Small molecule compound

A technology of small molecule compounds and compounds, applied in digestive system, organic chemistry, drug combination, etc.
CN110862376AInactive Publication Date: 2020-03-06TECHNODERMA MEDICINES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TECHNODERMA MEDICINES
Publication Date
2020-03-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a small molecule compound. The small molecule compound is characterized in that the small molecule compound is a compound shown in a structural formula in the specification, ora stereoisomer, a geometric isomer, a tautomer, a racemate, a hydrate, a solvate, a metabolite, and a pharmaceutically acceptable salt or pro-drug thereof, wherein X1 and X2 are selected from carbon or nitrogen; Z is carbon or nitrogen; n1 is 0 and 1; n2 and n3 are the same or different, and are 0 or any natural numbers; a cyclic group represented by G is a saturated heterocyclic ring; any one orseveral hydrogen atoms on the saturated heterocyclic ring are substituted by R; and R is selected from hydrogen, halogen, alkyl, substituted alkyl, amino, amine group, substituted amine group, carboxyl, amido, substituted amido, ester group, substituted carbonyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, substituted sulfonyl, and substituted sulfoxide group. The small molecule compound of the invention can be used to treat, prevent and alleviate autoimmune diseases and / or immune-related inflammatory skin diseases.
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Description

technical field

[0001] The present invention relates to the field of small molecule compounds, in particular to a small molecule compound and its derivatives that can be used to treat, prevent and alleviate autoimmune diseases and or immune-related inflammatory skin diseases. Background technique

[0002] The JAK (Janus Kinase)-STAT (Signal Transducer and Activator of Transcription proteins) signal transduction pathway is the main pathway for the intracellular transduction of signals stimulated by the combination of inflammatory cytokines and receptors. JAKs is a family of intracellular non-receptor tyrosine kinases (Tyrosine Kinase), including four members JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2). JAKs are mainly expressed in hematopoietic cells, leukocytes and intestinal epithelial cells, and are responsible for mediating the signal transmission of various cytokines involved in inflammatory responses. When cytokines bind to cell surface receptors, JAKs are activated ...

Claims

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