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A kind of polymer biomimetic coating and preparation method thereof

A polymer and coating technology, applied in the medical field, can solve the problems of poor blood compatibility, single drug coating design, no change design coating, etc., to achieve inhibition of inflammation and thrombus, excellent anticoagulation Ability, the effect of high BCI index

Active Publication Date: 2021-01-08
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, follow-up studies found that the rate of myocardial infarction and cardiovascular mortality increased after implantation of such DES
This is mainly because: firstly, the drug coating has a single design, and the coating is not designed according to the change of the blood microenvironment, and the balance of the blood microenvironment cannot be adjusted in the end; secondly, the drug release usually degrades the surface structure of the coating, making the blood of the device Compatibility deteriorates, which can easily cause platelet aggregation and acute thrombosis; finally, the coating design ignores the impact of inflammation on the device, and inflammation is the main cause of post-implantation and late-stage thrombosis

Method used

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  • A kind of polymer biomimetic coating and preparation method thereof
  • A kind of polymer biomimetic coating and preparation method thereof
  • A kind of polymer biomimetic coating and preparation method thereof

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preparation example Construction

[0048] The present invention also provides a kind of preparation method of polymer biomimetic coating, comprises the following steps:

[0049] A) Using electrospinning technology or electrostatic spraying technology, the inner layer mixed solution is evenly attached to the surface of the substrate, and the inner layer is obtained after vacuum drying; the inner layer mixed solution includes biocompatible polymers, anti-inflammatory drugs and the first a solvent;

[0050] B) Using electrospinning technology or electrostatic spraying technology, the outer layer mixed solution is evenly attached to the surface of the inner layer, and after vacuum drying, a polymer biomimetic coating is obtained; the outer layer mixed solution includes an inflammation-responsive polymer and second solvent.

[0051] In the preparation method of the polymer biomimetic coating provided by the present invention, the raw materials and components used are the same as above, and will not be repeated here...

Embodiment 1

[0075] Example 1: Metal Substrate

[0076]Using titanium metal alloy (TA1ELI, Tongxiang Metal Materials Co., Ltd.) as the substrate, the titanium metal alloy is fixed on the spinning or spraying receiver for surface coating. 0.3g indomethacin and 1.7g heparin sodium (50000Da) were dissolved in 15g acetic acid and water (2:1, mass ratio) mixed solvent, the mass concentration of indomethacin and heparin sodium was 12%. The mixed solution is then transferred to the injection needle, and is spun or sprayed at an injection speed of 1 mL / h under a potential difference of 22 kv. Receive at 15cm for 2h, dry at 37°C for 48h, and the thickness of the inner layer is 1500μm. Then prepare the outer layer solution. Dissolve 5 g of 0.15 g of 4-methyl-1-(pinacol p-phenylboronic acid)methoxy-2,6-dimethanol (the degree of polymerization is 2000) in dichloromethane solution (mass concentration is 3%) Inject at a rate of 1mL / h under a potential difference of 10kv, receive at a distance of 15cm...

Embodiment 2

[0078] Platelet adhesion assay:

[0079] Fresh blood was drawn from the ear artery of healthy adult New Zealand rabbits (2.5±0.5kg, provided by the Animal Experiment Center of Jilin University), and the blood was collected in blood collection tubes filled with 2mL of 3.5% sodium citrate to prevent coagulation. Blood was centrifuged at two different rotational speeds in order to obtain two different types of plasma. The first type (platelet rich plasma (PRP)) was obtained by centrifugation at 1000 rpm and the second type (platelet poor plasma (PPP)) by centrifugation at 1500 rpm. Plasma was diluted in PBS (Phosphate Buffered Saline) in order to carry out experiments in sufficient quantities. The adsorption of platelets was visually observed by scanning electron microscope.

[0080] The polymer biomimetic coating (2 * 2cm) that prepares described in embodiment 1 2 ) and polycaprolactone spinning coating (2 × 2cm 2 ) were respectively immersed in PRP at 37°C and under continu...

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Abstract

The invention relates to the field of medical technology, in particular to a polymer biomimetic coating and a preparation method thereof. The polymer biomimetic coating comprises: a substrate; an inner layer attached to the substrate, the inner layer comprising a biocompatible polymer and an anti-inflammatory drug; an outer layer attached to the inner layer, The outer layer includes an inflammation responsive polymer. During the process of implanting medical devices modified by the polymer biomimetic coating of the present invention into blood vessels, acute inflammation is caused, and the outer inflammation-responsive polymer absorbs excessive ROS, degrades, and eliminates acute inflammation. After the outer layer is degraded, the inner layer is exposed, and the inner layer contains anti-inflammatory drugs that are slowly released in the blood environment to achieve the effect of anti-chronic inflammation and improve the safety and service life of implanted medical devices. The polymer biomimetic coating of the invention has the ability of anti-platelet adhesion, has a higher BCI index, has excellent anti-coagulant ability, and can effectively inhibit the occurrence of inflammation and thrombus.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a polymer biomimetic coating and a preparation method thereof. Background technique [0002] Cardiovascular diseases have become the number one cause of human death. Cardiovascular implant interventional medical devices, such as heart stents, artificial blood vessels, heart valves, etc., are one of the important means of cardiovascular treatment. This kind of medical device is likely to form thrombus on the surface of the medical device when it comes into contact with blood, resulting in the failure of the medical device. Through surface modification, the thrombus caused by the initial contact between blood and medical devices can generally be inhibited. However, since the implanted device is in the blood environment for a long time, changes in the blood microenvironment will cause late and late thrombus, which also threatens the health of patients. The formation of thrombus i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/16A61L31/14
CPCA61L31/10A61L31/14A61L31/16A61L2300/41A61L2300/42A61L2300/604A61L2300/606C08L67/04C08L5/10
Inventor 石强项泽鸿陈润海马志方王皓正
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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