Piprazole antipsychotic drug key intermediate and electroreduction method thereof

Abstract

The invention discloses a benzo [b] thiophene-4-yl) piperazine derivative shown as a formula I or a salt thereof, an electroreduction method of the benzo [b] thiophene-4-yl) piperazine derivative andapplication of the benzo [b] thiophene-4-yl) piperazine derivative in preparation of antipsychotic drugs. n is selected from 2, 3 or 4; nitro is selected from 2-NO2, 3-NO2 and 4-NO2; and the salt is selected from hydrochloride, hydrobromide, sulfate, nitrate, phosphate, p-toluenesulfonate, benzene sulfonate, mesylate, trifluoromethanesulfonate or trifluoroacetate.

Description

technical field

[0001] The present invention relates to a new class of compound, its preparation method and its application in the field of medicine. Specifically, it is benzo[b]thiophen-4-yl)piperazine derivatives and their electroreduction method and their application in the preparation of Kang psychotropic drugs. Background technique

[0002] Hiroshi Yamashita et al. [CN102558140A, 2012.7.11] described 1-(benzo[b]thiophen-4-yl)-4-(4-(substituted phenoxy)butyl)piperazine and its preparation.

[0003]

[0004] Y=H, 4-F, 4-CN, 3-CN, 2-CN, 4-CO 2 H,3-CO 2 H,2-CO 2 H,3-CONH 2 , 3-CONHCH 3 , 4-CONHCH 3 , 3-CON(CH 3 ) 2 , 4-CON(CH 3 ) 2 , 4-CONHC 2 h 5 , 3-CONHC 2 h 5 , 2-CONHC 2 h 5 , 4-CONHCH 2 CF 3 , 3-CONHCH 2 CF 3 , 3-NHCO 2 CH 3 , 4-NHCO 2 CH 3 or 2-OCH 3 -4-COCH 3

[0005] Yang Feipu et al [Bioorganic & Medicinal Chemistry Letters, 2016,26(13):3141-3147] described 1-(benzo[b]thiophen-4-yl)-4-(4-(3-methoxy / methylaminocarbonyl Phenoxy)butyl)pi...

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