Preparation method of mecobalamin dispersible tablets

Abstract

The invention provides a preparation method of mecobalamin dispersible tablets, which comprises the following steps: adding a part of microcrystalline cellulose into a three-dimensional mixer, addinga mecobalamin raw material, and mixing to obtain a mixture I; rinsing the tank body of the three-dimensional mixer with lactose, adding the rinsed lactose and the mixture I into the multi-dimensionalmixer, adding croscarmellose sodium and the other part of microcrystalline cellulose into the multi-dimensional mixer, and mixing to obtain a mixture II. The invention provides a preparation method ofmecobalamin dispersible tablets. A direct tabletting method is adopted; links such as granulation, size stabilization and drying are omitted; the method has the characteristics of short process route, high production efficiency, low energy consumption and few degradation impurities; the materials are fully and uniformly mixed by three steps, the mecobalamin raw material can be uniformly distributed in the dispersible tablet, and the obtained mecobalamin dispersible tablet has much lower impurity content and higher purity than the mecobalamin dispersible tablet prepared by the existing wet granulation process.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a method for preparing methylcobalamin dispersible tablets. Background technique [0002] Methylcobalamin drugs are used for the treatment of peripheral nerve diseases and megaloblastic anemia caused by vitamin B12 deficiency. Compared with other vitamin B12 drugs, methylcobalamin has better transmission in the nervous system and can promote the metabolism of nucleic acid, protein and fat. Pharmacologically, it repairs damaged peripheral nerves by promoting the synthesis of nucleic acid, protein and nerve myelin sheath in nerve cells. Clinically, methylcobalamin drugs have obvious effects on peripheral nerve diseases such as diabetic neuropathy and multiple neuritis, especially on numbness, pain and paralysis. They are currently effective drugs for clinical treatment of such diseases with minimal side effects. In addition, studies have shown that methylcobalamin is ...

AI Technical Summary

Problems solved by technology

The existing preparation process adopts the method of adding equal amounts for mixing, which needs to be weighed many times, mixed for no less than 6 times, and then wet granulated. It takes about 2 hours to prepare 600,000 pieces of granules. The raw material of methylcobalamin is being processed Contact with water during wet granulation, the product is unstable in dissolved state, and related substances will increase

Images