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Nano-medicine based on polyphenol complex and preparation method thereof

A technology of nano-drugs and complexes, applied in the direction of nano-drugs, drug combinations, nanotechnology, etc., can solve the problems of low bioavailability, poor water solubility, non-specific distribution, etc., achieve low acquisition cost, good clinical transformation, and improve drug quality. effective effect

Active Publication Date: 2022-03-11
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, nanomedicine can also overcome some defects of traditional drugs, such as poor water solubility, low bioavailability and non-specific distribution in the body, etc.

Method used

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  • Nano-medicine based on polyphenol complex and preparation method thereof
  • Nano-medicine based on polyphenol complex and preparation method thereof
  • Nano-medicine based on polyphenol complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The steps of this embodiment are as follows:

[0039] (1) Preparation of Epigallocatechin Gallate (EGCG) Complex

[0040] Raw material ratio (weight part) and process parameter are shown in Table 1, respectively EGCG, glycine and formaldehyde, EGCG, cysteine ​​and formaldehyde are dissolved in deionized water to form two kinds of reaction systems, then two kinds of reaction systems are respectively in 25 Stir and react at ℃ for 12 hours, then centrifuge the obtained reaction solution for solid-liquid separation, and wash the separated solid product with deionized water to obtain two nanocomposites EGCG-glycine and EGCG-cysteine;

[0041] Table 1: Raw material ratio (parts by weight) and process parameters

[0042]

[0043] (2) Preparation of nanomedicine

[0044] 1. the nanocomposite EGCG-glycine and EGCG-cysteine ​​prepared by step (1) are dissolved in ethanol with a mass concentration of 30% respectively to form a concentration of EGCG-glycine and EGCG-cysteine ​...

Embodiment 2

[0062] The steps of this embodiment are as follows:

[0063] (1) The nanocomposite EGCG-cysteine ​​prepared in Example 1 is dissolved in ethanol with a mass concentration of 30% to form a concentration of EGCG-cysteine ​​solution of 10 mg / mL, and paclitaxel is dissolved in 30% ethanol Formed paclitaxel solutions with concentrations of 10mg / mL, 20mg / mL and 50mg / mL respectively;

[0064] (2) The EGCG-cysteine ​​solution prepared in step (1) and the paclitaxel solutions of 3 different concentrations are measured according to the weight ratio of the nanocomposite and the drug in the mixed solution described in Table 4, and are placed at room temperature and normal pressure. They are mixed evenly respectively to form 3 kinds of mixtures;

[0065] Table 4: The composition of the mixed solution and the weight ratio of nanocomposites and drugs in the mixed solution

[0066]

[0067] (3) Deionized water is used as the assembly solution, and the volume ratio of the mixture to the a...

Embodiment 3

[0071] The steps of this embodiment are as follows:

[0072] (1) Preparation of Phloroglucinol Complex

[0073] Using phloroglucinol, cysteine ​​amino acid, and formaldehyde as raw materials, the weight ratio of phloroglucinol, cysteine ​​amino acid, and formaldehyde is 10:2:4, and phloroglucinol, amino acid, and formaldehyde are dissolved in deionized water to form a reaction system, and then the reaction system was stirred and reacted at 20°C for 12 hours, and then the obtained reaction solution was centrifuged for solid-liquid separation, and the separated solid product was washed with deionized water to obtain the phloroglucinol nanocomposite;

[0074] (2) Preparation of nanomedicine

[0075] ①Dissolve the phloroglucinol nanocomposite prepared in step (1) with tetrahydrofuran to form a phloroglucinol complex solution with a concentration of 10 mg / mL, and paclitaxel, hydroxycamptothecin, ursolic acid, ellagic acid, Quercetin, trametinib, sorafenib, dexamethasone, budesoni...

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Abstract

The preparation method of the nano-medicine based on the polyphenol complex according to the present invention, the process steps are as follows: (1) prepare the polyphenol complex solution and the drug solution; (2) prepare the polyphenol complex solution and the drug solution at room temperature and normal pressure Mixed evenly to form a mixed solution, the polyphenol complex solution and the drug solution are measured according to the weight ratio of the polyphenol compound and the drug in the mixed solution (10~1):(1~10); (3) at room temperature, Add the mixed solution to the assembly solution under normal pressure, or add the assembly solution to the mixed solution to form a recombination system, and then let it stand for at least 5 minutes to complete the recombination to form a nanomedicine, then perform solid-liquid separation, and then separate the solid product Wash and dry. The above method can not only simplify the process and reduce the cost of nano-medicines, but also provide a variety of nano-medicines, and the drug content in the nano-medicines can reach up to about 90%, and the drug capture rate can reach more than 80%.

Description

technical field [0001] The invention belongs to the technical field of nano-medicines, and relates to nano-medicines based on polyphenol complexes and a preparation method thereof. Background technique [0002] The unbearable serious side effects of chemotherapy drugs have limited their application. Encouragingly, a lot of clinical evidence shows that nanomedicine ( and ) can significantly improve patient compliance by reducing systemic toxicity and dosing frequency. In addition, nanomedicine can also overcome some defects of traditional drugs, such as poor water solubility, low bioavailability, and nonspecific distribution in the body. To sum up, nanomedicine shows broad application prospects in clinical treatment. [0003] Although many papers have been published on nanomedicines and their preparation methods, the number of nanomedicines approved for use is just "a drop in the ocean" compared with those studied in laboratories and preclinical trials. There are many ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/54A61K45/00A61K31/337A61K31/704A61P35/00B82Y5/00
CPCA61K47/545A61K47/54A61K45/00A61K31/337A61K31/704A61P35/00B82Y5/00
Inventor 李旭东易增陈光灿陈翔宇
Owner SICHUAN UNIV
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