Mulberry leaf powder-mulberry silk sericin/tussah silk fibroin blending film and preparation method thereof

A technology of mulberry leaf powder and tussah silk, which is applied in the field of materials, can solve the problems of unsuitable medical dressings, insufficient tensile properties, and no antibacterial properties, and achieve skin wound healing, excellent antibacterial effects, and hydrophilicity strong effect

Active Publication Date: 2020-02-28
SOUTH CHINA AGRI UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as patent CN201010119912.2 provides a kind of tussah silk peptide-gelatin blend film, which can be used as packaging material and edible as nutrients, but it is not suitable for medical dressing, because tussah silk peptide is Obtained after hydrolysis with acid, alkali or enzyme, the peptide bond is broken, its molecular weight is small, resulting in poor film-forming properties, insufficient tensile properties, and no antibacterial properties

Method used

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  • Mulberry leaf powder-mulberry silk sericin/tussah silk fibroin blending film and preparation method thereof
  • Mulberry leaf powder-mulberry silk sericin/tussah silk fibroin blending film and preparation method thereof
  • Mulberry leaf powder-mulberry silk sericin/tussah silk fibroin blending film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] MLP-MSS / TSF-BF of different mulberry leaf powder additions of embodiment 1

[0056] 1. Test method

[0057] (1) Preparation of silkworm sericin solution: Weigh 10 g of silkworm cocoon shells, put them into 120 mL of distilled water, reflux at 100° C. for 30 minutes, and collect the sericin solution by filtration to obtain a sericin solution with a concentration of 4.50 μg / mL. °C refrigerator for use.

[0058] (2) Preparation of tussah silk fibroin solution: 180 g of calcium nitrate tetrahydrate crystals were weighed, heated and stirred at 80° C. for 30 min to obtain molten calcium nitrate. Use a measuring cylinder to measure 100mL of molten calcium nitrate, pour it into a round bottom flask, weigh 10g of tussah silk fibroin fiber and add it, then place it in an oil bath, heat and stir at 120°C for 2 hours, cool it, and put it into the retentate Dialysis bags with a molecular weight of 8-10KDa were placed in running tap water for dialysis for two days, then in deionize...

Embodiment 2

[0071] 1. Test method

[0072] (1) With reference to the method in Example 1, prepare a sericin solution with a concentration of 1 μg / mL, a tussah silk fibroin solution with a concentration of 10 mg / mL, a gelatin solution with a concentration of 500 mg / mL, and mulberry leaf powder, and store them in a refrigerator at 4°C. ready for use.

[0073] (2) Take 4mL of the prepared sericin solution and silk fibroin solution with a volume ratio of 3:1, add 4mL polyethylene glycol 200, 2mL 500mg / mL gelatin, and then add 1% mulberry leaves to the formula powder, and formed a film after standing at room temperature for 48 hours.

[0074] 2. Experimental results

[0075] The dissolution loss rate of the prepared MLP-MSS / TSF-BF blend film is 57.4%, the elongation at break is 33.5%, and the breaking strength is 7.85kPa. The obtained MLP-MSS / TSF-BF also has a certain antibacterial effect active.

Embodiment 3

[0077] 1. Test method

[0078] (1) With reference to the method in Example 1, prepare a sericin solution with a concentration of 50 μg / mL, a tussah silk fibroin solution with a concentration of 50 mg / mL, a gelatin solution with a concentration of 100 mg / mL, and mulberry leaf powder, and store them in a refrigerator at 4°C for ready for use.

[0079] (2) Take 3 mL of the prepared sericin solution and silk fibroin solution with a volume ratio of 2:1, add 3 mL of polyethylene glycol 200, 1.5 mL of 100 mg / mL gelatin, and then add 1% mulberry Leaf powder, left at room temperature for 48 hours to form a film.

[0080] 2. Experimental results

[0081] The dissolution loss rate of the prepared MLP-MSS / TSF-BF blend film is 61%, the elongation at break is 35.5%, and the breaking strength is 8.05kPa. The obtained MLP-MSS / TSF-BF also has a certain antibacterial active.

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Abstract

The invention belongs to the technical field of biological materials, and discloses a mulberry leaf powder-mulberry silk sericin/tussah silk fibroin blending film (MLP-MSS/TSF-BF), a preparation method thereof and an application of the blending film. The preparation method of the blending film includes the steps: firstly, preparing mulberry silk sericin solution and tussah silk fibroin solution and uniformly mixing the mulberry silk sericin solution and the tussah silk fibroin solution; secondly, adding gelatin solution and polyethylene glycol 200 solution; finally, adding mulberry leaf powderto obtain mulberry leaf powder-mulberry silk sericin/tussah silk fibroin mixed liquid and drying the mixed solution to obtain the mulberry leaf powder-mulberry silk sericin/tussah silk fibroin blending film. The prepared blending film has excellent tensile properties and antibacterial activity and has an important application potential in the field of medical treatment and cosmetics.

Description

technical field [0001] The invention belongs to the technical field of materials. More specifically, it relates to a mulberry leaf powder-mulberry silk gum / tussah silk blend film and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body. It has functions such as temperature regulation, sensory absorption, and protection of tissues and organs in the body from various physical and chemical injuries and the invasion of germs and microorganisms. After the skin is injured (such as burns, mechanical trauma), it needs to be covered to reduce infection. Promoting wound healing, reducing the rate of wound infection, and preventing scarring are the directions of focus in medical research. Research has found that the properties of dressing materials are critical to wound healing. A good dressing can quickly seal the wound, promote the regeneration of various cells and tissue growth, restore the skin barrier function as soon as po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/32A61L15/26A61L15/42A61L15/44A61L15/46A61L15/62A61K8/9789A61K8/86A61K8/65A61K8/64A61K8/02A61Q19/00
CPCA61K8/0208A61K8/64A61K8/65A61K8/86A61L15/26A61L15/32A61L15/40A61L15/42A61L15/44A61L15/46A61L15/62A61L2300/30A61L2300/404A61Q19/00A61K8/9789C08L89/00C08L71/02
Inventor 陈芳艳林碧敏王新钟杨生林健荣戴宏彬周清萍何昌文
Owner SOUTH CHINA AGRI UNIV
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