Method for purifying injection sodium chloride

Abstract

The invention discloses a method for purifying injection sodium chloride and relates to the technical field of medicine product preparation. The method comprises the following steps: firstly, dissolving a crude salt into pure water, performing ultrafiltration or microfiltration to remove macromolecule organic matters, colloids and particulates in the solution, and further performing treatment by using filtrate of a secondary nanofiltration system so as to effectively remove sulfate radicals in the solution with the combination of two stages of nanofiltration systems; and pumping a penetratingfluid of the nanofiltration systems into an evaporation tank, performing vapor heating in the process, controlling the vapor pressure to 0.1-0.15Mpa, converting the nanofiltration system penetrating fluid to be saturated from being unsaturated, performing crystallization separation on sodium chloride, performing further purification while the sodium chloride is separated out, and finally performing filtration, drying and packaging. In the whole process, ultrafiltration / microfiltration and nanofiltration systems are combined, treatment is implemented through a membrane method process completely, the process is simple, the effluent quality is stable, control is easy, automation can be easily achieved, , and the sodium chloride which is obtained through refining finally is low in impurity content and is capable of completely meeting indexes of injection.

Description

technical field [0001] The invention relates to the technical field of preparation of medical supplies, in particular to a method for purifying sodium chloride for injection. Background technique [0002] The main treatment of sodium chloride injection: dehydration caused by various reasons, including hypotonic, isotonic and hypertonic dehydration; hypertonic non-ketotic diabetic coma, application of isotonic or hypotonic sodium chloride Can correct dehydration and isotonic state; hypochloremic metabolic alkalosis. Sodium chloride injection is a traditional medicine commonly used clinically in the medical field in various countries in the world. When the patient uses it, it directly enters the blood circulation system through intramuscular injection. Since the coarse salt sodium chloride contains many harmful impurities, if If it is not removed, it will cause many complications and cause damage to the patient's body if it enters the blood. Although there are many chemical f...

AI Technical Summary

Problems solved by technology

Disadvantages of this process: 1. Adding barium chloride and sodium carbonate requires a feeding tank, which occupies a large area and is complicated to operate; 2. It needs to add the reagents barium chloride and sodium carbonate twice. Barium chloride itself is toxic and will increase Reagent cost; 3. Use the precipitation method to remove sulfate, so the removal rate of sulfate is not high, and the sulfate cannot be completely removed; 4. Using two distillations, the distillation temperature needs to be 130 degrees, which will require high energy consumption. Thus increasing the cost; 5. During the crystallization process, some substances with similar solubility such as sodium sulfate and some metal cations exist in the crystals and cannot be removed

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