solution II in step (2) with stirring over 20 minutes, and then stir at room temperature at 300r / min for 4h, spin dry Then dissolve the spin-dried product with dichloromethane to obtain a yellow solution, wash with 1M HCl, saturated NaCl solution, and then NaHCO 3 The solution was washed until the color of the yellow solution became light yellow, and finally passed through a silica gel column, followed by a mixture of petroleum ether and dichloromethane in a volume ratio of 1:4, and petroleum ether and dichloromethane in ...
Example Embodiment
[0049] Example 3
[0050] Preparation of titanium-based active bone implant
[0051] (1) Dissolve 0.47 g of p-nitrobenzoic acid ester in 15 mL of tetrahydrofuran, and fill with nitrogen at 0°C to obtain solution I;
[0052] (2) Dissolve 0.5g 4-(hydroxymethyl)phenylboronic acid pinacol ester, 0.04g 4-dimethylaminopyridine and 0.6mL triethylamine in 5mL tetrahydrofuran to obtain solution II;
[0053] (3) Under ice bath conditions, add solution I in step (1) dropwise to solution II in step (2) under stirring for 15 minutes, then stir and react at room temperature at 800r / min for 3h, and spin to dry Then dissolve the spin-dried product with dichloromethane to obtain a yellow solution, wash with 1M HCl, saturated NaCl solution, and then NaHCO 3 The solution was washed until the color of the yellow solution became light yellow, and finally passed through a silica gel column, followed by a mixture of petroleum ether and dichloromethane in a volume ratio of 1:4, and petroleum ether and dichlo...
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