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A kind of self-assembled nanosphere and its preparation method and application

A nanosphere and self-assembly technology, applied in the field of self-assembled nanospheres and their preparation, preparation of slow-release food preservatives, can solve the problem that the microencapsulation technology cannot be widely used, the amount of oregano essential oil is not uniform, and the bacteriostatic effect is not balanced. and other problems, to achieve the effect of easy industrial scale-up, maintaining quality and good dispersibility

Active Publication Date: 2021-06-11
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The slow-release bactericidal and preservative for fruits and vegetables is packaged in a breathable non-woven bag and placed together with the fruits and vegetables, so that the amount of oregano essential oil that the fruits and vegetables come into contact with is not uniform, and the antibacterial effect is uneven.
[0005] Publication No. CN108185271A discloses a preparation method of a slow-release agricultural product fresh-keeping preservative, including the following steps: (1) Preparation of cross-linked starch: Step 1: Dissolving Span60 and Tween60 with cyclohexane to obtain the oil phase as the core material; step 2: dissolve potato starch with sodium hydroxide solution, then add cross-linking agent N-N methylenebisacrylamide to obtain starch solution as wall material; step 3: add starch solution to oil phase, after emulsification, add Potassium persulfate and sodium bisulfite react by heating to obtain cross-linked starch; (2) microencapsulation: press cumin essential oil: cross-linked starch=(2~7): 1ml / g, add cumin essential oil to step (1) In the prepared cross-linked starch, vibrate to obtain a microencapsulated slow-release preservative for agricultural products; but due to the high cost of microencapsulation technology, and a considerable part of the materials used as wall materials do not belong to the category of food additives , so microencapsulation technology cannot be widely used in the food industry

Method used

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  • A kind of self-assembled nanosphere and its preparation method and application
  • A kind of self-assembled nanosphere and its preparation method and application
  • A kind of self-assembled nanosphere and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0038] 1. Add sodium nitroprusside (SNP) to 0.3g / L graphene oxide nanoparticle dispersion, freeze-dry under ultrasonic conditions of frequency 30KHz and power 250W for 20min, and make nanoparticles;

[0039] 2. Immerse the nanoparticles in 30 mg / L chitosan acetic acid solution for 10 minutes, freeze-dry to obtain nanospheres;

[0040] 3. Repeat steps 1-2 to soak the nanospheres obtained in step 2 for a total of 10 times to obtain multi-layer coated nanospheres;

[0041] 4. Immerse the multi-layer coated nanospheres in 4,4'-diaminodiphenylstilbene-2,2'-disulfonic acid solution (DAS) for 20 minutes, freeze-dry, and irradiate with ultraviolet rays for 30 minutes to prepare nitrate SAN-SNP self-assembled nanospheres (Self-assembled nanospheres of SNP, SAN-SNP).

[0042] 5. Put the green mangoes in airtight containers, store at 1°C, hydrate the sodium nitroprusside self-assembled nanospheres into a film, and seal the container mouth.

[0043] Control group: green mango treated with...

Embodiment 2

[0048] 1. Adopt ion gel method to configure clove essential oil emulsion;

[0049] 2. Add 0.5g / L graphene oxide nanoparticle dispersion to the clove essential oil emulsion obtained in step 1, ultrasonicate for 30min under ultrasonic conditions with a frequency of 30KHz and a power of 250W, freeze-dry, and make nanoparticles;

[0050] 3. Immerse the nanoparticles in 20 mg / L chitosan acetic acid solution for 10 minutes, freeze-dry to obtain nanospheres;

[0051] 4. Repeat steps 2-3 for the nanospheres obtained in step 3, a total of 5 times, to obtain multilayer coated nanospheres;

[0052] 5. Immerse the multi-layer coated nanospheres in 4,4'-diaminodiphenylstilbene-2,2'-disulfonic acid solution (DAS) for 15 minutes, freeze-dry, and irradiate with ultraviolet light for 20 minutes;

[0053] 6. Put the peaches in an airtight container, use a nylon cloth bag to fill the self-assembled nanospheres of clove essential oil, and hang them above the container.

[0054] Control group: p...

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Abstract

The invention discloses a self-assembled nanosphere and a preparation method and application thereof, belonging to the technical field of food preservation. The self-assembled nanosphere uses a drug as a core layer and a chitosan-modified graphene oxide as a shell layer; the preparation method The method includes: immersing the drug in graphene oxide dispersion, ultrasonically, and freeze-drying to form nanoparticles; immersing the nanoparticles in chitosan ethanol solution and freeze-drying to obtain nanospheres; repeatedly immersing the nanospheres in graphene oxide to disperse liquid and chitosan ethanol solution, freeze-drying to obtain multi-layer coated nanospheres; dipping the multi-layer coated nanospheres in a photosensitive cross-linking agent, freeze-drying, and irradiating with ultraviolet rays to obtain self-assembled nanospheres. The self-assembled nanospheres prepared by the invention can coat a variety of hydrophobic drugs or volatile plant essential oils, so as to realize the selective release of the drugs and the precise regulation of the drug release rate.

Description

technical field [0001] The invention relates to the technical field of food preservation, in particular to a self-assembled nanosphere, a preparation method thereof and an application in the preparation of a slow-release food preservation agent. Background technique [0002] my country is a large agricultural production country with abundant fruit and vegetable resources. However, due to the high water content of fruits and vegetables, they are fresh and perishable foods. They are easy to be infected by pathogenic bacteria during storage and shelf life. In addition to refrigeration, controlled atmosphere storage and cold chain logistics transportation, supplementary sterilization treatment of fruit and vegetable products can extend the freshness period of fruits and vegetables. [0003] Among them, the natural bactericidal substances of plant essential oils extracted from plants have a complicated extraction process due to their low content in plants; compared with high-cost ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/04B01J13/20B82Y30/00A23B7/16
CPCA23B7/16B01J13/04B01J13/043B01J13/22B82Y30/00
Inventor 李莉王蕾罗自生
Owner ZHEJIANG UNIV