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A sustained-release composition for treating animal skin parasites and fungal infections

A slow-release composition and fungal infection technology, which can be used in drug combinations, anti-infective drugs, skin diseases, etc., can solve the problems of unreasonable dosage design of injections, difficulty in actual production transfer, and poor stability, and achieve animal administration compliance. Good sex, controllable cost, good effect of drug action

Active Publication Date: 2022-01-14
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The anti-mite drugs currently on the market can only kill the adults and larvae of the mites, and are ineffective against the eggs, which are easy to cause repeated infection, and generally need to be used more than twice; antifungal drugs mostly inhibit the growth of sensitive fungal hyphae and cannot kill bacteria. Usually need to continue medication for more than 1 week
Patent CN1210040C (2003-09-25) discloses a method for preparing joint slow-release powder or injection for preventing and treating animal skin ringworm and acariasis by inclusion of β-cyclodextrin, but the invention has complicated process and low encapsulation efficiency. Poor, unreasonable injection dose design, undetermined effect, poor stability, and difficulty in actual production conversion, Merial Longrange in 2011 TM (5% acetaminobamectin in situ gel injection) has been approved by the FDA for the long-acting (effective period of 100-150 days) treatment of lung nematodes and roundworms in cattle, and the original gel drugs in other anti-parasitic fields are still In development and research stage

Method used

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  • A sustained-release composition for treating animal skin parasites and fungal infections
  • A sustained-release composition for treating animal skin parasites and fungal infections
  • A sustained-release composition for treating animal skin parasites and fungal infections

Examples

Experimental program
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Effect test

Embodiment 1

[0035] A sustained-release composition for treating animal skin parasites and fungal infections, according to the mass of feeding, for every 50L prepared, the composition of its raw materials is as follows:

[0036]

[0037] Preparation:

[0038] (1) 10g of tert-butyl p-hydroxyanisole and 5g of dibutyl hydroxytoluene are dissolved in 20L of dimethyl sulfoxide, then add 2500g of acetaminophen and 2500g of amphotericin B, Stir until completely dissolved to obtain the first mixed solution;

[0039] (2) Add 25L of dimethyl sulfoxide into the liquid mixing tank, add 5000g of polylactic acid glycolic acid into the liquid mixing tank, stir to mix evenly, and leave overnight until the texture is uniform and clear, to obtain a polymer solution;

[0040] (3) Under the condition of continuous stirring, add the first mixed solution and 150 g of dexamethasone acetate into the polymer solution, stir until it is completely clear, and then add dimethyl sulfoxide to the production volume t...

Embodiment 2

[0042] A sustained-release composition for treating animal skin parasites and fungal infections, according to the mass of feeding, for every 50L prepared, the composition of its raw materials is as follows:

[0043]

[0044] Preparation:

[0045](1) The propyl gallate of 8g is dissolved in the benzyl alcohol of 2500g, then add the ivermectin of 1500g and the amphotericin B of 1500g, add N-methylpyrrolidone to dissolve completely while stirring, obtain the first mixture;

[0046] (2) Add 12.5L of N-methylpyrrolidone into the liquid mixing tank, add 2500g of polylactic acid into the liquid mixing tank, stir to mix evenly, and leave overnight until the texture is uniform and clear to obtain a polymer solution;

[0047] (3) Under the condition of continuous stirring, add the first mixed solution and 100 g of dexamethasone acetate into the polymer solution, stir until it is completely clear, and then add N-methylpyrrolidone to the production volume to obtain the product.

Embodiment 3

[0049] A sustained-release composition for treating animal skin parasites and fungal infections, according to the mass of feeding, for every 50L prepared, the composition of its raw materials is as follows:

[0050]

[0051]

[0052] Preparation:

[0053] (1) Dissolve 5g of dibutyl hydroxytoluene and 10g of tert-butyl hydroquinone in an appropriate amount of N,N-dimethylformamide, then add 1000g of abamectin and 3000g of amphotericin B , stirred until completely dissolved to obtain the first mixed solution;

[0054] (2) Add 20L of N,N-dimethylformamide into the liquid mixing tank, add 4000g of polylactic acid glycolic acid into the liquid mixing tank, stir to mix evenly, and let it stand overnight until the texture is uniform and clear, and the polymerized substance solution;

[0055] (3) Under the condition of continuous stirring, add the first mixed solution and 250g of dexamethasone acetate into the polymer solution, stir until it is completely clear, and then add N...

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Abstract

The invention discloses a slow-release composition for treating animal skin parasites, especially mites and fungal infections, as well as its preparation method and application. High characteristics, significantly superior to existing treatment combinations. The anti-parasitic component abamectins, the anti-fungal component amphotericin B, and the drug combination of dexamethasone acetate have a higher dual effect realization rate; the in-situ gel sustained-release preparation form ensures that the composition lasts longer. Effective and safe. The preparation process of the composition of the present invention is simple; the implementation mode of single administration within the course of treatment makes the drug compliance of animals better, and further achieves the purpose of treating combined skin infection. The sustained-release composition of the present invention is in the form of intramuscular or subcutaneous injection. Can be used on furry animals, especially cats or dogs.

Description

technical field [0001] The invention relates to the field of animal-specific pharmaceutical preparations, in particular to a long-acting, sustained-release in-situ gel for skin mites, fungal infections or mixed infections of hairy animals, a preparation method and application thereof. Background technique [0002] Acariasis and ringworm are two skin diseases with the highest clinical incidence in animals. Scabies in economic animals can lead to hair loss, thickened skin, loss of appetite or no food, weight loss, anemia, and decreased immunity in affected animals, which seriously affects their economic benefits; clinically, most pets are mixed skin infections of mites and fungi Disease, difficult diagnosis, long treatment cycle, high recurrence rate, unsatisfactory treatment effect and other problems directly affect the appearance of pets, and at the same time bring great mental and economic burdens to pet owners. [0003] Abamectin antiparasitic drugs have the characteristi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K9/06A61K31/7048A61K31/365A61K31/573A61K47/34A61K47/32A61P33/14A61P31/10A61P17/00
CPCA61K9/08A61K9/06A61K31/7048A61K31/365A61K31/573A61K47/34A61K47/32A61P33/14A61P31/10A61P17/00
Inventor 张朋丽谢玲玲陈博强李梁刘爱玲李守军
Owner RINGPU TIANJIN BIOLOGICAL PHARMA