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Combined preparation containing flavone and immunomodulatory peptides, and preparation method and application thereof

An immunomodulatory, flavonoid-containing technology, which is applied in the field of biological nutrition and health care products and pharmaceutical preparations, can solve the problems of ineffective components, short gastric residence time, and poor absorption effect, so as to improve stability and bioavailability degree, improve water solubility and poor stability, and enhance the effect of bioavailability

Active Publication Date: 2020-06-23
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the practical application of flavonoids, there are many problems: (1) most flavonoids are insoluble in water and have poor stability in body fluids, making it difficult to apply to parenteral administration; (2) gastric residence time Short, poor penetration, poor absorption, low bioavailability in vivo, which greatly limits its benefits to human health; (3) A single effective component cannot achieve the expected efficacy
However, the above-mentioned prior art still has many limitations, and fails to comprehensively improve the existing problems in the application of flavonoids, and the technical process provided is also relatively complicated, making it difficult to promote and apply industrially.

Method used

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  • Combined preparation containing flavone and immunomodulatory peptides, and preparation method and application thereof
  • Combined preparation containing flavone and immunomodulatory peptides, and preparation method and application thereof
  • Combined preparation containing flavone and immunomodulatory peptides, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] (1) configuring potassium carbonate solution of chrysin (molar concentration is 35mM); (2) configuring molar concentration of 200mM ferric chloride aqueous solution; (3) configuring molar concentration of 10mM immunomodulatory peptide (SEQ ID NO 2: RKDVY ) aqueous solution;

[0077] (4) According to the molar concentration ratio of chrysin:ferric chloride:immunomodulatory peptide is 5:1:1, add it into pure water, the total mass fraction of the final system is 5%; adjust the pH value of the mixed solution to 7.4 , to obtain a blue-brown combined preparation solution. The resulting combined preparation solution was dialyzed and then freeze-dried to obtain a blue-brown powder.

Embodiment 2

[0079] (1) Sodium hydroxide solution (molar concentration is 35mM) of configuring luteolin; (2) Ferric chloride aqueous solution whose molar concentration is 200mM is configured; (3) Immunomodulatory peptide (SEQ ID NO 1 : PGPIPN) aqueous solution;

[0080] (4) According to the molar concentration ratio of luteolin:ferric chloride:immunomodulatory peptide is 2:4:1, add it into pure water, the total mass fraction of the final system is 2%; adjust the pH value of the mixed solution to 7.4, to obtain a brown-black combination preparation solution. The transmission electron micrograph and the solution photo of the resulting combined preparation are as follows: figure 1 , the results showed that the prepared combination formulations were uniform in size and had good dispersibility. Measure the absorption spectrum of combination preparation with ultraviolet spectrophotometer, the result is as follows: figure 2

[0081] The resulting combined preparation solution was dialyzed an...

Embodiment 3

[0083](1) configure the sodium hydroxide solution (molar concentration is 70mM) of nobietin; (2) configure the molar concentration of 10mM ferrous chloride aqueous solution; (3) configure the molar concentration of 1mM immunomodulatory peptide (SEQ ID NO 5 : LLY) aqueous solution;

[0084] (4) According to the molar concentration ratio of nobietin: ferrous chloride: immunomodulatory peptide is 5:1:1, add it into pure water, the total mass fraction of the final system is 0.1%; adjust the pH value of the mixed solution to 6.5, to obtain a brown combination preparation solution.

[0085] The scanning electron micrograph of gained combination preparation and solution photo are as follows image 3 , the results showed that the prepared combination preparation was granular and uniform in size, and the particle size was consistent with the DLS results.

[0086] The resulting combined preparation solution was dialyzed and then freeze-dried to obtain a brown powder.

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Abstract

The invention relates to a combined preparation containing flavone and immunomodulatory peptides, and a preparation method and application thereof. The combined preparation contains the following components: (1) a natural flavonoid compound; (2) metal ions; and (3) immunomodulatory peptides. The combined preparation can improve the stability and bioavailability of the natural flavonoid compound and immunomodulatory peptides, and when applied to mammals, the combined preparation can synergistically enhance immune response and play a role in improving the immunity of the organism. The combined preparation is applied to low-immunity people and prevention and control of viral and bacterial infectious diseases, accords with the national guidance direction of the large health industry, and has positive significance and broad prospects for strategic measures of preventive treatment of diseases.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations and the technical field of biological nutrition and health products, in particular to a combined preparation containing flavonoids and immunomodulatory peptides, its preparation method and application. Background technique [0002] Modern evidence-based medical research shows that the underlying logic of body health is human immunity, which is also the contemporary interpretation of "supervised medical treatment to prevent disease". With the enhancement of health awareness in recent years, there is a broad market demand for combination preparations that can maintain or promote health, prevent or alleviate diseases. The upsurge in this area has made the use of traditional Chinese medicine for health care and disease prevention and control re-emphasized. [0003] Flavonoids (flavonoids) generally refer to a series of compounds derived from 2-phenylchromone (two benzene rings connected to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/352A61K38/22A61K38/05A61K38/06A61K38/07A61K38/08A61K33/30A61K33/26A61K33/34A61K33/06A61K33/24A61K33/32A61K33/04A61P37/04A61P39/00A23L33/105A23L33/17A23L33/16
CPCA61K45/06A61K31/352A61K38/2292A61K38/2271A61K38/05A61K38/06A61K38/07A61K38/08A61K33/30A61K33/26A61K33/34A61K33/06A61K33/24A61K33/32A61K33/04A61P37/04A61P39/00A23L33/105A23L33/17A23L33/16A23V2002/00A61K2300/00A23V2200/324
Inventor 闫学海沈桂芝邹千里邢蕊蕊袁成前
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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