Guide wire coating composition, guide wire coating and preparation method of guide wire coating

A coating composition and guide wire technology, applied in the direction of coating, packaging item types, special packaging items, etc., can solve the problems of easy falling off and poor firmness of hydrophilic coating, avoid falling off and improve smoothness and biocompatibility, good hydrophilic effect

Active Publication Date: 2020-09-01
江门市泰乐医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Prepare a hydrophilic coating on the surface of the medical interventional guide wire, and choose ordinary hydrophilic substances to coat

Method used

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  • Guide wire coating composition, guide wire coating and preparation method of guide wire coating
  • Guide wire coating composition, guide wire coating and preparation method of guide wire coating

Examples

Experimental program
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Example Embodiment

[0089] In one embodiment, the preparation method of the polymerizable macromolecular photoinitiator includes the following steps:

[0090] (1) Add 0.1mol diphenylmethane-4,4'-diisocyanate and 2mL dibutyltin dilaurate to ethyl acetate, heat to 40℃, and slowly add 0.1mol 2-hydroxy-2- Methyl-1-phenyl-1-acetone, heated to 50°C and reacted for 4 hours to obtain an intermediate;

[0091] (2) Add 0.05 mol of bisphenol A epoxy diacrylate to the intermediate described in step (1), and then add 4 mL of dibutyltin dilaurate, heat to 70°C for 5 hours, and distill off ethyl acetate to obtain the result The polymerizable macromolecular photoinitiator.

[0092] The applicant found that the use of small molecule photoinitiators for UV curing has problems such as residue, volatilization and migration of the small molecule photoinitiators. On the one hand, it will reduce the photoinitiation efficiency, and on the other hand, it will cause the coating to age yellow and cause odors. And toxicity. The...

Example Embodiment

[0107] Example 1

[0108] Embodiment 1 provides a guide wire coating composition, which includes a top coating solution and a bottom coating solution; the mass ratio of the top coating solution and the bottom coating solution is 0.8:1;

[0109] The surface coating solution includes polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, polymethyl vinyl ether / maleic anhydride copolymer; the polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, polymethylethylene The mass ratio of the base ether / maleic anhydride copolymer is 0.7:1.3:1:1.5; the weight percentage of the polyvinylpyrrolidone in the surface coating solution is 0.8%; the solvent in the surface coating solution is water;

[0110] The polyacrylamide is cationic polyacrylamide, the brand is CP40, purchased from Henan Debang Water Treatment Material Co., Ltd.; the hyaluronic acid is pharmaceutical grade hyaluronic acid, purchased from Shandong Runxin Pharmaceutical Co., Ltd.; The polyvinylpyrrolidone is PVP K25, purchased fr...

Example Embodiment

[0118] Example 2

[0119] Embodiment 2 provides a guide wire coating composition, which includes a top coating solution and a bottom coating solution; the mass ratio of the top coating solution and the bottom coating solution is 1.4:1;

[0120] The surface coating solution includes polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, polymethyl vinyl ether / maleic anhydride copolymer; the polyacrylamide, hyaluronic acid, polyvinylpyrrolidone, polymethylethylene The mass ratio of the base ether / maleic anhydride copolymer is 1.1:1.6:1:2.4; the weight percentage of the polyvinylpyrrolidone in the surface coating solution is 0.8%; the solvent in the surface coating solution is water;

[0121] The polyacrylamide is cationic polyacrylamide, the brand is CP40, purchased from Henan Debang Water Treatment Material Co., Ltd.; the hyaluronic acid is pharmaceutical grade hyaluronic acid, purchased from Shandong Runxin Pharmaceutical Co., Ltd.; The polyvinylpyrrolidone is PVP K25, purchased fr...

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Abstract

The invention relates to the field of medical coatings, in particular to a guide wire coating composition, a guide wire coating and a preparation method of the guide wire coating. The guide wire coating composition at least comprises following raw materials: a surface coating solution and a bottom coating solution, wherein the surface coating solution comprises a hydrophilic polymer; the bottom coating solution includes a polymer with an acrylic functional group and a urethane group and a photoinitiator. The prepared guide wire coating is good in smoothness and excellent in biocompatibility, the situation that the water absorption expansion capacity of the guide wire coating is too high is avoided, and the anticoagulation effect is improved. The problems of residue, volatilization, migration and the like of a photoinitiator are solved, the adhesive force between a guide wire and the coating is improved, an interpenetrating network structure can be formed by the guide wire coating and the surface coating, the surface coating is prevented from falling off, and the stability of the surface coating is kept while good hydrophilicity is shown.

Description

technical field [0001] The invention relates to the field of medical material coatings, in particular to a guide wire coating composition, a guide wire coating and a preparation method for the guide wire coating. Background technique [0002] The medical interventional guide wire is mainly used to guide the medical catheter, and is used to assist the catheter to accurately enter the blood vessel and other cavity where the disease occurs, and guide the catheter to reach the designated position smoothly. Its outermost layer is coated with thermoplastic polyurethane, and its surface energy is low. , Strong hydrophobicity, when the guide wire enters the small blood vessel branch, it is easy to cause greater friction with the blood vessel wall, causing the rupture of the blood vessel wall, which affects the doctor's clinical operation. In order to solve the problem of excessive friction during use, in theory, a hydrophilic coating can be prepared on the surface of the guide wire ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/14A61L33/06A61L33/08
CPCA61L31/10A61L31/14A61L33/064A61L33/068A61L33/08A61L2420/02A61L2420/08C08L39/06C08L75/14
Inventor 王洪强陈芳叶翠萍潘伟凤沈友红罗小娟李建卿王伟业温国坚李杰然柯景超梁焕敏
Owner 江门市泰乐医疗科技有限公司
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