Method for producing ibuprofen through multistage continuous reaction crystallization
A technology of reaction crystallization and secondary reaction, which is applied in the field of medicine and chemical industry, can solve the problems of product purity specification and small crystal particle size, and achieve the effect of high main content of the product, uniform particle size and obvious effect
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Embodiment 1
[0036] The sodium ibuprofen aqueous solution is used as the raw material, and hydrochloric acid is used for multi-stage reaction crystallization, and the formed ibuprofen crystal slurry is continuously discharged, and then enters the processes of separation, washing, drying, etc. to prepare the finished ibuprofen product. The concrete steps of the production method of its continuous crystallization are:
[0037] (1) Reaction into oil: continuously adding concentration to the oil tank is the ibuprofen sodium salt aqueous solution of 0.06g / ml, at the same time, the hydrochloric acid aqueous solution is added in the oil tank, the pH value of the oil tank is controlled at 6.9, and the feed liquid The temperature is controlled at 40°C, and the average residence time of the oil-forming tank based on the ibuprofen sodium salt aqueous solution feed is 0.5 hours;
[0038] (2) First-stage reaction crystallization: The oil-forming tank continuously transports materials to the first-stage...
Embodiment 2
[0043] The sodium ibuprofen aqueous solution is used as the raw material, and phosphoric acid is used for multi-stage reaction crystallization, and the formed ibuprofen crystal slurry is continuously discharged, and then enters the separation, washing, drying and other processes to prepare the finished ibuprofen product. The concrete steps of the production method of its continuous crystallization are:
[0044] (1) Reaction into oil: Continuously adding concentration to the oil tank is the ibuprofen sodium salt aqueous solution of 0.09g / ml, at the same time, adding phosphoric acid aqueous solution in the oil tank, the pH value of the oil tank is at 6.7, the feed liquid temperature Controlled at 35°C, the average residence time of the oil-forming tank based on the ibuprofen sodium salt aqueous solution feed is 0.5 hours;
[0045] (2) Primary reaction crystallization: Add the seed crystals with 0.05-0.1% ibuprofen sodium salt content in the raw material liquid flowing into the p...
Embodiment 3
[0051] The sodium ibuprofen aqueous solution is used as the raw material, and acetic acid is used for multi-stage reaction crystallization, and the formed ibuprofen crystal slurry is continuously discharged, and then enters the next steps of separation, washing, drying and other processes to prepare ibuprofen finished products. The concrete steps of the production method of its continuous crystallization are:
[0052] (1) Reaction into oil: Continuously adding concentration to the oil tank into the ibuprofen sodium salt solution of 0.07g / ml, the stock material flows into the oil tank from the top of the oil tank in the form of a distribution coil, and at the same time , add the acetic acid aqueous solution into the oil forming tank, and the acetic acid aqueous solution is also fed into the oil forming tank from the top of the oil forming tank in the form of a distribution coil. The pH value of the forming oil tank is 6.7, and the liquid temperature is 35°C. The average residen...
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