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Carbon dot-based fluorescent silicon dioxide nanosphere and preparation method thereof

A technology of silica and nanospheres, applied in chemical instruments and methods, luminescent materials, etc., can solve problems such as low luminescence quantum yield and molar absorption coefficient, restrictions on the large-scale application of quantum dots, and threats to the toxic environment. Effects of low cytotoxicity, surface modification, and low cost

Active Publication Date: 2020-01-10
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, due to its high concentration in the silica matrix, even a small leakage of the dye can lead to serious pollution of the environment and harm to living things
II-VI and III-V semiconductor quantum dots are usually composed of heavy metal ions, which are inherently toxic and pose environmental threats, thus limiting the large-scale application of such quantum dots, especially in vivo
Lanthanide nanocrystals have relatively low luminescence quantum yields and molar absorption coefficients, making them unsuitable for fluorescent silica spheres

Method used

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  • Carbon dot-based fluorescent silicon dioxide nanosphere and preparation method thereof
  • Carbon dot-based fluorescent silicon dioxide nanosphere and preparation method thereof
  • Carbon dot-based fluorescent silicon dioxide nanosphere and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0037] Example 1 Preparation of carbon dot-based fluorescent silica nanospheres

[0038] (1) Pour 15mL of N-β-(aminoethyl)-γ-aminopropyltrimethoxysilane into a 50mL three-necked flask, and after purging with nitrogen for a period of time, heat the solution to 240°C. Quickly add 0.075, 1, 2, 4, 6, 7.5 g of dehydrated citric acid under stirring. After reacting for 5 minutes, stop heating and cool the solution naturally, and centrifuge the obtained solution at high speed to remove large particles at the bottom to obtain silanization Carbon dots. The silylated carbon dots obtained by different quality dehydrated citric acid only affect the concentration of carbon dots in the final product but not the properties of carbon dots. Among them, the pictures of silanized carbon dots obtained by adding 1g of dehydrated citric acid under fluorescent lamp and ultraviolet lamp are as follows: figure 1 As shown, its quantum yield is 47%.

[0039] (2) Add 68 mg of triethanolamine to 25 mL o...

Embodiment 2

[0041] Example 2 Preparation of carbon dot-based fluorescent silica nanospheres

[0042] The difference between this embodiment and Example 1 is: the quality of dehydrated citric acid in the step of preparing silylated carbon points in step (1) is 1g, and the time of reaction heating is respectively 1, 3, 7, 10, 15, 20, 30min. Others are the same as in Example 1. Different reaction heating times only affect the concentration of carbon dots in the final product but not the properties of carbon dots.

Embodiment 3

[0044] The difference between this example and Example 1 is that the quality of dehydrated citric acid in the step of preparing silylated carbon dots in step (1) is 1 g, and in step (2) 10 mg of triethanolamine, 100 mg of CTAB, 10 mg of sodium salicylate and TEOS 1mL. Others are the same as in Example 1, the morphology of the fluorescent nanospheres obtained is the same as Figure 4 similar.

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Abstract

The invention discloses a carbon dot-based fluorescent silicon dioxide nanosphere and a preparation method thereof. The preparation method comprises the following steps: (1) synthesizing silanized carbon dots by utilizing citric acid and a silanization reagent; (2) stirring triethanolamine, hexadecyltrimethylammonium bromide and sodium salicylate in water for a certain period of time, injecting tetraethyl orthosilicate, performing continuous stirring for a certain period of time, and washing off a template by using hydrochloric acid to obtain a dendritic silicon dioxide nanosphere; and (3) uniformly mixing the silanized carbon dots and the dendritic silicon dioxide nanosphere in water or ethanol according to a certain ratio, and performing catalysis with ammonia water to obtain the carbondot-based fluorescent silicon dioxide nanosphere. The preparation method has the characteristics of simple process, low cost and the like, and the prepared fluorescent nanosphere has the advantages ofuniform size, uniformity in carbon dot doping, high fluorescence property and high stability.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a carbon point-based fluorescent silica nanosphere and a preparation method thereof. Background technique [0002] Carbon dot-based fluorescent silica nanospheres are non-invasive and biocompatible silica spheres with fluorescence. Because of its advantages of integrating large surface area and high luminescence in a single nanoplatform, it has attracted extensive attention and has been intensively studied. It can simultaneously realize effective drug delivery, cell tracking and even diagnosis. [0003] In order to fully understand the panorama of fluorescent silica spheres in ultrasensitive fluorescence / color-coded analysis and biological imaging, the construction of fluorescent silica spheres should meet the following criteria simultaneously: the luminescent substances within the template are uniformly distributed and well protected, Maximum fluorescent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/65
CPCC09K11/025C09K11/65
Inventor 丁收年徐来弟
Owner SOUTHEAST UNIV
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