A kind of compound and its preparation method and application

A compound, methyl phenyl technology, applied in the field of compound and its preparation, achieves the effect of simple synthesis process, good inhibitory activity and easy recovery
CN111892540BActive Publication Date: 2022-01-28NANJING FORESTRY UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING FORESTRY UNIV
Publication Date
2022-01-28

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Abstract

The invention discloses a compound, its preparation method and application. The present invention uses isolongifolanone derivatives 3-aryl-5,5,9,9-tetramethyl-4,5,5a,6,7,8,9,9a-octahydro-5a,8- The isolongylyl indazoles were prepared from endomethylene benzo[g]indazole as raw material and acylating reagent with aroyl chloride. The anti-tumor activity of the synthesized compounds was tested, and the results showed that the prepared compounds had good inhibitory activity on human breast cancer cell MCF-7, human lung cancer cell A549 and human cervical cancer cell Hela, and had good Antitumor medicinal value.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis and drug synthesis, and relates to a compound and its preparation method and application. Background technique

[0002] Tumor has always been the number one killer that endangers human health and life, so the development of anti-tumor drugs is the focus of new drug research and development. Since ancient times, natural products have been a treasure trove of medicines that humans have used to find relief from ailments. With the rapid development of science and technology, people's understanding of the structure and biological activity of natural products is constantly deepening, from the direct use of natural products, to the introduction of chemical small molecule functional groups to modify natural products, and then to the introduction of total synthesis strategy imitation Nature produces biologically active substances. It is precisely because of this uniqueness of natural products t...

Claims

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