Antibacterial and hemostatic multifunctional composite hydrogel dressing and preparation method thereof

A composite hydrogel and hydrogel technology, applied in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve the problems of poor hemostatic effect and low strength of hemostatic gel, and achieve inhibition of wound infection, excellent antibacterial properties, high The effect of water absorption

Active Publication Date: 2020-07-10
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem solved by the present invention: the tr

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  • Antibacterial and hemostatic multifunctional composite hydrogel dressing and preparation method thereof
  • Antibacterial and hemostatic multifunctional composite hydrogel dressing and preparation method thereof
  • Antibacterial and hemostatic multifunctional composite hydrogel dressing and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0031] The preparation method of the antibacterial and hemostatic multifunctional composite hydrogel dressing includes the following steps:

[0032] Step 1): Preparation of component A hydrogel: carboxylic acid with active double bond or sodium carboxylate, amide with active double bond and aldehyde with active double bond are dissolved in deionized water and Stir and mix thoroughly, slowly add 10-30% NaOH aqueous solution to it for neutralization, and control the temperature of the reaction system to be lower than 30°C to prevent carboxylic acids or sodium carboxylates with active double bonds; after neutralization is complete , Add a double bond crosslinking agent to the reaction system, and add persulfate to initiate polymerization. The resulting hydrogel is swelled in distilled water, and the water is changed many times to remove unreacted monomers, crosslinking agent and initiator; take out the water The gel is freeze-dried to obtain the A component hydrogel;

[0033] Step 2)...

Example Embodiment

[0040] Example 1

[0041] Preparation of component A hydrogel: according to mass parts, the raw material components include: 100 parts of acrylic acid, 100 parts of acrylamide, 30 parts of citronellal, 10000 parts of deionized water, 100 parts of NaOH aqueous solution with a mass concentration of 20%, 1 part of double bond crosslinking agent, 1 part of persulfate. Acrylic acid, acrylamide and citronellal are dissolved in deionized water and fully stirred and mixed. Slowly add a 20% mass concentration NaOH aqueous solution to neutralize (control the temperature of the reaction system to be lower than 30°C to prevent acrylic acid from self-polymerization). After neutralization is completed , Add N,N'-methylenebisacrylamide to the reaction system, and add ammonium persulfate to initiate polymerization. The resulting hydrogel is swelled in distilled water, and the water is changed many times to remove unreacted monomers and crosslinking agents. With initiator. The hydrogel was take...

Example Embodiment

[0044] Example 2

[0045] Preparation of component A hydrogel: according to mass parts, the raw material components include: 100 parts of methacrylic acid, 100 parts of acrylamide, 30 parts of citronellal, 10000 parts of deionized water, 100 parts of NaOH aqueous solution with a mass concentration of 20% Parts, 1 part of double bond crosslinking agent, 1 part of persulfate. Methacrylic acid, acrylamide and citronellal are dissolved in deionized water and fully stirred and mixed. Slowly add 20% by mass NaOH aqueous solution to neutralize (control the temperature of the reaction system to be lower than 30°C to prevent acrylic acid from self-polymerization), neutralize After completion, add N,N'-methylenebisacrylamide to the reaction system, and add ammonium persulfate to initiate polymerization. The resulting hydrogel is swelled in distilled water, and the water is changed many times to remove unreacted monomers and Coupling agent and initiator. The hydrogel was taken out and lyo...

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Abstract

The invention discloses an antibacterial and hemostatic multifunctional composite hydrogel dressing and a preparation method thereof. The hydrogel dressing comprises a component A hydrogel and a component B hydrogel, wherein the component A hydrogel comprises a carboxylic acid or carboxylic acid sodium salt, an amide, an aldehyde, a NaOH aqueous solution, and the like; and the component B hydrogelcomprises dopamine hydrochloride, a carboxylic acid or anhydride, a modified guanidine salt, mesoporous silica, a modified diamine, and the like. The preparation method is as follows: separately preparing the component A hydrogel and the component B hydrogel, and then compounding the component A hydrogel and the component B hydrogel. The component A achieves hemostatic effects by rapid swelling and absorption of large amounts of water in the blood; and the component B achieves hemostatic effects by quickly sealing damaged blood vessels. The hemostatic hydrogel dressing of the invention solvesthe problem that a single hydrogel cannot have high strength, strong adhesion and high water absorption performance at the same time, and realizes rapid hemostasis. At the same time, the hydrogel dressing has excellent antibacterial properties and can effectively inhibit wound infection.

Description

technical field [0001] The invention discloses a safe and efficient hemostatic antibacterial multifunctional composite hydrogel dressing and a preparation method thereof, belonging to the technical field of medical hydrogel materials. Background technique [0002] Damaged blood vessels, extensive bleeding and oozing during surgery and trauma operations pose great dangers to human life. The body's physiological hemostasis alone is far from achieving rapid and effective hemostasis. Therefore, it is necessary to introduce exogenous substances to accelerate wound hemostasis. . Hemostatic materials have always been a research hotspot in the field of biomaterials, especially absorbable hemostatic materials. At present, the main absorbable hemostatic materials at home and abroad include fibrin glue, gelatin, collagen, oxidized cellulose, chitosan and calcium alginate, etc. The hemostatic effect of these products can meet the needs of rapid hemostasis in general wounds, but for wou...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08F220/06C08F220/56C08F216/34C08F222/38C08F226/02C08J3/075
CPCA61L26/0014A61L26/0052A61L26/0061A61L26/0066A61L26/008A61L2300/216A61L2300/404A61L2300/45A61L2400/04C08F220/06C08F220/56C08F222/38C08J3/075C08L33/26C08L35/00C08F216/34C08F222/385C08F226/02
Inventor 吴德群刘畅韩华叶婷婷王学利李发学俞建勇
Owner DONGHUA UNIV
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