Preparation method for 2-methoxy-N-(2-nitro-5-phenylthio) phenylacetamide

A technology of phenylacetamide and phenylthioaniline, which is applied in the field of preparation of 2-methoxy-N-phenylacetamide, can solve the problems affecting the conversion rate of reduced product quality, reduction catalyst poisoning, wastewater treatment difficulties, etc. , to achieve the effects of green and environmentally friendly industrialized production, lower wastewater treatment costs, and easy industrialized production
CN111978223AActive Publication Date: 2020-11-24CHANGZHOU YABANG QH PHARMACHEM +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHANGZHOU YABANG QH PHARMACHEM
Publication Date
2020-11-24

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Abstract

The invention discloses a preparation method for 2-methoxy-N-(2-nitro-5-phenylthio) phenylacetamide. The preparation method comprises the following steps: in a non-polar organic solvent, under catalysis of an acid binding agent, 2-nitro-5-phenylthio-aniline and methoxyacetic acid are added, and have a chlorination reaction with thionyl chloride under reflux; after the reaction ends, excess thionylchloride is decomposed by water, standing is performed for layering; the solvent is concentrated, a solvent with poor dissolvability is added for cooling crystallization, and suction filtration and drying are performed to obtain the 2-methoxy-N-(2-nitro-5-phenylthio) phenylacetamide. The preparation method adopts a one-pot method, and uses the thionyl chloride to replace phosphorus trichloride, so that the product purity reaches 99.8% or more, and the yield reaches 93.5% or more. The method has the advantages of being simple to operate, environmental-friendly, easy to industrially produce andthe like.
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Description

technical field

[0001] The invention relates to the technical fields of medicine and chemical industry, in particular to a preparation method of 2-methoxy-N-(2-nitro-5-phenylthio)phenylacetamide. Background technique

[0002] The broad-spectrum anthelmintic drug Febante1, also known as benzoguanidine, is mainly used for the treatment and control of gastrointestinal roundworms, lungworms, tapeworms, etc. in cattle, sheep, pigs, horses and other animals. It has high efficiency and low toxicity , The residence time in the body is short, and the safety range is large. The chemical name of non-bantyr (1) is [[2-[(methoxyacetyl)amino]-4-(phenylthio)phenyl]carbimino]biscarbamate dimethyl ester, the first It was successfully developed by Bayer Pharmaceutical Company of Germany, and its synthetic route is rarely reported in China.

[0003]

[0004] During the preparation of Febantyr, one of the key intermediates is 2-methoxy-N-(2-nitro-5-phenylthio)phenylacetamide (2), which is ...

Claims

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