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Method for recycling zinc and iodine-containing waste material resources in pharmaceutical industry

An industrial and pharmaceutical technology, applied in the field of recycling of zinc-containing and iodine waste resources in the pharmaceutical industry, can solve the problems of low recovery rate, low yield, and inability to directly prepare iodide, and achieve the effect of reducing treatment costs and reducing environmental pollution.

Pending Publication Date: 2020-12-08
山东博苑医药化学股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] This waste solution contains organic matter such as methanol. The general conventional treatment method needs to be distilled first, and then oxidized with dilute sulfuric acid, hydrochloric acid, and hydrogen peroxide to produce iodine, because the iodine content in the waste liquid is relatively low and contains a large amount of organic matter. Iodine, the yield is low below 70%, the quality of iodine is poor, the content is no more than 80%, and contains a large amount of organic matter, can not directly prepare iodide, needs refining, increases cost; The comprehensive utilization rate of iodine has only 60~65%, recovery rate Low
[0004] In addition, a large amount of zinc in the waste is discharged in the form of zinc sulfate or zinc chloride, causing serious pollution to the environment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Pour 3000Kg of iodine-containing 3.5% into the reactor, waste liquid produced in the production process of ticagrelor containing 5.5% zinc, start stirring, adjust solution pH8.7 with 20% sodium carbonate, stir and crystallize for 60 minutes, make zinc The ions are fully precipitated into zinc carbonate, centrifuged, dried, and the filter cake is fully washed with 300Kg of water to obtain 342Kg of zinc carbonate wet product, and the iodine content in it is 0.04% by sampling, and the adsorption loss of iodine by zinc carbonate is 0.14Kg. Combine the filtrates, iodine exists in the filtrate in the form of sodium iodide, and the filtrate is incinerated at 1100° C. with an incinerator. The methanol in the filtrate is used as fuel, and other organic matters in the filtrate are completely incinerated to obtain a sodium iodide solution that removes organic matter.

[0026] The obtained zinc carbonate filter cake was incinerated in a converter to obtain 203.5 kg of zinc oxide wit...

Embodiment 2

[0029] Squeeze into 3000Kg containing iodine 3.5% in reactor, the waste liquid that produces in the ticagrelor production process that contains zinc 5.5%, open stirring, adjust solution pH9.0 with 20% sodium carbonate, stirring crystallization 60 minutes, make zinc The ions are fully precipitated into zinc carbonate, centrifuged, dried, and the filter cake is fully washed with 300Kg water to obtain 344Kg of zinc carbonate wet product, and the iodine content in it is 0.045% by sampling and 0.15Kg of iodine is lost by zinc carbonate adsorption. Combine the filtrates, iodine exists in the filtrate in the form of sodium iodide, and the filtrate is incinerated at 1100° C. with an incinerator. The methanol in the filtrate is used as fuel, and other organic matters in the filtrate are completely incinerated to obtain a sodium iodide solution that removes organic matter.

[0030] The obtained zinc carbonate filter cake was incinerated in a converter to obtain 204.5 kg of zinc oxide wit...

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Abstract

The invention relates to a method for recycling zinc and iodine-containing waste materials in the pharmaceutical industry, in particular to a method for recycling ticagrelor medical waste liquid resources, and is used for recycling iodine and zinc in iodine-containing waste liquid generated in the ticagrelor production process. The method comprises the following steps: firstly, adjusting the pH value of the solution to 8.5-9.0 by using a 20% sodium carbonate solution, enabling zinc ions in the solution to generate zinc carbonate precipitate, and incinerating zinc carbonate by using a converterto obtain zinc oxide with very high purity, thereby realizing cyclic utilization of zinc resources. Removing all organic matters in the waste liquid by using a high-temperature incineration method; and oxidizing the iodine-containing brine obtained after incineration to obtain iodine, and washing with water to remove various miscellaneous salts, thereby obtaining iodine. The recovery rate of iodine reaches 95% or above, and the recovery rate of zinc resources reaches 99% or above.

Description

technical field [0001] The invention relates to a method for recycling zinc and iodine waste resources in the pharmaceutical industry, in particular to a recovery process for iodine and zinc in iodine-containing waste liquid produced in the production process of ticagrelor. Background technique [0002] Ticagrelor is a new highly selective small molecule anticoagulant drug with unique pharmacological effects and broad market prospects. During the synthesis of the most critical intermediate (1S,2R,3S,4R)-2,3-o-isopropylidene-4-aminocyclopentane-1,2,3-triol in the synthesis of ticagrelor, Sodium iodide is used to generate iodide, and then zinc powder is used to remove iodine, and methanol is used as solvent. Therefore, the reaction mother liquor contains zinc iodide, and iodine is a scarce resource. It is very meaningful to recover iodine from waste liquid. [0003] This waste solution contains organic matter such as methanol. The general conventional treatment method needs t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G9/02C01B7/14
CPCC01G9/02C01B7/14C01P2006/80
Inventor 刘会军刘亚琪邢晓宇李成林于国清
Owner 山东博苑医药化学股份有限公司