Screening method of antimicrobial peptide and application of screening method

A screening method and antibacterial peptide technology, applied in the field of antibacterial peptides, can solve the problems of long antibacterial peptide peptide chain, high synthesis cost, low biological activity of natural antibacterial peptides, etc., and achieve small molecular weight, high bactericidal activity, cytotoxicity and hemolytic toxicity. low effect
CN110734474AActive Publication Date: 2020-01-31SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2020-01-31

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Abstract

The invention relates to the technical field of antibacterial peptide, in particular to a screening method of the antimicrobial peptide and an application of the screening method, and discloses a screening method of the antimicrobial peptide. In accordance with specific pathogenic bacteria, the screening method can quickly screen the antibacterial peptide having excellent resistance. The polypeptide molecular weight in a bacteriophage random peptide library selected in the screening method is small, so that the screened antibacterial peptide is small in molecular weight, and easy to obtain bya chemosynthesis method, and the production cost of the antibacterial peptide is reduced. The antibacterial peptide screened by the screening method has high bactericidal activity for pathogenic bacteria, and the cytotoxicity and the hemolytic activity are low.
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Description

technical field

[0001] The invention relates to the technical field of antimicrobial peptides, in particular to a method for screening antimicrobial peptides and applications thereof. Background technique

[0002] Since the successful industrialization of penicillin in 1938, the research and development of antibiotics has entered a period of rapid development. Antibiotics have treated countless patients with bacterial or fungal infections and made great contributions to human health. However, with the inappropriate use of antibiotics and the absence of antibiotic management, many bacteria are resistant to antibiotics, which makes antibiotic treatment ineffective. Bacterial drug resistance has seriously threatened human health. According to the data from the China Bacterial Resistance Detection Network, in the first half of 2018, the situation of domestic bacterial resistance to antibacterial drugs is still relatively severe, especially carbapenem-resistant Gram-negative bac...

Claims

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