Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antibacterial and hemostatic multifunctional composite hydrogel dressing and preparation method thereof

A composite hydrogel and hydrogel technology, applied in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve the problems of poor hemostatic effect and low strength of hemostatic gel, and achieve inhibition of wound infection, excellent antibacterial properties, high The effect of water absorption

Active Publication Date: 2020-07-10
DONGHUA UNIV
View PDF11 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem solved by the present invention: the traditional hemostatic gel has low strength and poor hemostatic effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antibacterial and hemostatic multifunctional composite hydrogel dressing and preparation method thereof
  • Antibacterial and hemostatic multifunctional composite hydrogel dressing and preparation method thereof
  • Antibacterial and hemostatic multifunctional composite hydrogel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] The preparation method of the above-mentioned antibacterial and hemostatic multifunctional composite hydrogel dressing comprises the following steps:

[0032] Step 1): the preparation of component A hydrogel: dissolve carboxylic acid or sodium carboxylic acid salt with active double bond, amide with active double bond and aldehyde with active double bond in deionized water and Stir and mix well, slowly add NaOH aqueous solution with a mass concentration of 10-30% for neutralization, and control the temperature of the reaction system below 30°C to prevent carboxylic acids or sodium carboxylic acid salts with active double bonds; after neutralization , add a double bond cross-linking agent to the reaction system, and add persulfate to initiate polymerization, the obtained hydrogel swells in distilled water, change the water several times, remove unreacted monomers, cross-linking agents and initiators; take out the water The gel is freeze-dried to obtain component A hydrog...

Embodiment 1

[0041] Preparation of component A hydrogel: in parts by mass, the raw material components include: 100 parts of acrylic acid, 100 parts of acrylamide, 30 parts of citronellal, 10000 parts of deionized water, 100 parts of NaOH aqueous solution with a mass concentration of 20%, 1 part of double bond crosslinking agent, 1 part of persulfate. Dissolve acrylic acid, acrylamide and citronellal in deionized water and fully stir and mix, slowly add NaOH aqueous solution with a mass concentration of 20% to neutralize (control the temperature of the reaction system below 30°C to prevent self-polymerization of acrylic acid), after neutralization , add N,N'-methylenebisacrylamide to the reaction system, and add ammonium persulfate to initiate polymerization, the obtained hydrogel is swollen in distilled water, and the water is changed several times to remove unreacted monomers and crosslinking agents with initiator. The hydrogel was taken out and subjected to freeze-drying treatment to o...

Embodiment 2

[0045] Preparation of component A hydrogel: in parts by mass, the raw material components include: 100 parts of methacrylic acid, 100 parts of acrylamide, 30 parts of citronellal, 10000 parts of deionized water, and 100 parts of NaOH aqueous solution with a mass concentration of 20%. 1 part, 1 part of double bond crosslinking agent, 1 part of persulfate. Dissolve methacrylic acid, acrylamide and citronellal in deionized water and fully stir and mix, slowly add NaOH aqueous solution with a mass concentration of 20% for neutralization (control the temperature of the reaction system below 30°C to prevent self-polymerization of acrylic acid), neutralize After completion, N,N'-methylenebisacrylamide was added to the reaction system, and ammonium persulfate was added to initiate polymerization. The obtained hydrogel was swollen in distilled water, and the water was changed several times to remove unreacted monomers and cross-linked gels. Liaisons and initiators. The hydrogel was ta...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Adhesionaaaaaaaaaa
Login to View More

Abstract

The invention discloses an antibacterial and hemostatic multifunctional composite hydrogel dressing and a preparation method thereof. The hydrogel dressing comprises a component A hydrogel and a component B hydrogel, wherein the component A hydrogel comprises a carboxylic acid or carboxylic acid sodium salt, an amide, an aldehyde, a NaOH aqueous solution, and the like; and the component B hydrogelcomprises dopamine hydrochloride, a carboxylic acid or anhydride, a modified guanidine salt, mesoporous silica, a modified diamine, and the like. The preparation method is as follows: separately preparing the component A hydrogel and the component B hydrogel, and then compounding the component A hydrogel and the component B hydrogel. The component A achieves hemostatic effects by rapid swelling and absorption of large amounts of water in the blood; and the component B achieves hemostatic effects by quickly sealing damaged blood vessels. The hemostatic hydrogel dressing of the invention solvesthe problem that a single hydrogel cannot have high strength, strong adhesion and high water absorption performance at the same time, and realizes rapid hemostasis. At the same time, the hydrogel dressing has excellent antibacterial properties and can effectively inhibit wound infection.

Description

technical field [0001] The invention discloses a safe and efficient hemostatic antibacterial multifunctional composite hydrogel dressing and a preparation method thereof, belonging to the technical field of medical hydrogel materials. Background technique [0002] Damaged blood vessels, extensive bleeding and oozing during surgery and trauma operations pose great dangers to human life. The body's physiological hemostasis alone is far from achieving rapid and effective hemostasis. Therefore, it is necessary to introduce exogenous substances to accelerate wound hemostasis. . Hemostatic materials have always been a research hotspot in the field of biomaterials, especially absorbable hemostatic materials. At present, the main absorbable hemostatic materials at home and abroad include fibrin glue, gelatin, collagen, oxidized cellulose, chitosan and calcium alginate, etc. The hemostatic effect of these products can meet the needs of rapid hemostasis in general wounds, but for wou...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L26/00C08F220/06C08F220/56C08F216/34C08F222/38C08F226/02C08J3/075
CPCA61L26/0014A61L26/0052A61L26/0061A61L26/0066A61L26/008A61L2300/216A61L2300/404A61L2300/45A61L2400/04C08F220/06C08F220/56C08F222/38C08J3/075C08L33/26C08L35/00C08F216/34C08F222/385C08F226/02
Inventor 吴德群刘畅韩华叶婷婷王学利李发学俞建勇
Owner DONGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com