Multi-responsive shape memory urethane acrylate copolymer and preparation method thereof

A technology of urethane acrylate and copolymer, which is applied in the field of preparation of urethane acrylate-based copolymers, and can solve problems such as not found

Active Publication Date: 2019-11-22
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, no similar material has been found in the existing documents.

Method used

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  • Multi-responsive shape memory urethane acrylate copolymer and preparation method thereof
  • Multi-responsive shape memory urethane acrylate copolymer and preparation method thereof
  • Multi-responsive shape memory urethane acrylate copolymer and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0030] The preparation of PUA prepolymer is:

[0031] (1) Synthesis of polycaprolactone polyol: Add 1,4-butanediol and ε-caprolactone in a round bottom flask, BDO: ε-CL molar ratio is 1:16, catalyst stannous octoate, pass into N 2 Raise the temperature to 130°C, react for 24 hours, and stop the reaction. Pour the obtained product into n-hexane and anhydrous ether for centrifugal purification, and dry it in a vacuum oven at 50°C for 24 hours to obtain PCL long-chain diol with a molecular weight of 2000.

[0032] (2) Preparation of PUA prepolymer: Put 0.01mol of PCL long-chain diol in a three-necked flask, heat it to 100°C and vacuumize it with a circulating water pump for 2 hours to remove moisture, then cool down to 50°C and add 0.02mol dropwise using a constant pressure separatory funnel HDI monomer and organic bismuth catalyst, toluene was added dropwise to reduce the viscosity of the system, nitrogen gas was introduced to remove the air in the flask, and the temperature w...

Embodiment 1

[0034]Weigh 4g of PUA prepolymer, add 1g of NIPAM monomer into a disposable plastic cup, add 10ml of DMF solvent and ultrasonically mix evenly, drop 0.5g of AAc monomer into the mixture, add 0.055g of PI184, stir to mix evenly , pour it into a polytetrafluoroethylene mold (80mm × 80mm × 1mm), use a PET film cover to remove the air on the surface and make the surface smooth, irradiate under a UV lamp for 20min, take out the film, rinse it with acetone solvent 3-5 times, and place Take it out in a vacuum oven at 50°C for 24 hours and cut it to the required size.

[0035] The prepared copolymer film was tested by XRD and DSC, and the drug release of tetracycline was studied to observe its shape memory effect.

Embodiment 2

[0037] Weigh 4g of PUA prepolymer, add 1g of NIPAM monomer into a disposable plastic cup, add 10ml of DMF solvent and ultrasonically mix evenly, drop 0.75g of AAc monomer into the mixture, add 0.058g of PI184, stir to mix evenly , pour it into a polytetrafluoroethylene mold (80mm × 80mm × 1mm), use a PET film cover to remove the air on the surface and make the surface smooth, irradiate under a UV lamp for 20min, take out the film, rinse it with acetone solvent 3-5 times, and place Take it out in a vacuum oven at 50°C for 24 hours and cut it to the required size.

[0038] The prepared copolymer film was tested by XRD and DSC, and the drug release of tetracycline was studied to observe its shape memory effect.

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Abstract

The invention relates to a multi-response polyurethane acrylate (PUA)-based copolymer and a preparation method thereof. The preparation method comprises the following steps: uniformly mixing a PUA prepolymer, N-isopropylacrylamide and an acrylic monomer according to a certain ratio in an N,N-methylene acrylamide (DMF) solvent, adding a photoinitiator, and irradiating the mixture under an ultraviolet lamp to initiate free radical polymerization, thereby obtaining the multi-response copolymer. According to the invention, an active diluent is added on the basis of PUA for cross-linking copolymerization, and chain segments interact with each other to inhibit crystallization, so that a glass transition region with a relatively wide temperature interval is obtained, and a multiple shape memory effect is obtained on the basis of an original PUA single shape memory cycle (SMC). Due to the compact cross-linked structure, the hydrogel also has a slow-release effect in the aspect of drug release,and is expected to be used in the field of biomedicine.

Description

technical field [0001] The invention relates to a preparation method of a multi-response polyurethane acrylate (PUA)-based copolymer. Background technique [0002] Shape memory polyurethane (SMPU), as a class of smart materials with broad application prospects, has attracted more and more attention. This kind of material has a special ability to obtain a temporary shape under the action of external stress, and can fix the deformation at a lower temperature, and then resist the external environment (such as heat, light, moisture, electricity and magnetic field, etc.) Spontaneously return to its pre-deformed shape upon stimulation. It is this attractive performance that gives SMPUs great potential for wide application in smart fabrics, smart packaging, biomedical devices, sensors, and actuators. [0003] Thermosensitive SMPU can be regarded as a two-phase structure, that is, a stationary phase that can remember the initial shape and a reversible phase that can undergo revers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F283/00C08F220/54C08F220/06C08F2/48C08G18/67C08G18/42
CPCC08F2/48C08F283/008C08G18/4277C08G18/672C08G2280/00C08F220/54C08F220/06C08G18/42
Inventor 张嵘任文惠徐德锋盛扬孙一新
Owner CHANGZHOU UNIV
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