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Soluble micro-needle and preparation method thereof

A soluble and microneedle technology, applied in the field of nano-microneedles, can solve the problems of expensive equipment, inability to meet mass production, and large skin damage

Active Publication Date: 2020-09-01
YANTAI MAGIC NANOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Traditionally, the preparation of microneedle templates by the microtemplate method is mainly prepared by ion etching and laser etching. The disadvantages are that the etching accuracy is not high, and the equipment is expensive and the etching speed is low, which cannot meet the mass production.
Therefore, the precision and density of microneedles prepared by forming microneedles to prepare PDMS reverse molds are low, causing great damage to the skin, and there is a risk of the needle body breaking into the body, and there are great restrictions on the degree of freedom of shape, single dose and price. limit

Method used

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  • Soluble micro-needle and preparation method thereof
  • Soluble micro-needle and preparation method thereof
  • Soluble micro-needle and preparation method thereof

Examples

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preparation example Construction

[0043] This application also provides a method for preparing soluble microneedles, including the following steps:

[0044] Mixing the soluble polymer material and the soluble active material to obtain a mixed solution;

[0045] Add the mixed solution to the female microneedle mold, then vacuum defoam, then solidify and demold to obtain soluble microneedles;

[0046] The microneedle female mold is a microporous polydimethylsiloxane mold obtained from a microneedle male mold inverted mold, and the microneedle male mold is a series of microneedles arranged in any shape prepared by laser direct writing technology .

[0047] In the process of preparing soluble microneedles, this application first prepares the microneedle male mold, which is prepared by laser direct writing technology, specifically:

[0048] Construct a model of the microneedle to be printed, and import the model into the lithography machine in a format that can be recognized by the lithography machine;

[0049] The printing ...

Embodiment 1

[0061] Example 1 Laser direct writing technology to prepare a microneedle male mold, specifically as follows figure 1 As shown, figure 1 In order to use laser direct writing technology to prepare a schematic diagram of the microneedle male mold, figure 1 1 is a glass slide, 2 is a photoresist, 3 is a nano microneedle, 4 is a focused laser, 5 is a lens, 6 is a galvanometer, and 7 is a printing platform. The specific steps are as follows:

[0062] 1) Construct a three-dimensional model of the outer contour of the microneedle to be printed, export the three-dimensional model into a format recognized by the control software of the three-dimensional lithography machine and import it into the lithography machine. The three-dimensional model includes a cone, a triangular pyramid, a polygonal pyramid, etc. ;

[0063] 2) Take a clean 76mm*26mm*1mm thick glass slide as the printing substrate slide 1, use compressed nitrogen to blow clean, immerse the slide 1 in the acetone solution and ultras...

Embodiment 2

[0067] Example 2 Preparation of soluble microneedles

[0068] 1) Preparation of microneedle preparation solution

[0069] Dissolve 0.5 g of vinylpyrrolidone in 2.5 g of deionized water, stir quickly, weigh 0.3 g of hyaluronic acid (molecular weight 7000), add in three times, stir until fully dissolved, weigh out 0.05 g of coenzyme Q10, stir evenly, and leave it overnight. Centrifuge to remove excess air bubbles and obtain microneedle preparation solution;

[0070] 2) Pour the microneedle production solution into the microneedle female mold prepared in Example 1, and then place the microneedle female mold in a vacuum drying oven at a temperature of 35°C, a vacuum of -0.1Mpa, and a vacuum for 30 minutes. After molding, place the microneedle female mold in a desiccator for 24 hours to fully dry;

[0071] 3) Preparation of microneedle bottom plate

[0072] Dissolve 0.3 g of copovidone, 0.3 g of polyvinyl alcohol, and 0.6 g of hydroxypropyl cellulose in 10 g of deionized water, stir to ful...

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Abstract

The invention provides a soluble micro-needle. The soluble micro-needle is prepared from a soluble polymer material and a soluble active material in a micro-needle female die, wherein the micro-needlefemale die is a microporous polydimethylsiloxane die obtained by inverting a micro-needle male die, and the micro-needle male die is a series of micro-needles, which are prepared by a laser direct writing technology and are arranged in any shape. The invention further provides a preparation method of the soluble micro-needle. The soluble micro-needle is prepared from a micro-needle female die, which is obtained by inverting a micro-needle male die prepared by a laser direct writing technology; and the micro-needle female die material has good flexibility and demoulding property and can be used for preparing micro-needles in any shape, so that the soluble micro-needle has the characteristics of large height-width ratio, controllable size, controllable dosage, high integration level, simplicity and rapidness in production, low cost, material saving and flexibility in processing.

Description

Technical field [0001] The invention relates to the technical field of nano microneedles, in particular to a soluble microneedle and a preparation method thereof. Background technique [0002] Nano-microneedle is an efficient new transdermal drug delivery technology, with a variety of micro-needle-like structures, and its length is generally 10-150μm. These micro-needles have a suitable length and sufficient mechanical strength to pierce the stratum corneum of the skin without damaging the nerve endings, breaking the blocking effect of the stratum corneum barrier on drugs, greatly improving the delivery efficiency of drugs, and making macromolecules and Transdermal delivery of hydrophilic drugs is possible. [0003] At present, nano-microneedles include solid microneedles, coated microneedles, hollow microneedles and soluble microneedles; among them, solid microneedles are usually used as pretreatment of the skin to create pores on the skin surface through which drugs can be deliv...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61M37/00A61K47/32A61K47/36A61K47/38A61K31/122A61K31/203A61K31/728A61K38/18A61P17/00A61P17/16A61P17/18
CPCA61K9/0021A61K47/36A61K47/32A61K47/38A61K31/203A61K31/122A61K38/1808A61K31/728A61M37/0015A61P17/16A61P17/00A61P17/18A61M2037/0046A61M2037/0053A61K2300/00
Inventor 史强胡海龙
Owner YANTAI MAGIC NANOTECHNOLOGY CO LTD
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