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A degradable, anti-adhesion double-layer dura mater patch and its preparation method

A dura mater and anti-adhesion technology, applied in prostheses, products, educts, etc., can solve the problems of immune rejection, loss of effective active ingredients, limited dura mater regeneration ability, etc., and achieve the effect of a simple preparation method

Active Publication Date: 2021-12-07
江西光至金辉医疗制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex process of decellularization, degreasing, and antigen removal of animal-derived tissues, the treatment reagents may cause damage to the natural structure, loss of effective active ingredients or residual treatment reagents, resulting in tissue adhesion after material implantation, reduced tissue repair effect, and occurrence of The risk of immune rejection; the cost of artificial synthetic materials is high, because the materials lack biological activity and the degradation products are acidic, foreign body rejection is prone to occur after implantation, and the ability to promote dura mater regeneration is limited, which may easily cause incomplete dura mater closure and cerebrospinal fluid leak

Method used

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  • A degradable, anti-adhesion double-layer dura mater patch and its preparation method
  • A degradable, anti-adhesion double-layer dura mater patch and its preparation method
  • A degradable, anti-adhesion double-layer dura mater patch and its preparation method

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Embodiment 1

[0064] A method for preparing a degradable, anti-adhesion double-layer dura mater patch, comprising the following steps:

[0065] 1) Preparation of dense layer by horizontal casting method

[0066] High molecular weight chitosan powder (deacetylation degree is 85%, viscosity-average molecular weight is 0.85×10 6 ) into 2% (v / v) acetic acid solution, stirring and dissolving at room temperature to obtain 1.5wt.% chitosan acetic acid solution. Add bacterial cellulose dispersion in a preferred ratio, stir evenly and filter to remove undissolved impurities, vacuum defoam until no bubbles are generated within 2 minutes, and obtain a 0.5wt.% chitosan / bacterial cellulose mixed solution. The above mixed solution was poured into a high borosilicate petri dish with a diameter of 90mm, and dried overnight in a blast oven at 60°C. After returning to normal temperature, pour 1mol / L sodium hydroxide solution to release the mold and neutralize excess acetic acid, then wash the film with pur...

Embodiment 2

[0077] A method for preparing a degradable, anti-adhesion double-layer dura mater patch, comprising the following steps:

[0078] 1) Preparation of dense layer by horizontal casting method

[0079] High molecular weight chitosan powder (deacetylation degree is 85%, viscosity-average molecular weight is 0.85×10 6 ) into 2% (v / v) acetic acid solution, stirring and dissolving at room temperature to obtain 1.5wt.% chitosan acetic acid solution. Add bacterial cellulose dispersion in a preferred ratio, stir evenly and filter to remove undissolved impurities, vacuum defoam until no bubbles are generated within 2 minutes, and obtain a 0.5wt.% chitosan / bacterial cellulose mixed solution. The above mixed solution was poured into a high borosilicate petri dish with a diameter of 90mm, and dried overnight in a blast oven at 60°C. After returning to normal temperature, pour 1mol / L sodium hydroxide solution to release the mold and neutralize excess acetic acid, then wash the film with pur...

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Abstract

A degradable, anti-adhesion double-layer dura mater patch and a preparation method thereof, the double-layer dura mater patch includes a dense layer and a porous layer; the dense layer faces the brain tissue side when the patch is used, It is used to prevent cerebrospinal fluid leakage, prevent brain tissue adhesion, and can be sutured; the porous layer faces the side of the skull when the patch is used, and is used to support the growth, migration, proliferation and differentiation of autologous dura mater cells, and promote autologous dura mater cells. The meninges are regenerated, and after hydrogelation, a tissue adhesive effect is produced to improve the sealing density. The dura mater patch has good flexibility, good mechanical properties and tissue compatibility, can significantly promote the regeneration of damaged meningeal tissue, has anti-adhesion and biodegradable properties, is easy to store, disinfect and prepare before surgery, and fully utilizes biological polysaccharides. The advantages of the material in tissue repair are extremely valuable.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a degradable and anti-adhesion double-layer dura mater patch and a preparation method thereof. Background technique [0002] The dura mater is located under the skull, covering the brain tissue and the spine. It is a thick and tough double-layer membrane, which is the ultimate barrier to prevent the leakage of cerebrospinal fluid and maintain the stability of the cranial nerves. Trauma, craniocerebral surgery and postoperative complications will cause dura mater tear or injury, timely and effective repair of defective dura mater tissue will accelerate tissue healing and avoid intracranial infection, cerebrospinal fluid leakage, encephalocele, and brain tissue adhesion , epilepsy and other complications, reducing hospitalization time and costs. The artificial meningeal patch is used to cover the meningeal defect, keep the brain stable, induce the surrounding normal meningeal c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/20A61L27/50A61L27/56A61L27/58C08J5/18C08J9/28C08J3/24C08L5/08C08L1/02
CPCA61L27/20A61L27/50A61L27/56A61L27/58A61L2430/32C08J3/246C08J5/18C08J9/28C08J2201/0484C08J2301/02C08J2305/08C08J2401/02C08J2405/08C08L5/08C08L1/02Y02P20/141
Inventor 吴奕光邓文婧
Owner 江西光至金辉医疗制品有限公司
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