Antibacterial adhesive bandage containing zinc oxide nanoparticles and preparation method thereof

A zinc oxide nano and band-aid technology, which is applied in the field of medical supplies, can solve problems such as poor air permeability, affecting cell regeneration, wound healing, and difficult wound healing, so as to prevent secondary infection of bacteria, accelerate wound healing, and reduce allergies Effect

Active Publication Date: 2020-12-15
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional band-aids have poor air permeability, which can easily cause the reproduction of anaerobic bacteria such as staphylococcus an

Method used

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  • Antibacterial adhesive bandage containing zinc oxide nanoparticles and preparation method thereof
  • Antibacterial adhesive bandage containing zinc oxide nanoparticles and preparation method thereof
  • Antibacterial adhesive bandage containing zinc oxide nanoparticles and preparation method thereof

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preparation example Construction

[0016] The invention discloses an antibacterial band-aid containing zinc oxide nanoparticles, and the operation steps of its preparation method are as follows:

[0017] (1) Accurately weigh the required milk thistle extract, chitosan quaternary ammonium salt, growth factors, amino acids and multivitamins with an analytical balance in the weighing laboratory, accurate to two decimal places;

[0018] (2) Accurately measure the ultrapure water required for preparation by graduated cylinder and pipette;

[0019] (3) Add ultra-pure water into the beaker, under stirring at a speed of 50~150r / min, add artichoke extract, chitosan quaternary ammonium salt, growth factors, amino acids and multivitamins successively, stir to dissolve and make The solution is mixed evenly;

[0020] (4) Put the non-woven fabric of the drug layer into the dipping tank, soak for 1 ~ 10min, then put into an oven at 40 ~ 50°C to dry, repeat the above steps twice;

[0021] (5) Immerse the chitosan non-woven f...

Embodiment 1

[0025] (1) Accurately weigh 5.00g of thistle extract, 2.00g of chitosan quaternary ammonium salt, 0.02g of growth factor, 1.00g of amino acid and 1.00g of multivitamin by analytical balance in the weighing laboratory, accurate to the decimal point last two digits;

[0026] (2) Accurately measure 90.98ml of ultrapure water through a graduated cylinder and a pipette;

[0027] (3) Add ultrapure water into the beaker, and under stirring at a speed of 120r / min, add the extract of thistle, chitosan quaternary ammonium salt, growth factors, amino acids and multivitamins in sequence, stir to dissolve and mix the solution Uniform;

[0028] (4) the drug layer non-woven fabric is put into the dipping tank, soaked for 10min, then put into 45°C oven for drying, repeat the above steps twice;

[0029] (5) The chitosan non-woven fabric was immersed in the finishing solution containing nano-sized zinc oxide for 10min at 30°C. Dry at 40 DEG C then, repeat above-mentioned steps twice;

[003...

Embodiment 2

[0033] (1) Accurately weigh the required 6.00g of thistle extract, 3.00g of chitosan quaternary ammonium salt, 0.02g of growth factor, 1.00g of amino acid and 1.00g of multivitamin by analytical balance in the weighing laboratory, accurate to the decimal point last two digits;

[0034] (2) Accurately measure 88.98ml ultrapure water by measuring cylinder and pipette;

[0035] (3) Add ultrapure water into the beaker, and under stirring at a speed of 120r / min, add the extract of thistle, chitosan quaternary ammonium salt, growth factors, amino acids and multivitamins in sequence, stir to dissolve and mix the solution Uniform;

[0036] (4) the drug layer non-woven fabric is put into the dipping tank, soaked for 10min, then put into 45°C oven for drying, repeat the above steps twice;

[0037] (5) The chitosan non-woven fabric was immersed in the finishing solution containing nano-sized zinc oxide for 10min at 30°C. Dry at 40 DEG C then, repeat above-mentioned steps twice;

[00...

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Abstract

The invention discloses an antibacterial adhesive bandage containing zinc oxide nanoparticles and a preparation method thereof, and belongs to the technical field of medical supplies. The prepared adhesive bandage consists of an adhesive backing, a drug layer, a chitosan nonwoven layer and strippable layers. The chitosan nonwoven layer contains nano zinc oxide connected through an immersion method; and medicament containing Chinese herbal medicinal ingredients is attached to the drug layer and includes a field thistle extract, chitosan quaternary ammonium salt, growth factors, amino acid, decavitamin and other ingredients. Thus, the problems that existing adhesive bandages cannot promote wounds to heal can be solved, and the technical effects of promoting the wounds to heal quickly and preventing the wounds from being infected can be realized. The prepared adhesive bandage is simple in manufacturing technology, good in biocompatibility, low in cost, non-irritating to the wounds and safe in product, has no toxic and side effects and can absorb the exudate from the wounds; and the adhesive bandage can be applied to the nursing care of superficial wounds such as small wounds, abrasions and cuts.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and in particular relates to an antibacterial band-aid containing zinc oxide nanoparticles and a preparation method thereof. Background technique [0002] Trauma is the damage of normal skin under the joint action of external injury factors (external force, heat, surgery, electric current, chemical substances and low temperature, etc.) and internal factors of the body (local blood supply insufficiency). The appearance of wounds is generally accompanied by the destruction of skin integrity and the loss of some normal tissues, resulting in impairment of normal skin function. Wound repair is a complex process involving multiple cells and cytokines, and wound dressings play an important role in the process of healing and repairing wounds. When using a dressing to treat a wound, the dressing can isolate external microorganisms, avoid further infection of the wound, and then use its own heali...

Claims

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Application Information

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IPC IPC(8): A61L15/40A61L15/18A61L15/28A61L15/20A61L15/42A61L15/44A61L15/46D06M15/03D06M13/00D06M13/342D06M11/44
CPCA61L15/40A61L15/18A61L15/28A61L15/20A61L15/42A61L15/44A61L15/46D06M15/03D06M13/00D06M13/342D06M11/44D06M16/00A61L2300/404A61L2400/12A61L2300/30A61L2300/414A61L2300/102A61L2300/412A61L2300/41A61L2400/04C08L5/08
Inventor 张海军鞠豪尹玉霞侯文博刘爱华张明广卢天恒曹明昆
Owner SHANDONG BRANDEN MEDICAL DEVICE
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