Synthetic method of octadecanedioic acid mono-tert-butyl ester

Abstract

The invention relates to the field of organic synthesis, in particular to a synthesis method of octadecanedioic acid mono-tert-butyl ester, which comprises the following steps: carrying out reflux esterification on sebacic acid and methanol to obtain octadecanedioic acid monomethyl ester, reacting the octadecanedioic acid monomethyl ester with isobutene under the action of a composite catalyst, concentrating, alkalizing the concentrated solution, extracting, drying and filtering. Compared with the prior art, the method has the advantages that the selectivity is good, the reaction conversion rate is high, the total yield of a final product reaches 96% or above, and the purity reaches 95% or above. The adopted composite catalyst is different from a traditional acid catalyst, Fe<3+> is dopedin bismuth vanadate, bismuth vanadate crystal lattices can be introduced into defect positions, the crystallinity is changed, and the proton or electron trapping capacity of a semiconductor can be enhanced; photocatalyst activity is improved, the bismuth vanadate is loaded on the surface of lignin amine to form a core / membrane structure used for catalyzing esterification of carboxylic acid and olefin, and the catalyst can be separated and recycled by means of magnetic separation and the like, and can be repeatedly used for multiple times without reduction in catalytic effect.

Description

technical field [0001] The invention relates to the field of organic synthesis, in particular to a method for synthesizing mono-tert-butyl octadecanedicarboxylate. Background technique [0002] Diabetes mellitus is a common multiple metabolic disease, and its incidence is on the rise both at home and abroad. According to incomplete statistics, there are more than 30 million people with diabetes in the country, and the incidence of diabetes is as high as 3.2%. Although many diseases can kill people, diabetes is the third leading cause of death. [0003] Insulin is a specific peptide hormone compound for the treatment of diabetes, and there is no more effective alternative drug so far. However, since insulin is a protein that is easily hydrolyzed by proteases in the gastrointestinal tract and loses its activity, it can only be used by injection and cannot be administered in other ways. For insulin-dependent patients, to maintain the normal metabolism of life, frequent injec...

AI Technical Summary

Problems solved by technology

However, since insulin is a protein that is easily hydrolyzed by proteases in the gastrointestinal tract and loses its activity, it can only be used by injection and cannot be administered in other ways

For insulin-dependent patients, in order to maintain the normal metabolism of life, frequent injections of drugs are necessary, which brings great pain and inconvenience to such patients

Mono-tert-butyl octadecanedicarboxylate is an important intermediate for the synthesis of long-acting insulin. The current preparation process has poor selectivity, and it is difficult to obtain the target product with high purity. The yield is low; due to the limitation of the preparation process, its large-scale production is limited. , which also limits its application in real production

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