Medical antibacterial wound-protecting hydrogel dressing and preparation method thereof

A technology of hydrogel and purified water, applied in medical science, bandages, etc., can solve the problems of easy preparation, economical antibacterial hemostasis, wound repair effect, etc. stimulating effect

Inactive Publication Date: 2020-08-04
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But prior art also does not utilize chitosan derivative, matrigel as the dressing prepared by basic component, can not realize

Method used

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  • Medical antibacterial wound-protecting hydrogel dressing and preparation method thereof
  • Medical antibacterial wound-protecting hydrogel dressing and preparation method thereof
  • Medical antibacterial wound-protecting hydrogel dressing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] A medical antibacterial and wound-protecting hydrogel dressing, whose ingredients include: 0.5 g of water-soluble chitosan derivatives, 100 mL of purified water, acrylamide, extracellular matrix, cross-linking agent, initiator, and accelerator.

[0027] In this embodiment, the extracellular matrix is ​​liquid Matrigel.

[0028] In this embodiment, the water-soluble chitosan derivative is quaternized chitosan, carboxymethyl chitosan or hydroxypropyl chitosan.

[0029] In this embodiment, the crosslinking agent is N,N'-methylenebisacrylamide, N,N'-diallyl tartaric acid diamide or divinylbenzene.

[0030] In the present embodiment, described initiator is ammonium persulfate, sodium persulfate or potassium persulfate, and described accelerator is TEMED.

[0031] A preparation method of a medical antibacterial wound-protecting hydrogel dressing, comprising the following steps:

[0032] (1) First, dissolve 0.5 g of water-soluble chitosan derivatives in 100 mL of purified wa...

Embodiment 2

[0037] A medical antibacterial and wound-protecting hydrogel dressing, its ingredients include: 1 g of water-soluble chitosan derivatives, 100 mL of purified water, acrylamide, extracellular matrix, cross-linking agent, initiator, and accelerator.

[0038] In this embodiment, the extracellular matrix is ​​liquid Matrigel.

[0039] In this embodiment, the water-soluble chitosan derivative is quaternized chitosan, carboxymethyl chitosan or hydroxypropyl chitosan.

[0040] In this embodiment, the crosslinking agent is N,N'-methylenebisacrylamide, N,N'-diallyl tartaric acid diamide or divinylbenzene.

[0041] In the present embodiment, described initiator is ammonium persulfate, sodium persulfate or potassium persulfate, and described accelerator is TEMED.

[0042] A preparation method of a medical antibacterial wound-protecting hydrogel dressing, comprising the following steps:

[0043] (1) First, dissolve 1 g of water-soluble chitosan derivatives in 100 mL of purified water to...

Embodiment 3

[0048] A medical antibacterial and wound-protecting hydrogel dressing, the ingredients of which include: 1.5 g of water-soluble chitosan derivatives, 100 mL of purified water, acrylamide, extracellular matrix, cross-linking agent, initiator, and accelerator.

[0049] In this embodiment, the extracellular matrix is ​​liquid Matrigel.

[0050] In this embodiment, the water-soluble chitosan derivative is quaternized chitosan, carboxymethyl chitosan or hydroxypropyl chitosan.

[0051] In this embodiment, the crosslinking agent is N,N'-methylenebisacrylamide, N,N'-diallyl tartaric acid diamide or divinylbenzene.

[0052] In the present embodiment, described initiator is ammonium persulfate, sodium persulfate or potassium persulfate, and described accelerator is TEMED.

[0053] A preparation method of a medical antibacterial wound-protecting hydrogel dressing, comprising the following steps:

[0054] (1) First, dissolve 1.5g of water-soluble chitosan derivatives in 100mL of purifi...

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Abstract

The invention discloses an antibacterial wound-protecting hydrogel dressing and a preparation method thereof. The antibacterial wound-protecting hydrogel dressing comprises the following main components: a water-soluble chitosan derivative, matrix glue and a water-soluble high-molecular polymer. The preparation method comprises the following steps: preparing a chitosan derivative from purified water, fully and uniformly mixing the components, adding the chitosan derivative into a mold, adding a liquid matrix gel and an acrylamide solution, sequentially adding a crosslinking agent, an initiatorand an accelerator to form gel, and rinsing the gel with deionized water to remove the redundant crosslinking agent, thereby obtaining the hydrogel dressing. The dressing can absorb wound exudate andsecreta. The chitosan derivative has polycation, so that when being combined with negatively charged protein, teichoic acid and the like on the surface of thallus, the chitosan has strong antibacterial activity, and has unique advantages in prevention and treatment of wound infection. Matrix glue is one of extracellular matrixes, contains various bioactive components and plays an important role in the wound healing process. The hydrogel dressing can be applied to protection and repair of various types of wounds such as burns, wounds, pressure sores and the like.

Description

technical field [0001] The invention relates to the technical field of biomedicine preparation, in particular to a medical antibacterial wound-protecting hydrogel dressing and a preparation method thereof. Background technique [0002] Wound repair has always been a common problem faced by orthopedics, plastic surgery, hand surgery and other departments. There are many repair methods for skin and soft tissue wounds, including skin grafting, skin flap or skin stretch closure. In addition, the use of tissue engineering to solve the problem of wound repair has become more and more widespread, and some repair effects can reach a very good level. The representative types include hydrogel, artificial dermis, and acellular matrix. Construct a microenvironment conducive to wound repair, promote the proliferation, migration, and differentiation of related repair cells, and thus close the wound. However, some synthesis methods are complicated and the raw materials are expensive, whi...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0066A61L26/008A61L26/0085A61L2300/232A61L2300/404A61L2300/412C08L5/08C08L33/26
Inventor 刘国辉薛航周武李卉米博斌刘毅刘静熊元胡良聪刘梦非
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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