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Anti-infection-promoting osseointegration coating, preparation method and application of a medical metal surface

A metal surface, anti-infection technology, applied in the direction of metal material coating process, coating, pharmaceutical formulations, etc., can solve the problems of poor control of release kinetics, prone to explosive release, insufficient antibacterial ability, etc., to avoid insufficient dosage , Overcome the ability to prevent and control risks, and promote the effect of osteogenesis

Active Publication Date: 2021-09-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these antibacterial materials currently have many disadvantages: limited drug loading, the need for the body to provide a specific tissue environment, poor control of release kinetics, prone to explosive release, delayed bone repair, etc.
However, the antibacterial ability of the metal ion antibacterial coating on the metal surface in the previous technical solutions is not enough to prevent bacterial infection and biofilm formation for a long time

Method used

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  • Anti-infection-promoting osseointegration coating, preparation method and application of a medical metal surface
  • Anti-infection-promoting osseointegration coating, preparation method and application of a medical metal surface
  • Anti-infection-promoting osseointegration coating, preparation method and application of a medical metal surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 Titanium alloy loaded strontium zinc anti-infection-osseointegration coating (TC4-Sr+Zn)

[0051] (1) Material preparation: The titanium alloy (Ti-6Al-4V or TC4) sample is cut into a small square block sample of 10mm×10mm×2mm, and polished with a gradient rough sandpaper from coarse to fine until the mirror surface is bright ( 600#, 800#, 1000#, 2000#), and then use ethanol, acetone and ultrapure water to wash in sequence in an ultrasonic cleaner for 10 minutes each.

[0052] (2) Preparation of 5mol / L NaOH solution: Weigh 40 grams of NaOH powder and place it in 200 mL of ultrapure water, and place it on a magnetic stirrer to fully stir and dissolve.

[0053] (3) Alkaline heat treatment: hang the sample in a 5mol / L NaOH solution, soak it at a constant temperature of 60°C for 18 hours, and form a nanofibrous structure of sodium hydrogen titanate on the surface of the titanium alloy sample.

[0054] (4) Removal of residual NaOH: wash the sample with ultrapure wa...

Embodiment 2

[0064] Example 2 Pure titanium loaded strontium zinc anti-infection-osseointegration coating (Ti-Sr+Zn)

[0065] (1) Material preparation: The pure titanium sample is cut into a small square block sample of 10mm×10mm×2mm, and polished with a gradient rough sandpaper from coarse to fine until the mirror surface is bright (600#, 800#, 1000#, 2000#), and then washed sequentially with ethanol, acetone and ultrapure water in an ultrasonic cleaner for 10 minutes each.

[0066] (2) Preparation of 5mol / L NaOH solution: Weigh 40 grams of NaOH powder and place it in 200 mL of ultrapure water, and place it on a magnetic stirrer to fully stir and dissolve.

[0067] (3) Alkaline heat treatment: hang the sample in a 5mol / L NaOH solution, soak it at a constant temperature of 60°C for 18 hours, and form a nanofibrous structure of sodium hydrogen titanate on the surface of the pure titanium sample.

[0068] (4) Removal of residual NaOH: wash the sample with ultrapure water and absolute ethano...

Embodiment 3

[0077] Example 3 Titanium alloy loaded strontium copper anti-infection-osseointegration coating (TC4-Sr+Cu)

[0078] (1) Material preparation: The titanium alloy (Ti-6Al-4V) sample is cut into a small square block sample of 10mm×10mm×2mm, and polished with a gradient rough sandpaper from coarse to fine until the mirror surface is bright (600# , 800#, 1000#, 2000#), and then washed with ethanol, acetone and ultrapure water in an ultrasonic cleaner for 10 minutes each.

[0079] (2) Preparation of 5mol / L NaOH solution: Weigh 40 grams of NaOH powder and place it in 200 mL of ultrapure water, and place it on a magnetic stirrer to fully stir and dissolve.

[0080] (3) Alkaline heat treatment: hang the sample in a 5mol / L NaOH solution, soak it at a constant temperature of 60°C for 18 hours, and form a nanofibrous structure of sodium hydrogen titanate on the surface of the titanium alloy sample.

[0081] (4) Removal of residual NaOH: wash the sample with ultrapure water and absolute ...

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Abstract

The present invention relates to a functional coating with long-term anti-infection and high-efficiency osseointegration on the surface of medical metal and its preparation method. In the present invention, multifunctional physiologically necessary metal ions, inorganic acid radical ions, etc. The inorganic salt on the nanopore wall undergoes ion exchange and modification, and then puts it into the bionic physiological fluid for mineralization reaction. In the nanopore, the nanofiber gap and the upper surface of the fiber layer, a chemical composition similar to bone minerals and different particle size gradients are deposited. Distributed calcium phosphate coating, mineralized coating can effectively regulate the long-term release of deposited functional ions on the nanofibers, and enhance the integration efficiency and bonding strength with the bone, so as to obtain long-term anti-infection and strong osseointegration Performance: The preparation process of the present invention is simple and economical, the coating has stable functions and outstanding effects, and is applicable to the surface modification of orthopedic implants, oral implants and other medical metal and alloy implants that need to be permanently integrated with bones.

Description

technical field [0001] The invention relates to medical metal surface treatment, in particular to a biocompatible metal and alloy surface multifunctional coating, a preparation method and an application. Background technique [0002] In recent years, with the development of medical technology, metal or alloy materials such as titanium and aluminum have been more and more widely used in the medical field, but all kinds of metal materials that have been developed have performance defects to varying degrees. These non-degradable metal materials are biologically inert materials, and the osseointegration performance between the surface and the insufficient part of the host is not good after implantation in the human body. For example, the elastic modulus of titanium is about 110GPa, which is much higher than the modulus of human bones (7-30GPa). The implantation of metal titanium prosthesis will cause poor osseointegration and easy loosening around the prosthesis due to stress sh...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/30A61L27/06A61L27/04A61L27/50A61L27/54A61L31/08A61L31/02A61L31/14A61L31/16C23C26/00
CPCA61L27/047A61L27/06A61L27/306A61L27/32A61L27/50A61L27/54A61L31/022A61L31/086A61L31/088A61L31/14A61L31/16A61L2300/102A61L2300/106A61L2300/404A61L2300/412A61L2300/602A61L2300/606A61L2400/18A61L2420/02A61L2420/06A61L2420/08C23C26/00
Inventor 叶招明王翊凯苟中入滕王锶源刘安章增杰叶宇霄杨贤燕
Owner ZHEJIANG UNIV
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