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Preparation method and applications of antibacterial and biodegradable zinc alloy anastomosis nail

A zinc alloy and staple technology, applied in the directions of staples, staples, mechanical equipment, etc., can solve the problems of difficult processing of degradable magnesium alloy staples, unsuitable degradable zinc alloys, non-degradable staples, etc. Good deformability, low processing cost and suitable degradation rate

Pending Publication Date: 2020-04-17
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the problem that the staples made of inert metals such as titanium and titanium alloys used in clinical practice are not degraded, and overcome the problems of difficult processing and rapid degradation of the degradable magnesium alloy staples reported publicly. On the basis of breaking the technical prejudice that degradable zinc alloys are not suitable for use as staples, it innovatively provides a preparation method and application of biodegradable zinc alloy staples with good application prospects and antibacterial effects

Method used

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  • Preparation method and applications of antibacterial and biodegradable zinc alloy anastomosis nail
  • Preparation method and applications of antibacterial and biodegradable zinc alloy anastomosis nail

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A Zn-3wt%Cu alloy was machined into cylindrical billets for extruded wire. Graphite oil is coated on the surface of the die and the extruded wire blank as a lubricant before extrusion. The billets were extruded into filaments (1.5 mm in diameter) at a temperature of 180°C. The tensile strength of the filament is 240MPa, the yield strength is 200MPa, the elongation is 50%, and the corrosion rate in simulated body fluid is 0.04mm / year. The antibacterial rate for Escherichia coli and Staphylococcus aureus reaches 90%. The filaments were drawn for multiple passes to obtain filaments with a diameter of 0.2 mm. Carry out machining to above-mentioned wire material and obtain staple (such as figure 1 ), implanted into the stapler cartridge, sterilized and packaged to obtain the final product.

[0031] Prepare the wire into a B-shaped staple (such as figure 2), and then tie the two ends of the B-shaped staples with thin wires, one end of which is fixed on the tension gauge...

Embodiment 2

[0033] A Zn-3wt%Cu-1wt%Mn alloy was machined into a cylindrical billet for extruded wire. Graphite oil is coated on the surface of the die and the extruded wire blank as a lubricant before extrusion. The billets were extruded into filaments (1.5 mm in diameter) at a temperature of 180°C. The tensile strength of the filament is 350MPa, the yield strength is 240MPa, the elongation is 30%, and the corrosion rate in simulated body fluid is 0.06mm / year. The antibacterial rate for Escherichia coli and Staphylococcus aureus reaches 92%. The filaments were drawn for multiple passes to obtain filaments with a diameter of 0.3 mm. The above-mentioned wire is machined to obtain a staple, which is coated and implanted into a stapler cartridge, sterilized and packaged to obtain a final product.

[0034] Prepare the wire material into a B-shaped staple, and then fasten the two ends of the B-shaped staple with thin wires, one end of which is fixed on the tension gauge, and then pull the ot...

Embodiment 3

[0036] A Zn-5wt%Ag alloy was machined into cylindrical billets for extruded wire. Graphite oil is coated on the surface of the die and the extruded wire blank as a lubricant before extrusion. The billets were extruded into filaments (1.5 mm in diameter) at a temperature of 180°C. The tensile strength of the filament is 270MPa, the yield strength is 210MPa, the elongation is 45%, and the corrosion rate in simulated body fluid is 0.05mm / year. The antibacterial rate for Escherichia coli and Staphylococcus aureus reaches 95%. A filament with a diameter of 0.4 mm was obtained after drawing the filament for multiple passes. The above wire is machined to obtain staples, which are coated and drug-loaded, implanted into stapler cartridges, sterilized and packaged to obtain final products.

[0037] Prepare the wire material into a B-shaped staple, and then fasten the two ends of the B-shaped staple with thin wires, one end of which is fixed on the tension gauge, and then pull the oth...

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Abstract

The invention discloses a preparation method and applications of an antibacterial and biodegradable zinc alloy anastomosis nail, wherein the anastomosis nail is prepared from a biodegradable biomedical zinc alloy with antibacterial effect. The preparation method comprises the following steps: 1, preparing a wire material with a required size by utilizing a biodegradable zinc alloy with antibacterial effect; 2, preparing an anastomosis nail from the wire material obtained in the step 1; and 3, directly implanting the anastomosis nail obtained in the step 2 into a stapler nail bin, carrying outdisinfection treatment, and packaging to obtain the final application product, or further carrying out coating treatment and / or medicine carrying treatment, implanting into a stapler nail bin, carrying out disinfection treatment, and packaging to obtain the final application product. According to the invention, the preparation method is simple in process, the use is convenient after the prepared anastomosis nail is loaded into a medical stapler, the tightness is suitable, the rapid suture and the simple operation are guaranteed while the advantages of antibacterial property, surgical infectionprevention and the like are achieved, degradation and absorption are achieved, and the product can be widely applied to occasions needing tissue and organ suture in gastrointestinal and thoracic surgeries, vascular suture and other surgeries.

Description

technical field [0001] The invention relates to a preparation method and application in the field of biomaterial molding, in particular to a preparation method and application of an antibacterial and biodegradable zinc alloy staple. Background technique [0002] At present, staples are medical devices used in clinical operations to replace traditional manual suturing. Due to the fast suturing speed and relatively simple operation during surgery, it can significantly shorten the operation time and reduce the wound exposure time, thereby reducing the amount of bleeding during the operation and Effectively reduce surgical complications. However, the staples used in clinical applications are often made of inert metals such as titanium and titanium alloys, which do not degrade in the human body. After surgery, the staples exist as foreign objects in the human body for a long time, and even if they fall off, they are not easy to be excreted from the body. Therefore, There are cer...

Claims

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Application Information

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IPC IPC(8): A61B17/064C22C18/02C22C18/00A61L31/14A61L31/02A61L31/16A61L31/10A61L31/08
CPCA61B17/064A61B2017/00526A61B2017/00831A61B2017/00889A61L31/022A61L31/086A61L31/10A61L31/14A61L31/148A61L31/16A61L2300/102A61L2300/104A61L2300/404A61L2300/604C22C18/00C22C18/02C08L67/04
Inventor 黄华袁广银
Owner SHANGHAI JIAO TONG UNIV
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