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Full-bioabsorbable composite material and application thereof, intravascular stent, and preparation methods of full-bioabsorbable composite material and intravascular stent

A technology for absorbing composite materials and vascular stents, which is applied in the field of biological materials and can solve problems such as uncontrollable degradation rate, enhanced support strength, and blocked blood vessels.

Inactive Publication Date: 2020-10-30
郑柳春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the vascular stent materials using iron alloy and magnesium alloy have defects, such as: slow corrosion rate, corrosion products block blood vessels, and uncontrollable degradation rate, which easily leads to accumulation of metal ions
However, in the technical solution disclosed in this patent document, the enhancement of support strength is not involved

Method used

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  • Full-bioabsorbable composite material and application thereof, intravascular stent, and preparation methods of full-bioabsorbable composite material and intravascular stent
  • Full-bioabsorbable composite material and application thereof, intravascular stent, and preparation methods of full-bioabsorbable composite material and intravascular stent
  • Full-bioabsorbable composite material and application thereof, intravascular stent, and preparation methods of full-bioabsorbable composite material and intravascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Dry polyhydroxybutyric acid at 100°C for 12 hours in advance, weigh polyhydroxybutyric acid and cellulose nanocrystals in total 300g, wherein polyhydroxybutyric acid accounts for 95wt% of the total mass percentage, and cellulose nanocrystals accounts for the total mass percentage It is 5 wt%, and the above components are mixed uniformly and then added to a twin-screw extruder for mixing, extruding and granulating.

[0044] The parameters of the twin-screw extruder are set as follows:

[0045]

[0046] The pellets obtained by mixing and blending in a twin-screw extruder were dried at 100°C for 12 hours and then placed in a small injection molding machine. The pellets in the molten state are extruded into a molten mold to obtain a blood vessel stent with an outer diameter of 5 mm and a wall thickness of 0.3 mm.

[0047] Adopt polylactic acid and paclitaxel (the polylactic acid that is 95 parts by mass: the paclitaxel that is 5 parts by mass) is dissolved in chloroform...

Embodiment 2

[0049] The poly-L-lactic acid was dried at 100°C for 12 hours in advance, and a total of 300 g of polyhydroxybutyric acid and starch nanocrystals were weighed. The poly-L-lactic acid accounted for 70 wt % of the total mass percentage, and the starch nano-crystals accounted for 30 wt % of the total mass percentage. After the components are mixed evenly, they are added to a twin-screw extruder for mixing, extrusion and granulation. The parameters of the twin-screw extruder are set as follows:

[0050]

[0051] The pellets obtained by mixing and blending in a twin-screw extruder were dried at 100°C for 12 hours, then placed in a small injection molding machine, and the temperature was raised to 195°C to melt. The pressure of the extrusion head was 6 MPa, and the pellets obtained by mixing were heated to a molten state. The pellets in the molten state are extruded into a molten mold for extrusion to obtain a vascular stent with an outer diameter of 7 mm and a wall thickness of ...

Embodiment 3

[0054] Dry polycaprolactone at 40° C. for 12 hours in advance, weigh polycaprolactone and chitosan nanocrystals in total 300 g, polycaprolactone accounts for 80 wt % of the total mass percentage, and starch nano crystals accounts for 20 wt % of the total mass %, the above components are mixed uniformly and then added to a twin-screw extruder for mixing, extrusion and granulation. The parameters of the twin-screw extruder are set as follows:

[0055] The parameters of the twin-screw extruder are set as follows:

[0056]

[0057] The pellets obtained by mixing and blending in a twin-screw extruder were dried at 40°C for 12 hours, then placed in a small injection molding machine, and the temperature was raised to 90°C to melt. The pressure of the extrusion head was 1 MPa, and the pellets obtained by mixing were heated to a molten state. The pellets in the molten state are extruded into a molten mold for extrusion to obtain a blood vessel stent with an outer diameter of 20 mm ...

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Abstract

The invention discloses a full-bioabsorbable composite material. The full-bioabsorbable composite material comprises a full-bioabsorbable polymer and bio-based nanocrystals. In addition, the inventionfurther discloses application of the full-bioabsorbable composite material. The full-bioabsorbable composite material is used for manufacturing an intravascular stent. The invention also discloses apreparation method of the full-bioabsorbable composite material. The preparation method of the full-bioabsorbable composite material comprises the step of blending the bioabsorbable polymer and the bio-based nanocrystals. Furthermore, the invention also discloses a preparation method of the intravascular stent. The preparation method of the intravascular stent comprises the following steps: preparation of the intravascular stent: extruding the full-bioabsorbable composite material through a melting mold to obtain the intravascular stent; and surface modification: carrying out surface modification on the intravascular stent. Finally, the invention further discloses the intravascular stent which is prepared by using the preparation method. When the bioabsorbable composite material is appliedto the intravascular stent, the obtained intravascular stent has the advantages of good mechanical property, good biocompatibility and good biodegradability.

Description

technical field [0001] The invention belongs to the field of biomaterials, and in particular relates to a biomaterial for a vascular stent, a use, a preparation method, a vascular stent and a preparation method thereof. In particular, it relates to a high-performance fully bioabsorbable vascular stent and a preparation method thereof. Background technique [0002] With the change of lifestyle and diet structure, cardiovascular and cerebrovascular diseases have gradually become the main diseases that threaten national health. The implantation of vascular stents is also becoming more and more common, and has become the most effective means of treating cardiovascular and cerebrovascular diseases. [0003] Metal stent materials such as stainless steel, NiTi alloy, and cobalt-chromium alloy have become important preparation materials for traditional vascular stents due to their good biocompatibility and radial support. However, these metal stent materials are not biodegradable....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L1/04C08L3/02C08L5/08A61L31/06A61L31/08A61L31/14A61L31/16
CPCC08L67/04A61L31/06A61L31/08A61L31/148A61L31/16A61L2300/216A61L2300/42C08L1/04C08L3/02C08L5/08
Inventor 郑柳春
Owner 郑柳春
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