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Titanium-based active bone implant and preparation method thereof

A bone implantation and active technology, applied in the direction of prosthesis, coating, tissue regeneration, etc., can solve problems such as limitations, and achieve the effect of promoting bone-related cell osteogenic differentiation and good ability

Active Publication Date: 2019-11-12
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] α-Melanocyte-stimulating hormone (α-MSH) is a biologically active molecule that can promote the expression of cAMP. Some studies have shown that it can promote the osteogenic differentiation of osteoblasts (MC3T3-E11), but due to its The concentration required for the action is relatively high, so the use of materials is very limited

Method used

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  • Titanium-based active bone implant and preparation method thereof
  • Titanium-based active bone implant and preparation method thereof
  • Titanium-based active bone implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Preparation of titanium-based active bone implants

[0034] (1) Dissolve 0.47g of p-nitrobenzoic chloroformate in 15mL of tetrahydrofuran, and fill with nitrogen at 0°C to obtain solution I;

[0035] (2) 0.5g 4-(hydroxymethyl) phenylboronic acid pinacol ester, 0.04g 4-dimethylaminopyridine and 0.6mL triethylamine were dissolved in 5mL tetrahydrofuran to obtain solution II;

[0036] (3) Under ice bath conditions, add solution I in step (1) dropwise to solution II in step (2) through 10 min under stirring, then stir the reaction at room temperature at a speed of 600 r / min for 3 h, spin dry Afterwards, the spin-dried product was dissolved in dichloromethane to obtain a yellow solution, which was washed with 1M HCl and saturated NaCl solution successively, and then washed with NaHCO 3 The solution was washed until the color of the yellow solution turned light yellow, and finally passed through a silica gel column, followed by a mixture of petroleum ether and dichloromethan...

Embodiment 2

[0042] Preparation of titanium-based active bone implants

[0043] (1) Dissolve 0.47g of p-nitrobenzoic chloroformate in 15mL of tetrahydrofuran, and fill with nitrogen at 0°C to obtain solution I;

[0044] (2) 0.5g 4-(hydroxymethyl) phenylboronic acid pinacol ester, 0.04g 4-dimethylaminopyridine and 0.6mL triethylamine were dissolved in 5mL tetrahydrofuran to obtain solution II;

[0045] (3) Under ice bath conditions, add solution I in step (1) dropwise to solution II in step (2) through 20min under stirring, then stir the reaction at room temperature at a speed of 300r / min for 4h, spin dry Afterwards, the spin-dried product was dissolved in dichloromethane to obtain a yellow solution, which was washed with 1M HCl and saturated NaCl solution successively, and then washed with NaHCO 3 The solution was washed until the color of the yellow solution turned light yellow, and finally passed through a silica gel column, followed by a mixture of petroleum ether and dichloromethane i...

Embodiment 3

[0050] Preparation of titanium-based active bone implants

[0051] (1) Dissolve 0.47g of p-nitrobenzoic chloroformate in 15mL of tetrahydrofuran, and fill with nitrogen at 0°C to obtain solution I;

[0052] (2) 0.5g 4-(hydroxymethyl) phenylboronic acid pinacol ester, 0.04g 4-dimethylaminopyridine and 0.6mL triethylamine were dissolved in 5mL tetrahydrofuran to obtain solution II;

[0053] (3) Under ice bath conditions, add solution I in step (1) dropwise to solution II in step (2) through 15min under stirring, then stir the reaction at room temperature at a speed of 800r / min for 3h, spin dry Afterwards, the spin-dried product was dissolved in dichloromethane to obtain a yellow solution, which was washed with 1M HCl and saturated NaCl solution successively, and then washed with NaHCO 3 The solution was washed until the color of the yellow solution turned light yellow, and finally passed through a silica gel column, followed by a mixture of petroleum ether and dichloromethane i...

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Abstract

The invention relates to a titanium-based active bone implant and a preparation method thereof, which belong to the technical field of a medical material. The method comprises the following steps: after dopamine is loaded on the surface of pure titanium, a gelatin solution, a dextran amine solution, a gelatin solution, an alpha-melanocyte stimulating hormone solution are subjected to spin coatingin order, wherein spin coating of the gelatin solution, the dextran amine solution, the gelatin solution, and the alpha-melanocyte stimulating hormone solution in order is called the complete spin coating, the number of complete spin coatings is determined according to the actual required release amount of the alpha-melanocyte stimulating hormone, a layer of the gelatin solution is spin-coated after the last complete spin coating is completed, and the material immersed in a solution of a graft polymer formed by grafting right-arm polyethylene glycol amino group with a boric acid ester bond formore than 2 h to prepare the titanium-based active bone implant. The bone implant can release a large amount of alpha-MSH in a short time to reach the effect concentration, and has the ability to promote osteogenic differentiation of bone-related cells. The preparation method of the titanium-based active bone implant is simple and easy to operate, and is suitable for expanding production.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a titanium-based active bone implant and a preparation method thereof. Background technique [0002] Titanium implants have been widely used in clinical orthopedic implant surgery due to their good mechanical properties and biocompatibility. However, due to some defects of titanium implant itself, it is difficult to achieve perfect therapeutic effect in clinical application, such as surface metal ion extravasation, elastic modulus mismatch, lack of osteoinductivity and other defects, which make it harmful to bone quality. Repair of loose fractures is more difficult. [0003] In order to quickly integrate the implant with the surrounding bone tissue, techniques such as acid-base corrosion, micro-arc oxidation, plasma spraying, and layer-by-layer self-assembly have been introduced into the surface modification of bone implants. Under physiological conditions...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/34A61L27/54
CPCA61L27/06A61L27/34A61L27/54A61L2300/252A61L2300/412A61L2300/604A61L2420/06A61L2420/08A61L2430/02C08L89/00C08L5/02
Inventor 胡燕陈茂华蔡开勇罗忠
Owner CHONGQING UNIV
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