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Multifunctional specific biological bonding hydrogel as well as preparation method and application thereof

A specific and multi-functional technology, applied in bandages, medical science, etc., can solve the problems of dressings that cannot be removed, poor mechanical properties of viscous hydrogels, and biological safety issues, so as to achieve good biocompatibility and promote wound healing , to avoid cytotoxic effects

Active Publication Date: 2020-06-05
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Although there have been many studies on hydrogel wound dressings, the current common hydrogel dressings usually have the following deficiencies: first, viscous hydrogels often have poor mechanical properties, and require large movement deformation at joints, etc. For wounds in the site, viscous hydrogel dressings are prone to breakage due to insufficient mechanical properties
However, the dissolved dressing cannot be completely removed from the wound, and the addition of small molecules or metal ions will bring certain biological safety issues

Method used

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  • Multifunctional specific biological bonding hydrogel as well as preparation method and application thereof
  • Multifunctional specific biological bonding hydrogel as well as preparation method and application thereof
  • Multifunctional specific biological bonding hydrogel as well as preparation method and application thereof

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preparation example Construction

[0033] Based on the multifunctional specific bioadhesive hydrogel of the above embodiments, the embodiment of the present invention also provides a preparation method of a multifunctional specific bioadhesive hydrogel, such as figure 1 shown, including:

[0034] Step 1: Prepare an aqueous solution of acrylic acid A, an aqueous solution of acryloyl glycinamide B and an aqueous solution of polyphenolic compounds C;

[0035] Step 2: Stir and mix the acrylic acid aqueous solution A and the acryloylglycylamide aqueous solution B at room temperature, remove oxygen, add an initiator and a catalyst, and polymerize under nitrogen protection to obtain an acrylic acid-acryloylglycylamide copolymer pregel; and

[0036] Step 3: adding the polyphenolic compound aqueous solution C into the acrylic acid-acrylglycylglycylamide copolymer pregel, shearing and stirring to obtain the multifunctional specific bioadhesive hydrogel.

[0037] In the above step 1, the preparation of the acrylic acid aqu...

Embodiment 1

[0043] Example 1: Preparation method of bioadhesive hydrogel

[0044] (1) Dissolve 0.6 gram, 0.7 gram and 0.8 gram of acrylic acid (AA) in 5 milliliters of water respectively to obtain solution A with a concentration of 12wt.% 1 , 14wt.% solution A 2 , 16wt.% solution A 3 . 0.4 g, 0.3 g, and 0.2 g of acryloyl glycinamide (NAGA) were dissolved in 5 ml of water respectively to obtain a solution B with a concentration of 8 wt.%. 1 , 6wt.% solution B 2 , 4wt.% solution B 3 .

[0045] (2) the solution A 1 and solution B 1 , solution A 2 and solution B 2 , solution A3 and solution B 3 After stirring and mixing at room temperature, nitrogen was bubbled for 30 minutes to remove oxygen, 0.02 g of ammonium persulfate (APS) and 0.01 g of tetramethylethylenediamine (TEMED) were added, and polymerized at 60 ° C for 2 hours under nitrogen protection to obtain acrylic acid and acryloyl Pregelatin PAA6-NAGA4, PAA7-NAGA3, PAA8-NAGA2 with glycinamide monomer ratios of 6:4, 7:3 and 8:...

Embodiment 2

[0047] Example 2: Preparation method of multifunctional specific bioadhesive hydrogel and testing of tensile strength and adhesive strength using the hydrogel

[0048] (1) Dissolve 0.6 g of acrylic acid (AA) in 5 ml of water to obtain solution A; dissolve 0.4 g of acryloyl glycinamide (NAGA) in 5 ml of water to obtain solution B. 0.25 g, 0.5 g, and 0.75 g of tannic acid were respectively dissolved in 1 ml of water to obtain solution C.

[0049] (2) After stirring and mixing solution A and solution B at room temperature, nitrogen gas was bubbled for 30 minutes to remove oxygen, and 0.02 g of ammonium persulfate (APS) and 0.01 g of tetramethylethylenediamine (TEMED) were added. Polymerize for 2 hours to obtain pregel PAA6-NAGA4 with a monomer ratio of acrylic acid to acrylglycylglycylamide of 6:4.

[0050] (3) Add solution C to the PAA6-NAGA4 pre-gel prepared in step (2), shear and stir for 10 minutes to obtain PAA6-NAGA4-0.25TA, PAA6 with tannic acid content of 0.25 grams, 0.5...

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Abstract

The invention relates to a multifunctional specific biological bondinghydrogel withshearing ratesensibility, a preparation method and application thereof in infected wound dressing. The multifunctional specific biological bonding hydrogel is prepared from an acrylic acid-acryloyl glycinamide copolymer and a polyhydric phenol compound, wherein the acrylic acid-acryloyl glycinamide copolymer is formed by copolymerization of an acrylic acid monomer and an acryloyl glycinamide monomer, and the polyhydric phenolcompound is crosslinked with the acrylic acid-acryloyl glycinamide copolymer through hydrogen bond interaction to form the multifunctional specific biological bondinghydrogel. The preparation method comprises the following steps: adding thepolyhydric phenol compound into theacrylic acid-acryloyl glycinamide copolymer; carrying out multiple hydrogen bond cross-linking among carboxyl of acrylic acid, phenolic hydroxyl of the polyhydric phenol compound, carboxyl of acryloyl glycinamideand amino of acryloyl glycinamide, and adjusting the hydrogen bond densityby changing the copolymerization ratio and the addition amount of the polyhydric phenol compound, so that the multifunctionalspecific biological bonding hydrogel which is high in strength, capable of specifically adhering to tissues and easy to replace can be obtained.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a shear rate-sensitive multifunctional and specific bioadhesive hydrogel, a preparation method and its application in infected wound dressings. Background technique [0002] Wound dressings are essential for skin wounds caused by trauma, surgery, etc. Traditional wound dressings tend to adhere to skin wound tissue, making it difficult to change dressings, and increasing pain is not conducive to wound healing. In recent years, viscous hydrogel-based wound dressings have attracted extensive attention in the field of wound dressings due to their good biocompatibility and high water content. For example, using polyacrylic acid cross-linked with double-bonded gelatin as the main network, and introducing NHS functional groups and gelatin to prepare the hydrogel dressing can quickly absorb water, and then firmly adhere to biological tissues (skin, liver, kidney, etc.) ( N...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L33/02C08K5/1545C08K5/18C08F220/06C08F220/60A61L26/00
CPCA61L26/0014A61L26/008C08F220/06C08J3/075C08J2333/02C08K5/1545C08K5/18C08L33/02
Inventor 黄建永袁作楹苏醒
Owner PEKING UNIV
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