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Four-Huang dysentery-stopping microcapsule and preparation method thereof

A technology for stopping dysentery and coptis, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of slow dissolution, poor palatability, drug resistance, etc., and achieve increased compliance, good stability, and the use of spleen and stomach digestion Effect

Inactive Publication Date: 2020-02-21
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current Sihuang Zhili Granules show drug resistance; and in clinical use, they dissolve slowly and have poor palatability

Method used

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  • Four-Huang dysentery-stopping microcapsule and preparation method thereof
  • Four-Huang dysentery-stopping microcapsule and preparation method thereof
  • Four-Huang dysentery-stopping microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A Sihuang antidiarrheal microcapsule, comprising the following components in parts by mass:

[0032] 28 parts of thick cream, 45 parts of PEG4000, 12 parts of PEG6000, 15 parts of astragalus polysaccharide;

[0033] The thick ointment is prepared from the following raw materials in parts by mass: 200 parts of Coptis chinensis, 200 parts of Cortex Phellodendri, 100 parts of Rhubarb, 200 parts of Scutellaria baicalensis, 200 parts of Radix Radix, 100 parts of licorice, 100 parts of honeysuckle and 100 parts of gardenia.

[0034] A preparation method of Sihuang antidysentery microcapsules, comprising the following steps:

[0035] (1) Add water to decoct Coptis chinensis, cortex cortex, rhubarb, scutellaria baicalensis, isatidis, licorice, honeysuckle and gardenia twice, the first time for 2 hours, the second time for 1 hour, combine the decoctions, filter, and take the filtered supernatant The liquid is concentrated under reduced pressure to obtain a thick paste with a re...

Embodiment 2

[0039] A Sihuang antidiarrheal microcapsule, comprising the following components in parts by mass:

[0040] 25 parts of thick cream, 45 parts of PEG4000, 15 parts of PEG6000, 15 parts of astragalus polysaccharide;

[0041] The thick ointment is prepared from the following raw materials in parts by mass: 200 parts of Coptis chinensis, 200 parts of Cortex Phellodendri, 100 parts of Rhubarb, 200 parts of Scutellaria baicalensis, 200 parts of Radix Radix, 100 parts of licorice, 100 parts of honeysuckle and 100 parts of gardenia.

[0042] A preparation method of Sihuang antidysentery microcapsules, comprising the following steps:

[0043] (1) Add water to decoct Coptis chinensis, cortex cortex, rhubarb, scutellaria baicalensis, isatidis, licorice, honeysuckle and gardenia twice, the first time for 2 hours, the second time for 1 hour, combine the decoctions, filter, and take the filtered supernatant The liquid is concentrated under reduced pressure to obtain a thick paste with a re...

Embodiment 3

[0047] A Sihuang antidiarrheal microcapsule, comprising the following components in parts by mass:

[0048] 20 parts of thick cream, 45 parts of PEG4000, 15 parts of PEG6000, 20 parts of astragalus polysaccharide;

[0049] The thick ointment is prepared from the following raw materials in parts by mass: 200 parts of Coptis chinensis, 200 parts of Cortex Phellodendri, 100 parts of Rhubarb, 200 parts of Scutellaria baicalensis, 200 parts of Radix Radix, 100 parts of licorice, 100 parts of honeysuckle and 100 parts of gardenia.

[0050] A preparation method of Sihuang antidysentery microcapsules, comprising the following steps:

[0051](1) Add water to decoct Coptis chinensis, cortex cortex, rhubarb, scutellaria baicalensis, isatidis, licorice, honeysuckle and gardenia twice, the first time for 2 hours, the second time for 1 hour, combine the decoctions, filter, and take the filtered supernatant The liquid is concentrated under reduced pressure to obtain a thick paste with a rel...

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Abstract

The invention belongs to the field of treatment of chicken colibacillosis, and discloses a four-Huang dysentery-stopping microcapsule. The microcapsule comprises the following components: a thick paste, an emulsifier and astragalus polysaccharide, wherein the thick paste is prepared from the following raw materials: coptis chinensis, golden cypress, rheum officinale, scutellaria baicalensis, isatis roots, liquorice, honeysuckles and cape jasmine. According to the invention, traditional Chinese medicines and western preparation are adopted, the preparation process is simple, re-drying is not needed, the production cost is saved, effective components can be fully extracted, auxiliary materials are added to prepare the microcapsule, the inherent bitter taste of traditional Chinese medicinal materials can be covered, the taste is improved, the dissolubility is good, and the bioavailability is high. The four-Huang dysentery-stopping microcapsule has the advantages of reasonable proportion,convenient operation, good content uniformity, good stability, high yield, good taste and good treatment effect.

Description

technical field [0001] The invention relates to the field of treating chicken colibacillosis, in particular to a Sihuang antidiarrheal microcapsule and a preparation method thereof. Background technique [0002] Chicken colibacillosis is an acute and chronic bacterial infectious disease of various chickens caused by pathogenic Escherichia coli, which can occur in chickens of all breeds and ages, seriously affecting the development of the chicken industry. In recent years, with the continuous development of the breeding industry to a large scale, many farmers have blindly increased the amount of breeding, resulting in the deterioration of the breeding environment. Drugs can be used to prevent and control the disease of chickens. The commonly used drugs are mostly antibiotics. However, in recent years, it has been found that Escherichia coli is extremely resistant to drugs, such as penicillin, streptomycin, oxytetracycline, tetracycline and other antibiotics. There is almost n...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/50A61K47/36A61P1/14A61P31/04A61P37/04A61K31/715
CPCA61K9/1652A61K31/715A61K36/195A61K36/315A61K36/355A61K36/484A61K36/539A61K36/708A61K36/718A61K36/744A61K36/756A61P1/14A61P31/04A61P37/04A61K2300/00
Inventor 陈艺青刘肖娟王俊谭志坚黎剑坤符德文黄显会
Owner FOSHAN STANDARD BIO TECH
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