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An external gel patch for treating arthritis

A gel patch and arthritis technology, applied in the direction of fern/filamentous plant medical raw materials, anti-inflammatory agents, medical preparations with non-effective ingredients, etc., can solve the problems of inconvenient taking and large side effects, etc. Achieve the effect of reducing individual differences, high compliance, and good transdermal absorption effect

Active Publication Date: 2021-08-03
JIANMIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of external gel patch for the treatment of arthritis in view of the existing oral Chinese patent medicines with large side effects and inconvenient taking.

Method used

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  • An external gel patch for treating arthritis
  • An external gel patch for treating arthritis
  • An external gel patch for treating arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023] 138g of scutellaria, 104g of dog ridge, 104g of Shenjincao, 104g of Gentiana chinensis, 70g of Caulis Spatholobus, 104g of Fangji, 70g of geranium, 104g of mulberry branch, 52g of Wujiapi, 52g of Duhuo.

[0024] Preparation:

[0025] 1) The above medicinal materials were first distilled with water for 6 hours, and the volatile oil was collected for later use, and then continued to be decocted with water for 3 times, each time for 1 hour, and the two extracts were combined and concentrated into a thick paste with a relative density of 1.20 (cold measurement). To room temperature, add ethanol to make the alcohol content reach 40% (weight), after stirring evenly, let it settle down, get the supernatant and concentrate to a thick paste whose relative density is 1.35 (cold measurement).

[0026] 2) Prepare the gel matrix, the auxiliary materials are as follows:

[0027] Sodium polyacrylate 200g, polyvinylpyrrolidone 50g, crospovidone 50g, aluminum hy...

Embodiment 2

[0031] Prescription is identical with embodiment 1.

[0032] Preparation method:

[0033] 1) The above medicinal materials were first distilled with water for 8 hours, and the volatile oil was collected for later use, and then continued to be decocted and extracted twice, each time for 2 hours, and the two extracts were combined and concentrated into a thick paste with a relative density of 1.15 (cold measurement). To room temperature, add ethanol to make the alcohol content reach 70% (weight), after stirring evenly, let it settle down, get the supernatant and concentrate to a thick paste whose relative density is 1.35 (cold measurement).

[0034] 2) Prepare the gel matrix, the auxiliary materials are as follows:

[0035] Sodium polyacrylate 300g, polyvinylpyrrolidone 30g, crospovidone 30g, aluminum hydroxide 30g, citric acid 20g, glycerin 1000g, sorbitol 30g, propylene glycol 300g, laurocaprone 150g, edetate disodium 15g, ethylparaben 15g, menthol 30g, purified water 2500g....

Embodiment 3

[0039] Prescription is identical with embodiment 1.

[0040] Preparation method:

[0041] 1) Distill the above medicinal materials with water for 10 hours, collect the volatile oil for later use, then continue to add water to decoct and extract 4 times, the first time is 1.5 hours, the second time is 1 hour, the third time and the fourth time are 0.5 hours each, and combined twice The extract is also concentrated into a thick paste with a relative density of 1.10 (cold measurement), cooled to room temperature, added ethanol to make the alcohol content reach 55% (by weight), stirred well, left to settle, and the supernatant is concentrated to a relative density A thick paste of 1.35 (cold test).

[0042] 2) Prepare the gel matrix, the auxiliary materials are as follows:

[0043] Sodium polyacrylate 450g, polyvinylpyrrolidone 15g, crospovidone 15g, aluminum hydroxide 40g, citric acid 40g, glycerin 1200g, sorbitol 15g, propylene glycol 150g, laurocaprolactone 180g, edetate diso...

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Abstract

The invention discloses an external gel patch for treating arthritis, which is obtained by modifying the dosage form of the existing Joint Fengtong Pill. The present invention changes the dosage form of the existing oral Chinese medicine for the treatment of arthritis into an external gel patch, avoiding the first-pass effect of the liver and the adverse reaction of the medicine to the gastrointestinal tract, and at the same time reducing the individual differences in medicine, and improving the treatment efficiency of the disease. The blood concentration of the drug at the site can be more quickly and accurately exerted curative effect. Compared with the existing drugs, the present invention also has the advantages of convenient use and high compliance.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to an external gel patch for treating arthritis. Background technique [0002] CN1823910A discloses a traditional Chinese medicine preparation for rheumatic musculoskeletalgia, arthralgia, and numbness of limbs. The standard, the standard number WS3-B-1126-92, is made of 10 Chinese herbal medicines such as Juxtapatus chinensis, Dogji, Shenjincao, and Gentiana chinensis. The preparation method on the ministerial standard is to use 70% ethanol to leak and extract the scorpion grass, Gentiana chinensis, and Duhuo; grind Wujiapi and Fangji into fine powder; The herb is decocted with water to extract and made into pills. [0003] The existing dosage forms are all oral preparations. In clinical application, the drug has strong analgesic, anti-inflammatory and anti-swelling activities, but it is also easy to cause obvious gastrointestinal adverse reactions such as nausea, vomiting, ab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605A61K9/70A61P19/02A61P29/00
CPCA61K9/7023A61K36/11A61K36/12A61K36/185A61K36/232A61K36/254A61K36/28A61K36/486A61K36/515A61K36/59A61K36/605A61K47/32A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P19/02A61P29/00A61K2300/00
Inventor 熊登科赵刚熊莉吴木琴李霞朱雯聂芳王灵均冷姣龙
Owner JIANMIN PHARMA GRP CO LTD
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