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Bone repair and tumor suppression material with photothermal conversion performance and functional coating and preparation method

A photothermal conversion material and photothermal conversion technology, applied in coatings, pharmaceutical formulations, prostheses, etc., can solve the problems of life-threatening, single function, easy transfer of bone tumors, etc., to promote osseointegration, simple operation steps, The effect of inhibiting the growth of tumor cells

Active Publication Date: 2021-05-21
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing artificial bone materials prepared with polyetheretherketone (PEEK) as the main raw material are mainly to improve the biological activity of the material and take into account the mechanical strength (for example, "a preparation method of bone substitute material" disclosed in CN201310137210.0 ), so it has a single function and only has the function of bone repair
[0003] Bone tumors are tumors that occur in the bone or its subsidiary tissues, threatening people's lives. The current common treatment method is to resect the lesion area, but bone tumors are very easy to metastasize, which makes patients face the bone defect caused by tumor osteotomy again. risk

Method used

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  • Bone repair and tumor suppression material with photothermal conversion performance and functional coating and preparation method
  • Bone repair and tumor suppression material with photothermal conversion performance and functional coating and preparation method
  • Bone repair and tumor suppression material with photothermal conversion performance and functional coating and preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The processing steps of the present embodiment are as follows:

[0037] (1) Preparation of substrates with electrical conductivity and light-to-heat conversion properties

[0038] Weigh 24.0g of polyetheretherketone powder and place it in a beaker, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain a polyetheretherketone dispersion; weigh 6.0g of nanoscale graphene, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain a graphene dispersion , the number of nano-sheets of the nano-scale graphene is 1-5 layers, and the average radial size is 200 μm; the polyetheretherketone dispersion and the graphene dispersion are mixed together, ultrasonically dispersed for 30 minutes, filtered and dried Obtain uniformly mixed polyether ether ketone and graphene mixed powder; the polyether ether ketone and graphene mixed powder is molded into a circular truncated shape by injection molding, and the processing temperature is 370 ° C. Af...

Embodiment 2

[0050] The processing steps of the present embodiment are as follows:

[0051] (1) Preparation of substrates with electrical conductivity and light-to-heat conversion properties

[0052] Weigh 24.0g of polyetheretherketone powder and place it in a beaker, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain a polyetheretherketone dispersion; weigh 6.0g of nanoscale graphene oxide, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain graphene oxide Dispersion liquid, the number of nano-sheets of nano-scale graphene oxide is 1 to 5 layers, and the average radial size is 200 μm; the polyetheretherketone dispersion liquid and graphene oxide dispersion liquid are mixed together, ultrasonically dispersed for 30 minutes, and pumped Filtration and drying to obtain uniformly mixed polyetheretherketone and graphene oxide mixed powder; the polyether ether ketone and graphene oxide mixed powder is molded into a circular truncated shape by ...

Embodiment 3

[0062] The processing steps of the present embodiment are as follows:

[0063] (1) Preparation of substrates with electrical conductivity and light-to-heat conversion properties

[0064] Weigh 19.98g of polyetheretherketone powder and place it in a beaker, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain a polyether ether ketone dispersion; weigh 0.02g of nano-scale black phosphorus, add 100ml of ethanol, and disperse it ultrasonically for 30 minutes to obtain a black phosphorus dispersion ; Mix the polyether ether ketone dispersion and black phosphorus dispersion together, ultrasonically disperse for 30 minutes, and obtain a uniformly mixed polyether ether ketone and black phosphorus mixed powder through suction filtration and drying; mix polyether ether ketone and black phosphorus The mixed powder is formed into a circular truncated shape by 3D printing, and its processing temperature is 370 ° C. After cooling, a matrix with electrical conductivi...

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Abstract

The invention provides a preparation method of a bone repair and tumor suppression material with photothermal conversion performance and functional coating and the material obtained by the method. The process steps of the preparation method: (1) use polyetheretherketone powder and conductive and light-to-heat conversion material powder as raw materials, mix the two powders evenly and form the mixed powder into the desired shape, that is, to obtain a matrix with electrical conductivity and light-to-heat conversion properties; (2) in the case of The performance of the matrix surface is grafted with active functional groups, and then the matrix with active functional groups grafted on the surface is placed in the dispersion liquid as an electrode, and a functional coating is formed on the surface of the matrix by electrophoresis technology. The dispersion liquid consists of liquid Conductive medium, osseointegration-promoting substance and dispersant; (3) After the electrophoresis is completed, the material with a functional coating is washed with deionized water and then dried to remove the water on the surface to obtain a photothermal conversion performance and a functional coating. Materials for bone repair and tumor suppression.

Description

technical field [0001] The invention belongs to the field of artificial bone materials, and relates to a bone repairing and tumor suppressing material with light-to-heat conversion performance and functional coating, which uses polyether ether ketone as a main raw material and a preparation method thereof. Background technique [0002] Clinically, artificial bone materials are widely used in bone repair. Existing artificial bone materials include bioceramic materials, polymer materials and composite materials. Polyetheretherketone (PEEK) is a polymer composed of repeating units containing one ketone bond and two ether bonds in the main chain structure. It is a special polymer material. Due to its excellent mechanical properties, chemical corrosion resistance, and It can withstand repeated exposure to radiation and has biocompatibility, especially the modulus of elasticity is equivalent to that of human bone tissue, so it has attracted attention in the preparation of artific...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/50A61L27/54A61L27/08A61L27/12A61L27/28A61L27/32A61L27/30
CPCA61L27/08A61L27/12A61L27/18A61L27/28A61L27/306A61L27/32A61L27/50A61L27/54A61L2300/404A61L2300/416A61L2300/606A61L2400/12A61L2430/02C08L61/16
Inventor 毕瑞野何苗苗张利祝颂松侯毅
Owner SICHUAN UNIV
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