Phytosterol ester microcapsule and preparation method and application thereof

The technology of phytosterol ester and phytosterol is applied in the field of phytosterol ester microcapsule and its preparation, which can solve the problems of easy oxidative deterioration of core material, uneven particle size, short drying process, etc., and achieves good emulsification effect and improved water solubility. , the effect of high stability

Active Publication Date: 2020-01-24
广东蔚莱生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The spray drying method has a short drying process, which can avoid the loss of biological activity caused by long-term heating; good dispersion, high purity, high solubility, low cost, and easy transportation and storage; the process is easy to operate and conducive to continuous production, so it is widely used, but , the disadvantage is that the particle size is not uniform, and some of them are sunken and broken; the core material adsorbed on the surface is easy to oxidize and deteriorate

Method used

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  • Phytosterol ester microcapsule and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) be 2% vitamin C aqueous solution as water phase with mass fraction, phytosterol ester is as oil phase, 50g water phase is joined in the 60g oil phase phytosterol ester, then add 2g emulsifier lecithin and phytosterol ( The mass ratio of lecithin and phytosterol is 1:1), and dispersed at 12000r / min for 5min to obtain a W / O emulsion;

[0041] (2) Mixing gum arabic and pectin in a mass ratio of 1:4 to obtain a mixed colloid; then dissolving the mixed colloid in water to obtain a mixed colloid solution, wherein the mass fraction of the mixed colloid is 1.5%;

[0042](3) under stirring condition, the W / O emulsion that 44g step (1) makes is slowly added in the 38g mixed colloid solution, mixes, and then adding 10g massfraction is 1.5% chitosan acetic acid solution (chitosan Sugar molecular weight is 150,000), mix evenly, obtain mixed system;

[0043] (4) adjusting the pH of the reaction system in step (3) to 3.5, stirring and reacting at 30°C for 8h, then standing at 4°C...

Embodiment 2

[0046] (1) be the vitamin C aqueous solution of 0.5% as water phase with mass fraction, phytosterol ester is as oil phase, 60g water phase is joined in the 60g oil phase phytosterol ester, then add 3g emulsifier lecithin and phytosterol ( The mass ratio of lecithin and phytosterol is 2:3), dispersed at 10000r / min for 10min to obtain W / O emulsion;

[0047] (2) Mixing gum arabic and pectin in a mass ratio of 1:3 to obtain a mixed colloid; then dissolving the mixed colloid in water to obtain a mixed colloid solution, wherein the mass fraction of the mixed colloid is 1%;

[0048] (3) under stirring condition, slowly join in the W / O emulsion that 45g step (1) makes in the 35g mixed colloid solution, mix well, then add 10g massfraction again and be 1% chitosan acetic acid solution (chitosan Sugar molecular weight is 150,000), mix evenly, obtain mixed system;

[0049] (4) adjusting the pH of the reaction system in step (3) to 4.0, stirring and reacting at 25°C for 12h, then standing...

Embodiment 3

[0052] (1) be the vitamin C aqueous solution of 5% as water phase with mass fraction, phytosterol ester is as oil phase, 40g water phase is joined in the 60g oil phase phytosterol ester, then add 0.5g emulsifier lecithin and phytosterol (The mass ratio of lecithin and phytosterol is 4:3), dispersed at 11000r / min for 4min to obtain W / O emulsion;

[0053] (2) Mixing gum arabic and pectin in a mass ratio of 1:5 to obtain a mixed colloid; then dissolving the mixed colloid in water to obtain a mixed colloid solution, wherein the mass fraction of the mixed colloid is 2%;

[0054] (3) under stirring condition, slowly join the W / O emulsion that 52.5g step (1) makes in the 32g mixed colloid solution, mix well, then add 10g massfraction again and be the chitosan acetic acid solution of 2% (shell The molecular weight of the polysaccharide is 150,000), mixed evenly to obtain a mixed system;

[0055] (4) adjusting the pH of the reaction system in step (3) to 3.8, stirring and reacting at ...

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Abstract

The invention belongs to the field of fine chemical industry, and particularly relates to a phytosterol ester microcapsule and a preparation method and application thereof. According to the method, avitamin C aqueous solution is used as a water phase, phytosterol ester is used as an oil phase, a stable W / O emulsion is prepared by assisting of an emulsifier, then the W / O emulsion is used as a corematerial, negatively charged polymers arabic gum and pectin, and a positively charged polymer chitosan are used as a wall material, and a complex coacervation reaction is carry out to obtain the stable phytosterol ester microcapsule. The microcapsule is resistant to high-temperature and high-humidity, and has the slow-release effect, the method is simple, and the reaction is mild.

Description

technical field [0001] The invention belongs to the field of fine chemicals, and in particular relates to a phytosterol ester microcapsule, a preparation method and application thereof. Background technique [0002] Phytosterol is a natural active substance existing in plants, which is similar in structure to animal sterols such as cholesterol, and widely exists in various vegetable oils, nuts, plant seeds, vegetables and fruits. There are many kinds of natural phytosterols, mainly including β-sitosterol, stigmasterol, brassicasterol and campesterol. Phytosterol esters are prepared from phytosterols and fatty acids through esterification, and have better fat solubility than free phytosterols, better fat solubility and better blood cholesterol lowering effect than phytosterols. The U.S. FDA has approved that foods added with phytosterols or phytosterol esters can use the "healthy" label. At the same time, the FDA has made a statement based on research reports that a daily in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J13/04A61K9/50A61K31/575A61K47/22A61K47/28A61P39/06A61K31/375A23L33/105A23K10/30
CPCA23V2002/00A61K9/5036A61K31/375A61K31/575A61K47/22A61K47/28A23K10/30A23L33/105A61P39/06B01J13/02B01J13/043A23V2200/30A23V2250/2136
Inventor 孙凤刚邹胜龙李志华潘忠超
Owner 广东蔚莱生物科技有限公司
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