Synthesis method of mitochondria-targeting nano triphenylphosphine MoS2 quantum dots

A technology of triphenylphosphine and synthesis method, applied in the direction of nanotechnology, nano-optics, nanotechnology, etc., can solve the problems of poor biocompatibility of drugs, low bioavailability, complex synthesis method, etc., and the method is simple and easy to operate , low-cost effect

Inactive Publication Date: 2020-11-03
NANKAI UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

However, the current related mitochondria-targeted drug synthesis methods are complex and costly, and the drug itself has poor biocompatibility and low bioavailability, making it difficult to truly exert its drug effect in the nervous system.

Method used

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  • Synthesis method of mitochondria-targeting nano triphenylphosphine MoS2 quantum dots
  • Synthesis method of mitochondria-targeting nano triphenylphosphine MoS2 quantum dots
  • Synthesis method of mitochondria-targeting nano triphenylphosphine MoS2 quantum dots

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Embodiment

[0030] Example: Synthesis of triphenylphosphine molybdenum disulfide quantum dots and its targeting to the mitochondria of microglial cells, figure 1 Synthesis flow chart of triphenylphosphine molybdenum disulfide quantum dots.

[0031] 1. Synthesis of DSPE-PEG-TPP

[0032] (1) Stirring and mixing: 20 μmol (3-carboxypropyl) triphenylphosphine bromide, 60 μmol N-(3-dimethylaminopropyl)-N-ethyldiimine hydrochloride, 60 μmol N- Hydroxysuccinimide and 20 μl triethylamine were mixed and dissolved in 1 ml chloroform. The mixture was placed on a magnetic stirrer and stirred at room temperature for 2 h at a stirring speed of 1000 rpm. Then 50mg DSPE-PEG-NH 2 Dissolve it in 2ml of chloroform, and stir the mixture of the two at room temperature for 24h at a stirring speed of 1000rpm.

[0033] (2) Vacuum drying: the above mixed solution was vacuum-dried in a vacuum drying oven at 37° C. for 4 hours, and taken out after all the chloroform was volatilized.

[0034] (3) Dialysis: Add h...

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Abstract

The invention discloses a synthesis method of mitochondria-targeting nano triphenylphosphine MoS2 quantum dots. The preparation method comprises the following steps: firstly, combining amine-modified1 2-distearoyl-sn-glycerin-3phosphoric acid ethanolamine-n-[amino-(polyethylene glycol)-2000] and (3-carboxylpropyl)-triphenylphosphine bromide together through an amino coupling reaction by using a cross-linking agent N-(3-dimethylaminopropyl)-N-ethyl diimine hydrochloride with the length of zero to form DSPE-PEG-GTPP; then, mixing the DSPE-PEG-GTPP and the molybdenum disulfide quantum dot in trichloromethane, wherein the hydrophobic end distearoyl phosphatidyl ethanolamine of the DSPE-PEG-GTPP is connected to the surface of the molybdenum disulfide quantum dot, the (3-carboxylpropyl)-triphenylphosphine bromide end extends outwards, and thus the triphenylphosphine molybdenum disulfide is obtained. The synthesized triphenylphosphine molybdenum disulfide quantum dot can target mitochondria,and a new way is provided for research of mitochondria-related nervous system diseases and mechanisms.

Description

technical field [0001] The invention belongs to the field of environmental nanotechnology, in particular to a nano-triphenylphosphine MoS targeting mitochondria 2 Synthesis of quantum dots. Background technique [0002] Once inside a living organism, nanomaterials encounter a very complex physiological environment that is good at recognizing and removing foreign substances. For example, there are various proteins and cellular components in the blood, and foreign substances may lose their original effect when encountering any of them. In addition, nanomaterials are easily absorbed by reticuloendothelial tissue. Therefore, nanomaterials must overcome this obstacle if they want to reach the target position. After reducing the non-specific absorption of nanoparticles, the addition of the targeting system will help the nanomaterials to accumulate preferentially at the target location, thereby improving the therapeutic effect. All in all, it is a very difficult task to design a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/68A61K49/00B82Y20/00B82Y40/00C08G65/327
CPCC09K11/025C09K11/681A61K49/0067A61K49/0052A61K49/0021B82Y20/00B82Y40/00C08G65/327
Inventor 周启星任朝秀
Owner NANKAI UNIV
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