Application of cocamidopropyl PG-dimethylammonium chloride as micro-organism-inhibiting agent and application of the cocamidopropyl PG-dimethylammonium chloride as the micro-organism-inhibiting agent in daily chemical products

A kind of technology of dimethyl ammonium chloride and cocamidopropyl, applied in the application of cocamidopropyl PG-dimethyl ammonium chloride as bacteriostatic agent, and the application field of bacteriostatic agent in daily chemical products , can solve the problems such as no data to prove the effect, undisclosed cocamidopropyl PG-dimethyl ammonium chloride bactericidal property, etc., to achieve the effect of good bacteriostatic effect

Active Publication Date: 2020-03-31
马祥全
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Among them, the patent application number CN201710638891.7 (notice number CN107296771A) invention patent "An anti-dandruff composition and double-material multi-effect silicone-free shampoo" discloses an anti-dandruff composition and a double-material multi-effect silicone-free shampoo. Hair lotion, the shampoo contains DM-846, wherein DM-846 is a mixture of dichlorobenzyl alcohol, sodium isostearyl lactyl lactylate, cocamidopropyl PG-dimethyl ammonium chloride and sodium lactate, with Broad-spectrum high-efficiency bactericidal effect, has a strong antibacterial and bactericidal effect on scalp fungi, but it does not disclose the bactericidal effect of cocamidopropyl PG-dimethyl ammonium chloride, and there is no data to prove that DM The specific effects of each component in -846. Among the components, dichlorobenzyl alcohol is often used as a broad-spectrum antibacterial agent, sodium isostearyl lactylate is usually used as an emulsifier, and cocamidopropyl PG-di Methyl ammonium chloride is usually used as a conditioner for hair. Sodium lactate has a strong water absorption capacity and is often used as a moisturizer. Therefore, from the information provided in this text, it is generally believed that dichlorobenzyl alcohol has an antibacterial effect. Instead of Cocamidopropyl PG-Dimonium Chloride

Method used

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  • Application of cocamidopropyl PG-dimethylammonium chloride as micro-organism-inhibiting agent and application of the cocamidopropyl PG-dimethylammonium chloride as the micro-organism-inhibiting agent in daily chemical products
  • Application of cocamidopropyl PG-dimethylammonium chloride as micro-organism-inhibiting agent and application of the cocamidopropyl PG-dimethylammonium chloride as the micro-organism-inhibiting agent in daily chemical products
  • Application of cocamidopropyl PG-dimethylammonium chloride as micro-organism-inhibiting agent and application of the cocamidopropyl PG-dimethylammonium chloride as the micro-organism-inhibiting agent in daily chemical products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A

[0022] Measure the minimum inhibitory concentration of Cocamidopropyl PG-dimethylammonium chloride aqueous solution according to "Disinfection Technical Specifications" (2002 Edition) 2.1.8.3 Minimum Inhibitory Concentration Determination Test (Agar Dilution Method), and the test microorganisms are golden yellow Staphylococcus ATCC6538, Escherichia coli ATCC8739, Pseudomonas aeruginosa ATCC9027, Burkholderia cepacia ATCC25416, Enterobacter japonica ATCC33028, Candida albicans ATCC10231, Aspergillus niger ATCC16404.

[0023] The specific steps are as follows: take 5 g of the sample to be tested by aseptic operation, put it into 45 ml of sterilized PBS (0.03 mol / L phosphate buffer saline), fully shake and dissolve, and prepare a 10% uniformly dispersed solution. Then dilute it with PBS to obtain different concentrations of the test solution, and place it in a water bath at 45°C to 50°C for further use. Take 10ml of serially diluted antibacterial solution and add it to the plate....

Embodiment B1～B5

[0028] Add cocamidopropyl PG-dimethylammonium chloride aqueous solution to the wet tissue liquid with pH of 4.6, 5.5, and 6.5 respectively, and use it as a bacteriostatic agent, according to the method of the United States Pharmacopoeia USP32 (51) microbial antiseptic efficacy test Corrosion Challenge Test. The test microorganisms were Staphylococcus aureus ATCC6538, Escherichia coli ATCC8739, Pseudomonas aeruginosa ATCC9027, Enterobacter diaspora ATCC33028, Candida albicans ATCC10231, Aspergillus niger ATCC16404. Enterobacter versicolor is a common contaminating bacterium in daily chemical factories in South China, so this experiment deliberately added Enterobacter versicolor for testing. The concentration of the bacterial suspension was adjusted to 10 8 cfu / ml, in which equal amounts of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were mixed to form a mixed bacteria. The concentrations of the mold and yeast suspensions were adjusted to 10 7 cfu / ml, m...

Embodiment C

[0033] Add cocamidopropyl PG-dimethyl ammonium chloride aqueous solution to wet wipes containing non-woven fabrics (wet wipe liquid formula is 654-078Y) as a bacteriostatic agent, according to the United States Pharmacopoeia USP32 (51) microbial antiseptic Methods of Efficacy Testing Conduct a preservative challenge test.

[0034] See Table 4 and Table 5 for the wet wipe formula and test results of Example C.

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Abstract

The present invention discloses an application of cocamidopropyl PG-dimethylammonium chloride as a micro-organism-inhibiting agent and an application of the cocamidopropyl PG-dimethylammonium chlorideas the micro-organism-inhibiting agent in daily chemical products. Compared with the prior art, the present invention provides a new use of the cocamidopropyl PG-dimethylammonium chloride as the micro-organism-inhibiting agent, and besides, the cocamidopropyl PG-dimethylammonium chloride is used as the micro-organism-inhibiting agent applied in the field of the daily chemical products and has a good micro-organism-inhibiting effect.

Description

technical field [0001] The invention relates to the field of bacteriostasis technology, in particular to the application of cocamidopropyl PG-dimethyl ammonium chloride as a bacteriostat and its application in daily chemical products as a bacteriostat. Background technique [0002] Cocamidopropyl PG-dimethylammonium chloride phosphate, which is commonly used in the market, is a derivative of cocamidopropyl PG-dimethylammonium chloride, also known as natural bionic phospholipids, which is close to the skin It has good compatibility and has a certain repair function for damaged skin and hair. At the same time, it can replenish the phospholipids and oils lost by the skin. It is an extremely mild amphoteric surfactant, and some data show that it has broad-spectrum antibacterial properties. [0003] For example, the patent application No. CN201811235175.5 (the announcement number is CN109172480A) invention patent "A kind of anti-mite and anti-itch shampoo and its preparation proc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/42A61Q19/00A61Q19/10A61Q17/00A61P31/04A61P31/10
CPCA61K8/42A61Q19/00A61Q19/10A61Q17/005A61P31/04A61P31/10A61K2800/524A61K2800/10
Inventor 李梦茹莫路易孙山山熊洁何露
Owner 马祥全
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