Antibacterial self-repairing hydrogel as well as preparation method and application thereof
A self-healing and antibacterial technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical science. Longevity, good biocompatibility and long-term activity
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[0040] The embodiment of the present invention also discloses the preparation method of antibacterial hydrogel, comprising the following steps:
[0041]a, copolymerization, 200 parts by weight of N-(3-dimethylaminopropyl) methacrylamide and 10~300 parts (preferably 20~100 parts) of diacetone acrylamide are dissolved in a solvent, and the Free radical copolymerization (preferably controlled free radical polymerization), the reaction temperature is 30~120°C (preferably 60~100°C), the reaction time is 2~24h (preferably 12~24h), after the polymerization is completed, add to the reaction solution Add a precipitating agent to remove the residual monomer by precipitation to obtain N-(3-dimethylaminopropyl) methacrylamide and diacetone acrylamide copolymer. Wherein, the solvent used is N,N-dimethylformamide, dioxane or dimethyl sulfoxide, and the amount of solvent used is 120-1000 parts.
[0042] b, quaternization, the obtained N-(3-dimethylaminopropyl) methacrylamide and diacetone a...
Embodiment 1
[0045] Copolymerization: 20 g N-(3-dimethylaminopropyl) methacrylamide, 20 g diacetone acrylamide, 30 mg azobisisobutyronitrile (AIBN) and 300 mg DDMAT chain transfer agent (i.e. dodecyltri Thiocarbonate) was dissolved in 40 mL of dioxane, and it was added to a 100 mL reaction flask. After removing the oxygen in the system, the temperature was raised to 60°C under magnetic stirring to perform reversible addition-fragmentation chain transfer radical polymerization. The reaction time is 24 hours. After the reaction is over, cool the reaction system, precipitate twice with petroleum ether, remove the unreacted monomer, and dry it in vacuum to obtain a white powder, which is N-(3-dimethylaminopropyl) methacrylic acid Amide-diacetone acrylamide copolymer, weighted calculation of monomer conversion rate and average molecular weight, the mass ratio of repeating unit N-(3-dimethylaminopropyl) methacrylamide to repeating unit diacetone acrylamide in the copolymer About 50:50.
[0046]...
Embodiment 2
[0054] Copolymerization: 20 g N-(3-dimethylaminopropyl) methacrylamide, 15 g diacetone acrylamide, 27 mg azobisisobutyronitrile (AIBN) and 270 mg DDMAT chain transfer agent (i.e. dodecyltri Thiocarbonate) was dissolved in 35 mL of dioxane, and added to a 100 mL reaction flask. After removing the oxygen in the system, the temperature was raised to 60°C under magnetic stirring to perform reversible addition-fragmentation chain transfer radical polymerization. The reaction time is 24 hours. After the reaction is over, cool the reaction system, precipitate twice with petroleum ether, remove the unreacted monomer, and dry it in vacuum to obtain a white powder, which is N-(3-dimethylaminopropyl) methacrylic acid Amide-diacetone acrylamide copolymer, weighted calculation of monomer conversion rate and average molecular weight, the mass ratio of repeating unit N-(3-dimethylaminopropyl) methacrylamide to repeating unit diacetone acrylamide in the copolymer About 20:10.
[0055] Quater...
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