Cryoprotectant based on liquid metal nanoparticles as well as method and application of cryoprotectant

A technology of cryoprotectant and liquid metal, which is applied in the field of biomedicine to achieve the effect of uniform particle size distribution, reduced damage, and large application prospects
CN110839613AActive Publication Date: 2020-02-28TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2020-02-28

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Abstract

The invention relates to a cryoprotectant based on liquid metal nanoparticles as well as a method and an application of the cryoprotectant. The cryoprotectant comprises the liquid metal nanoparticlesand a basic protectant, wherein the melting point of the raw material of the liquid metal nanoparticles is below 60 DEG C, and the basic protective agent is a mixture of ethylene glycol, propylene glycol and trehalose. The cryoprotectant can realize vitrification in the cooling process, and can be used as a space heat source under the irradiation of near-infrared laser in the rewarming process, thereby greatly enhancing the heating rate, inhibiting anti-vitrification, reducing the formation of ice crystals, and enhancing the survival rate and structural integrity of cryopreserved cells and vascular tissues.
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Description

Technical field

[0001] The present invention relates to the field of biomedicine, in particular to a cryoprotectant based on liquid metal nanoparticles, and a method and application thereof. Background technique

[0002] Cryopreservation is the only method for long-term preservation of valuable cells to maintain cell functional properties (such as immunomodulatory ability, differentiation ability) and reach the number required for clinical applications. Recently, various methods for cryopreservation have been developed, including slow freezing and vitrification. The slow freezing method is time-consuming and usually requires expensive program cooling equipment to achieve the required cooling rate. Compared with slow freezing, because vitrification is a freezing mode that quickly reduces the cell temperature, it avoids the mechanical damage to the cells during the slow freezing process, while shortening the freezing processing time, simplifying the steps, and eliminating the need...

Claims

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